Nanomedicine: Nanotechnology, Biology and Medicine
Volume 2, Issue 2 , Pages 113-120 , June 2006

An antisense oligonucleotide carrier based on amino silica nanoparticles for antisense inhibition of cancer cells

Received 15 February 2006 ,Accepted 7 April 2006.

References 

  1. Loke SL, Stein CA, Zhang XH, Mori K, Nakanishi M, Subasinghe C, et al. Characterization of oligonucleotide transport into living cells. Proc Natl Acad Sci U S A. 1989;86:3474–3478
  2. Yakubov LA, Deeva EA, Zarytova VF, Ivanova EM, Ryte VV, Vlassov ASVYL. Mechanism of oligonucleotide uptake by cells: involvement of specific receptors. Proc Natl Acad Sci U S A. 1989;86:6454–6458
  3. Galbraith WM, Hobson WC, Giclas PC, Schechter PJ, Agrawal S. Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey. Antisense Res Dev. 1994;4:201–206
  4. Dagle JM, Andracki ME, DeVine RJ, Walder JA. Physical properties of oligonucleotides containing phosphoramidate-modified internucleoside linkages. Nucleic Acids Res. 1991;19:1805–1810
  5. Hanvey JC, Peffer NJ, Bisi JE, Thomson SA, Cadilla R, Josey JA, et al. Antisense and antigene properties of peptide nucleic acids. Science. 1992;258:1481–1485
  6. Bennett CF. Antisense oligonucleotides: is the glass half full or half empty?. Biochem Pharmacol. 1998;55:9–19
  7. Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature. 1995;374:546–549
  8. Chavany C, Le Doan T, Couvreur P, Puisieux F, Helene C. Polyalkylcyanoacrylate nanoparticles as polymeric carriers for antisense oligonucleotides. Pharm Res. 1992;9:441–449
  9. Zobel HP, Kreuter J, Werner D, Noe CR, Kumel G, Zimmer A. Cationic polyhexylcyanoacrylate nanoparticles as carriers for antisense oligonucleotides. Antisense Nucleic Acid Drug Dev. 1997;7:483–493
  10. He X, Wang K, Tan W, Liu B, Lin X, He C, et al. Bioconjugated nanoparticles for DNA protection from cleavage. J Am Chem Soc. 2003;125:7168–7169
  11. He X, Wang K, Tan W, Liu B, Lin X, Huang S, et al. A novel gene carrier based on amino-modified silica nanoparticles. Chin Sci Bull. 2003;48:223–228
  12. Bertling WM, Gareis M, Paspaleeva V, Zimmer A, Kreuter J, Nurnberg E, et al. Use of liposomes, viral capsids, and nanoparticles as DNA carriers. Biotechnol Appl Biochem. 1991;13:390–405
  13. Luo D, Saltzman WM. Synthetic DNA delivery systems. Nat Biotechnol. 2000;18:33–37
  14. Anderson WF. Human gene therapy. Nature. 1998;392:25–30
  15. Chollet P, Favrot MC, Hurbin A, Coll JL. Side effects of a systemic injection of linear polyethylenimine-DNA complexes. J Gene Med. 2002;4:84–91
  16. Cherng JY, Wetering P, Talsma H, Crommelin DJA, Hennink WE. Effect of size and serum proteins on transfection efficiency of poly((2-dimethylamino)ethyl methycrylate)-plasmid nanoparticles. Pharm Res. 1996;13:1038–1042
  17. Deshpande D, Blezinger P, Pillai R, Duguid J, Freimark B, Rolland A. Target specific optimization of cationic lipid-based systems for pulmonary gene therapy. Pharm Res. 1998;15:1340–1347
  18. Reszka R, Zhu JH, Weber F, Walther W, Greferath R, Dyballa S. Liposome mediated transfer of marker and cytokine genes into rat and human glioblastoma cells in vitro and in vivo. J Liposome Res. 1995;5:149–167
  19. Kneuer C, Sameti M, Haltner EG, Schiestel T, Schirra H, Schmidt H, et al. Silica nanoparticles modified with aminosilanes as carriers for plasmid DNA. Int J Pharm. 2000;196:257–261
  20. Kneuer C, Sameti M, Bakowsky U, Schiestel T, Schirra H, Schmidt H, et al. A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro. Bioconjug Chem. 2000;11:926–932
  21. Zhu S, Lv H, Xiang J, Tang K, Zhang B, Zhou M, et al. A novel nonviral nanoparticle gene vector: Poly-l-lysine-silica nanoparticles. Chin Sci Bull. 2002;47:654–658
  22. Roy I, Ohulchanskyy TY, Bharali DJ, Pudavar HE, Mistretta RA, Kaur N, et al. Optical tracking of organically modified silica nanoparticles as DNA carriers: a nonviral, nanomedicine approach for gene delivery. Proc Natl Acad Sci U S A. 2005;102:279–284
  23. Bharali DJ, Klejbor I, Stachowiak EK, Dutta P, Roy I, Kaur N. Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain. Proc Natl Acad Sci U S A. 2005;102:11539–11544
  24. Li F, Ackermann EJ, Bennett CF, Rothermel AL, Plescia J, Tognin S, et al. Pleiotropic cell-division defects and apoptosis induced by interference with surviving function. Nature Cell Biol. 1999;1:461–466
  25. Mei Z. Anti-apoptosis protein and the regulation of apoptosis. Foreign Med Sci Genet. 1999;22:281–285
  26. Ambrosini G, Adida C, Sirugo G, Altier DC. Induction of apoptosis and inhibition of cell proliferation by surviving gene targeting. J Biol Chem. 1998;273:11177–11182
  27. Olie RA, Simoes WP, Baumann B, Leech SH, Fabbro D, Stahel RA, et al. A novel antisense oligonucleotide targeting survivin expression induced apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Res. 2000;60:2805–2809
  28. Twentyman PR, Luscombe M. A study of some variables in tetrazolium dye (MTT) based assay for cell growth and chemosensitivity. Br J Cancer. 1987;56:279–285
  29. Santra S, Zhang P, Wang K, Tapec R, Tan W. Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers. Anal Chem. 2001;73:4988–4993
  30. Chung LA. A fluorescamine assay for membrane protein and peptide samples with non-amino containing lipids. Anal Biochem. 1997;248:195–201

 This work was partially supported by the National Key Basic Research Program (2002CB513100-10), High Tech Research and Development (863) Programme (2003AA302250), the Key Technologies Research and development Programme (2003BA310A16), Key Project of Natural Science Foundation of China (20135010), National Science Foundation of China (20405005), and Key Project Foundation of the China Education Ministry (03181).

 No financial conflict of interest was reported by the authors of this paper.

PII: S1549-9634(06)00043-8

doi: 10.1016/j.nano.2006.04.003

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 2, Issue 2 , Pages 113-120 , June 2006