Nanomedicine: Nanotechnology, Biology and Medicine
Volume 3, Issue 2 , Pages 161-167, June 2007

Preparation and antibacterial activity evaluation of rifampicin-loaded poly lactide-co-glycolide nanoparticles

  • Farnaz Esmaeili, PharMD

      Affiliations

    • Novel Drug Delivery Systems Lab, Pharmaceutics Department, Faculty of Pharmacy, Medical Sciences, University of Tehran, Tehran, Iran
    • ,
  • Mahdi Hosseini-Nasr

      Affiliations

    • Novel Drug Delivery Systems Lab, Pharmaceutics Department, Faculty of Pharmacy, Medical Sciences, University of Tehran, Tehran, Iran
    • ,
  • Mazda Rad-Malekshahi

      Affiliations

    • Novel Drug Delivery Systems Lab, Pharmaceutics Department, Faculty of Pharmacy, Medical Sciences, University of Tehran, Tehran, Iran
    • ,
  • Nasrin Samadi, PhD

      Affiliations

    • Drug and Food Control Department, Faculty of Pharmacy, Medical Sciences, University of Tehran, Tehran, Iran
    • ,
  • Fatemeh Atyabi, PhD

      Affiliations

    • Novel Drug Delivery Systems Lab, Pharmaceutics Department, Faculty of Pharmacy, Medical Sciences, University of Tehran, Tehran, Iran
    • ,
  • Rassoul Dinarvand, PhD

      Affiliations

    • Novel Drug Delivery Systems Lab, Pharmaceutics Department, Faculty of Pharmacy, Medical Sciences, University of Tehran, Tehran, Iran
    • Medical Nanotechnology Research Centre, Medical Sciences, University of Tehran, Tehran, Iran
    • Corresponding Author InformationCorresponding author. Pharmaceutics Department, Medical Sciences, University of Tehran, Tehran, Iran.

Received 6 January 2007; accepted 2 March 2007. published online 10 May 2007.

Abstract 

Biodegradable polymers such as poly lactide-co-glycolides (PLGA) have been considered for the preparation of nanoparticles (NPs). In this study, rifampicin (RIF)-loaded PLGA NPs were fabricated by an emulsification/solvent diffusion method. The effect of several variables on the NPs' characteristics were evaluated, including the amount of RIF, amount of the poly vinyl alcohol as surfactant, and internal-phase volume and composition. The RIF encapsulation efficacy and the particle size distribution were optimized by varying these parameters. NPs were spherical with a relatively monodispersed size distribution. The effect of nanoencapsulation of RIF on the antibacterial activity of RIF against gram-positive and gram-negative bacteria was evaluated. It was shown that RIF NPs could considerably improve the RIF antibacterial efficacy.

Key words: Rifampicin, Nanoparticles, Antimicrobial delivery, Antibacterial activity, Poly lactide-co-glycolide

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 No conflict of interest was reported by the authors of this paper.

PII: S1549-9634(07)00049-4

doi:10.1016/j.nano.2007.03.003

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 3, Issue 2 , Pages 161-167, June 2007

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