Nanomedicine: Nanotechnology, Biology and Medicine
Volume 1, Issue 1 , Pages 31-40, March 2005

In situ sensing and manipulation of molecules in biological samples using a nanorobotic system

  • Guangyong Li, MS

      Affiliations

    • College of Engineering, Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824
    • ,
  • Ning Xi, PhD

      Affiliations

    • College of Engineering, Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824
    • Corresponding Author InformationCorresponding author.
    • ,
  • Donna H. Wang, MD

      Affiliations

    • Department of Medicine, Michigan State University, East Lansing, Michigan

Received 5 October 2004; accepted 23 November 2004.

Abstract 

Background

Atomic force microscopy (AFM) is a powerful and widely used imaging technique that can visualize single molecules both in air and solution. Using the AFM tip as an end-effector, an atomic force microscope can be modified into a nanorobot that can manipulate objects in nanoscale.

Methods

By functionalizing the AFM tip with specific antibodies, the nanorobot is able to identify specific types of receptors on cells' membrane. It is similar to the fluorescent optical microscopy but with higher resolution. By locally updating the AFm image based on interaction force infromation and objects' model during nanomanipulation, real-time visual feedback is obtained through the augmented reality interface.

Results

The development of the AFM-based nanorobotic system will enable us to simultaneously conduct in situ imaging, sensing, and manipulation at nanometer scale (eg, protein and DNA levels).

Conclusions

This new technology opens a promising way to individually study the function of biological system in molecular level.

Key words: Single molecule recognition, AFM, Nanomaniplation, Augmented reality

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PII: S1549-9634(04)00006-1

doi:10.1016/j.nano.2004.11.005

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 1, Issue 1 , Pages 31-40, March 2005

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