Biocompatible nanofiber scaffolds on metal for controlled release and cell colonization

Dong, Wenjun; Zhang, Tierui; McDonald, Michelle; Padilla, Carmen; Epstein, Joshua; Tian, Z. Ryan

doi:10.1016/j.nano.2006.10.005

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Volume 2, Issue 4 , Pages 248-252, December 2006

Biocompatible nanofiber scaffolds on metal for controlled release and cell colonization

Wenjun Dong, PhD
- Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas, USA
Tierui Zhang, PhD
- Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas, USA
Michelle McDonald, BSc
- Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas, USA
Carmen Padilla, BSc
- Department of Cell and Molecular Biology, University of Arkansas, Fayetteville, Arkansas, USA
Joshua Epstein, DSc
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Z. Ryan Tian, PhD
- Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas, USA
- Department of Cell and Molecular Biology, University of Arkansas, Fayetteville, Arkansas, USA
- Department of Microelectronics and Photonics, University of Arkansas, Fayetteville, Arkansas, USA
- Corresponding author. Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, USA.

Received 29 August 2006; accepted 18 October 2006.

Abstract

This paper reports for the first time a preparation of biocompatible titanate nanofiber scaffolds on the surface of titanium foil/mesh via a one-step hydrothermal reaction. The length and diameter of the nanofibers can be controlled by varying the fabrication parameters, such as reaction temperature, precursor concentration, and reaction time. The nanofibers can self-organize into macroporous (mostly 0.5−10 μm in diameter) scaffolds potentially useful for developing new bioscaffolds, photocatalysts, sensors, and drug delivery vehicles.

Key words: Biocompatible, Nanofiber scaffolds, Controlled release, Cell colonization