Nanomedicine: Nanotechnology, Biology and Medicine
Volume 2, Issue 4 , Pages 207-215 , December 2006

Nano hemostat solution: immediate hemostasis at the nanoscale

  • Rutledge G. Ellis-Behnke, PhD

      Affiliations

    • Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • State Key Laboratory for Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • Corresponding Author InformationCorresponding authors. R.G. Ellis-Behnke, Department of Brain and Cognitive Sciences, 46-6007, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; K.-F. So, Department of Anatomy, University of Hong Kong Faculty of Medicine, Hong Kong, SAR, China.
    • ,
  • Yu-Xiang Liang, PhD

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • State Key Laboratory for Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • ,
  • David K.C. Tay, PhD

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • State Key Laboratory for Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • ,
  • Phillis W.F. Kau, BSc

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • State Key Laboratory for Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • ,
  • Gerald E. Schneider, PhD

      Affiliations

    • Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    • ,
  • Shuguang Zhang, PhD

      Affiliations

    • Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    • ,
  • Wutian Wu, MD, PhD

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • State Key Laboratory for Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • ,
  • Kwok-Fai So, PhD

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • State Key Laboratory for Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    • Corresponding Author InformationCorresponding authors. R.G. Ellis-Behnke, Department of Brain and Cognitive Sciences, 46-6007, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; K.-F. So, Department of Anatomy, University of Hong Kong Faculty of Medicine, Hong Kong, SAR, China.

Received 22 August 2006 ,Accepted 22 August 2006.

References 

  1. Alam HB, Burris D, DaCorta JA, Rhee P. Hemorrhage control in the battlefield: role of new hemostatic agents. Mil Med. 2005;170:63–69
  2. Bergel S. Über Wirkungen des Fibrins. Dtsch Med Wochenschr. 1909;35:633
  3. Blocksom JM, Sugawa C, Tokioka S, Williams M. The Hemoclip: a novel approach to endoscopic therapy for esophageal perforation. Dig Dis Sci. 2004;49:1136–1138
  4. Dunser MW, et al. Does arginine vasopressin influence the coagulation system in advanced vasodilatory shock with severe multiorgan dysfunction syndrome?. Anesth Analg. 2004;99:201–206
  5. Grey E. Fibrin as a hemostatic in cerebral surgery. Surg Gynecol Obstet. 1915;21:452
  6. Hambleton J, Leung LL, Levi M. Coagulation: consultative hemostasis. In: American Society for Hematology Educational Program. 2002;p. 335–352
  7. Pallapies D. Vasoactive drugs with an effect on the prostaglandin system. Germ. Wien Klin Wochenschr. 1992;104:521–525
  8. Petersen B, et al. Tissue adhesives and fibrin glues. Gastrointest Endosc. 2004;60:327–333
  9. Quick AJ. Hemostasis in surgical procedures. Surg Gynecol Obstet. 1969;128:523–532
  10. Schonauer C, Tessitore E, Barbagallo G, Albanese V, Moraci A. The use of local agents: bone wax, gelatin, collagen, oxidized cellulose. Eur J Spine. 2004;13(Suppl 1):S89–S96
  11. Kaplan M, Bozkurt S, Kut MS, Kullu S, Demirtas MM. Histopathological effects of ethyl 2-cyanoacrylate tissue adhesive following surgical application: an experimental study. Eur J Cardiothorac Surg. 2004;25:167–172
  12. De Caterina R, et al. Bleeding time and bleeding: an analysis of the relationship of the bleeding time test with parameters of surgical bleeding. Blood. 1994;84:3363–3370
  13. Carr Jr ME. Monitoring of hemostasis in combat trauma patients. Mil Med. 2004;169:11-5, 4.
  14. Hoffman M. The cellular basis of traumatic bleeding. Mil Med. 2004; 169: 5-7, 4.
  15. Alam HB, Koustova E, Rhee P. Combat casualty care research: from bench to the battlefield. World J Surg. 2005;29(Suppl 1):S7–S11
  16. Konturek SJ, Pawlik W. Physiology and pharmacology of prostaglandins. Dig Dis Sci. 1986;31:6S–19S
  17. Greer IA. Therapeutic progress—review XXVIII. Platelet function and calcium channel blocking agents. J Clin Pharm Ther. 1987;12:213–222
  18. Kunstlinger F, Brunelle F, Chaumont P, Doyon D. Vascular occlusive agents. AJR Am J Roentgenol. 1981;136:151–156
  19. Sabel M, Stummer W. The use of local agents: Surgicel and Surgifoam. Eur J Spine. 2004;13(Suppl 1):S97–S101
  20. Bhanot S, Alex J. C. Current applications of platelet gels in facial plastic surgery. Facial Plast Surg. 2002;18:27–33
  21. Ellis-Behnke RG, et al. Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc Natl Acad Sci U S A. 2006;103:5054–5059
  22. Wu W. Expression of nitric-oxide synthase (NOS) in injured CNS neurons as shown by NADPH diaphorase histochemistry. Exp Neurol. 1993;120:153–159
  23. Yick LW, So KF, Cheung PT, Wu WT. Lithium chloride reinforces the regeneration-promoting effect of chondroitinase ABC on rubrospinal neurons after spinal cord injury. J Neurotrauma. 2004;21:932–943
  24. Kornecki E, Lenox RH, Hardwick DH, Bergdahl JA, Ehrlich YH. Interactions of the alkyl-ether-phospholipid, platelet activating factor (PAF) with platelets, neural cells, and the psychotropic drugs triazolobenzodiazepines. Adv Exp Med Biol. 1987;221:477–488
  25. Zhang S, Holmes T, Lockshin C, Rich A. Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. Proc Natl Acad Sci U S A. 1993;90:3334–3338
  26. Zhang S, et al. Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials. 1995;16:1385–1393
  27. Holmes TC, et al. Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proc Natl Acad Sci U S A. 2000;97:6728–6733
  28. Zhang S, Marini DM, Hwang W, Santoso S. Design of nanostructured biological materials through self-assembly of peptides and proteins. Curr Opin Chem Biol. 2002;6:865–871
  29. Zhang S. Fabrication of novel biomaterials through molecular self-assembly. Nat Biotechnol. 2003;21:1171–1178
  30. Caplan MR, Schwartzfarb EM, Zhang S, Kamm RD, Lauffenburger DA. Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence. Biomaterials. 2002;23:219–227
  31. Caplan MR, Moore PN, Zhang S, Kamm RD, Lauffenburger DA. Self-assembly of a β-sheet protein governed by relief of electrostatic repulsion relative to van der Waals attraction. Biomacromolecules. 2000;1:627–631
  32. Stassen JM, Arnout J, Deckmyn H. The hemostatic system. Curr Med Chem. 2004;11:2245–2260
  33. Zhang S, Zhao X, Spirio L. Self-assembling peptide nanofiber scaffolds. In:  Elisseeff PX,  Ma J editor. Scaffolding in tissue engineering. Boca, Raton, FL: Taylor & Francis/CRC Press; 2005;p. 217–238
  34. Lind SE. The bleeding time does not predict surgical bleeding. Blood. 1991;77:2547–2552
  35. Cylwik D, Mogielnicki A, Kramkowski K, Stokowski J, Buczko W. Antithrombotic effect of l-arginine in hypertensive rats. J Physiol Pharmacol. 2004;55:563–574
  36. Wang WT, Lin LN, Pan XR, Xu ZJ. Effects of l-arginine on the function of platelet aggregation during hepatic ischemia/reperfusion injury. (in Chinese) Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004;16:49–51
  37. Wang YY, Tang ZY, Dong M, Liu XY, Peng SQ. Inhibition of platelet aggregation by polyaspartoyl l-arginine and its mechanism. Acta Pharmacol Sin. 2004;25:469–473
  38. Finlay HM, McCullough L, Canham PB. Three-dimensional collagen organization of human brain arteries at different transmural pressures. J Vasc Res. 1995;32:301–312
  39. Sipkema P, van der Linden PJ, Westerhof N, Yin FC. Effect of cyclic axial stretch of rat arteries on endothelial cytoskeletal morphology and vascular reactivity. J Biomech. 2003;36:653–659
  40. Moore JE, et al. A device for subjecting vascular endothelial cells to both fluid shear stress and circumferential cyclic stretch. Ann Biomed Eng. 1994;22:416–422
  41. Ives CL, Eskin SG, McIntire LV. Mechanical effects on endothelial cell morphology: in vitro assessment. In Vitro Cell Dev Biol. 1986;22:500–507

 The authors declare a competing financial interest: S.Z. is a co-founder and board member of 3D Matrix, the provider of one of the materials used.

 This work was supported by grants from the Deshpande Center for Technological Innovation at the Massachusetts Institute of Technology and the Research Grant Council (RGC) of Hong Kong.

PII: S1549-9634(06)00108-0

doi: 10.1016/j.nano.2006.08.001

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 2, Issue 4 , Pages 207-215 , December 2006

Article Tools

* Image Usage & Resolution