Nanomedicine: Nanotechnology, Biology and Medicine
Volume 2, Issue 2 , Pages 82-88 , June 2006

Influence of macrophage activation on their capacity to bind bacterial antigens studied with atomic force microscopy

  • Marta Targosz, MSc

      Affiliations

    • Institute of Physics, Jagiellonian University, Cracow, Poland
    • Corresponding Author InformationCorresponding author.
  • ,
  • Aleksander Labuda, BSc

      Affiliations

    • Physics Department, McGill University, Montreal, Quebec, Canada
  • ,
  • Pawel Czuba, PhD

      Affiliations

    • Institute of Physics, Jagiellonian University, Cracow, Poland
  • ,
  • Rafal Biedroń, MSc

      Affiliations

    • Department of Immunology, Jagiellonian University Medical College, Cracow, Poland
  • ,
  • Magdalena Strus, PhD

      Affiliations

    • Department of Microbiology, Jagiellonian University Medical College, Cracow, Poland
  • ,
  • Andrzej Gamian, PhD

      Affiliations

    • Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
  • ,
  • Janusz Marcinkiewicz, MD

      Affiliations

    • Department of Immunology, Jagiellonian University Medical College, Cracow, Poland
  • ,
  • Marek Szymoński, PhD

      Affiliations

    • Institute of Physics, Jagiellonian University, Cracow, Poland

Received 11 February 2006 ,Accepted 8 April 2006.

References 

  1. Kelly D, Conway S, Aminov R. Commensal gut bacteria:. mechanism. of.. immune modulation. Trends Immunol. 2005;26:326–333
  2. Gorgon S, Clarke S, Greaves D, Doyle A. Molecular immunobiology of macrophages: recent progress. Curr Opin Immunol. 1995;7:24–33
  3. Wolfert MA, Murray TF, Boons G-J, Moore JN. The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan. J Biol Chem. 2002;277:39179–39186
  4. Hessle CC, Andersson B, Wold AE. Gram-positive and Gram-negative bacteria elicit different patterns of pro-inflammantory cytokines in human monocytes. Cytokine. 2005;30:311–318
  5. Muroi M, Tanamoto K. The polysaccharide portion plays an indispensable role in Salmonella lipopolysaccharide-induced activation of NF-κB through human Toll-Like Receptor 4. Infect Immun. 2002;70:6043–6047
  6. Looijesteijn PL, Trapet L, de Vrries E, Abee T, Hugenholtz J. Physiological function of exopolysaccharides produced by Lactococcus lactis. Int J Food Microibiol. 2001;64:71–80
  7. Da Silva Correia J, Soldau K, Christen U, Tobias PS, Ullevitch RJ. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. J Biol Chem. 2001;276:21129–21135
  8. Lipinski T, Jones C, Lemerciner X, Korzeniowska-Kowal A, Strus M, Rybka J, et al. Structural analysis of the Lactobacillus rhamnosus strain KL37C exopolysaccharide. Carbohydr Res. 2003;338:605–609
  9. Mielnik G, Gamian A, Doroszkiewicz W. Bacterial activity of normal cord serum (NCM) against Gram-negative rods with sialic acid-containing lipopolysaccharides (LPS). FEMS Immunol Med Microbiol. 2001;31:169–173
  10. Florin EF, Moy TV, Gaub HE. Adhesion forces between individual ligand-receptor pairs. Science. 1994;264:415–417
  11. Ros R, Schwesinger F, Anselmetti D, et al. Antigen binding forces of individually addressed single-chain Fv antibody molecules. Proc Natl Acad Sci U S A. 1998;95:7402–7405
  12. Hinterdorfer P, Baumgartner W, Gruber HJ, et al. Detection and localization of individual antibody-antigen recognition events by atomic force microscopy. Proc Natl Acad Sci U S A. 1996;93:3477–3481
  13. Bougrand P. Ligand-receptor interactions. Rep Prog Phys. 1999;62:921–968
  14. Moy VT, Florin EL, Gaub HE. Intermolecular forces and energies between ligands and receptors. Science. 1994;266:257–259
  15. Wojcikiewicz EP, Zhang X, Moy VT. Force and compilance measurement on living cell using atomic force microscopy (AFM). Biol Proced Online. 2004;6:1–9
  16. Chen A, Moy VT. Cross-linking of cell surface receptors enhances cooperativity of molecular adhesion. Biophys J. 2000;78:2814–2820
  17. Dammer U, Popescu O, Wagner P, Anselmetti D, Guntherodt HJ, Misevic GN. Binding strength between cell adhesion proteoglycans measured by atomic force microscopy. Science. 1995;267:1173–1175
  18. Ratto TV, Langry KC, Rudol RE, Balhorn RL, Allen MJ, McElfresh MW. Force spectroscopy of the double-tethered Concanavalin-A mannose bound. Biophys J. 2004;86:2430–2437
  19. Evans E, Ritchie K. Strength of a weak bond connecting flexible polymer chains. Biophys J. 1999;76:2439–2447
  20. Gittes F, Schmidt CF. Thermal noise limitations on micromechanical experiments. Eur Biophys J. 1998;27:75–81

 This work was supported by grants 1 P03B 098 28 and 3 T11E 033 26 from the Committee for Scientific Research (MNII) of Poland.

PII: S1549-9634(06)00046-3

doi: 10.1016/j.nano.2006.04.006

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 2, Issue 2 , Pages 82-88 , June 2006