Cerium doping and stoichiometry control for biomedical use of La0.7Sr0.3MnO3 nanoparticles: microwave absorption and cytotoxicity study

Kale, Sangeeta N.; Arora, Sumit; Bhayani, Kavita R.; Paknikar, Kishore M.; Jani, Mona; Wagh, Ulhas V.; Kulkarni, Shailaja D.; Ogale, Satish B.

doi:10.1016/j.nano.2006.10.001

« Previous Next »Nanomedicine: Nanotechnology, Biology and Medicine
Volume 2, Issue 4 , Pages 217-221, December 2006

Cerium doping and stoichiometry control for biomedical use of La_0.7Sr_0.3MnO₃ nanoparticles: microwave absorption and cytotoxicity study

Sangeeta N. Kale, PhD
- Nanobiotechnology Group, Agharkar Research Institute, Pune, India
- On leave from Fergusson College, Pune 411 004, India.
Sumit Arora, MSc
- Nanobiotechnology Group, Agharkar Research Institute, Pune, India
Kavita R. Bhayani, MSc
- Nanobiotechnology Group, Agharkar Research Institute, Pune, India
Kishore M. Paknikar, PhD
- Nanobiotechnology Group, Agharkar Research Institute, Pune, India
- Corresponding author. Nanobiotechnology Group, Agharkar Research Institute, G.G. Agarkar Road, Pune 411 004, India.
Mona Jani, MSc
- Computer Science Unit, Fergusson College, Pune, India
Ulhas V. Wagh, PhD
- Interactive Research School for Health Affairs, Pune, India
Shailaja D. Kulkarni, PhD
- Centre for Materials Characterization, National Chemical Laboratory, Pune, India
Satish B. Ogale, PhD
- Physical and Materials Chemistry Division, National Chemical Laboratory, Pune, India

Received 4 September 2006; accepted 14 October 2006.

Abstract

La_0.7Sr_0.3MnO₃ nanoparticles doped with cerium (La_0.7–xCe_xSr_0.3MnO₃ where 0 ≤ x ≤ 0.7) as well as the La_1–ySr_yMnO₃ nanoparticles with different values of y (La/Sr ratio) are evaluated for cytotoxicity and heating application. Considering hyperthermia as one of the possible application domains of such materials, the cytotoxicity studies were done on human skin carcinoma and human fibrosarcoma cell lines. All the samples showed the desired heating effect when subjected to high-frequency exposure at 2.45 GHz. Cytotoxicity studies revealed extremely low cytotoxicity in Ce-doped samples as well as in samples with a reduced La/Sr ratio. A maximum percentage cell viability on exposure to these nanoparticles was 95% and 85% for the two groups of samples, respectively, with a dose of 20 μg/mL for the x = 0.4 sample. The issues of dopant solubility and nonstoichiometry are discussed.