Nanomedicine: Nanotechnology, Biology and Medicine
Volume 3, Issue 3 , Pages 239-243 , September 2007

Chemotherapeutic evaluation of alginate nanoparticle-encapsulated azole antifungal and antitubercular drugs against murine tuberculosis

  • Zahoor Ahmad, PhD

      Affiliations

    • Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    • ,
  • Sadhna Sharma, PhD

      Affiliations

    • Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    • ,
  • Gopal K. Khuller, PhD

      Affiliations

    • Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    • Corresponding Author InformationCorresponding author. Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Sector-12, Chandrigarh 160012, India.

Received 3 March 2007 ,Accepted 24 May 2007.

References 

  1. Guardiola-Diaz HM, Foster LA, Mushrush D, Vaz AND. Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis. Biochem Pharmacol. 2001;61:1463–1470
  2. Zahoor A, Sharma S, Khuller GK. In vitro and ex vivo antimycobacterial potential of azole drugs against M. tuberculosis H37RV. FEMS Microbiol Lett. 2005;251:19–22
  3. Zahoor A, Pandey R, Sharma S, Khuller GK. The potential of azole antifungals against latent/ persistent tuberculosis. FEMS Microbiol Lett. 2006;258:200–203
  4. Zahoor A, Pandey R, Sharma S, Khuller GK. Azole antifungals as novel chemotherapeutic agents against murine tuberculosis. FEMS Microbiol Lett. 2006;261:181–186
  5. Hostetler JS, Hanson LH, Stevens DA. Effect of cyclodextrin on the pharmacology of antifungal oral azoles. Antimicrob Agents Chemother. 1992;36:477–480
  6. Pandey R, Zahoor A, Sharma S, Khuller GK. Nano-encapsulation of azole antifungals: potential applications to improve oral drug bioavailability. Int J Pharm. 2005;301:268–276
  7. Rajaonarivony M, Vauthier C, Couarraze G, Puisieux F, Couvreur P. Development of a new drug carrier made from alginate. J Pharm Sci. 1993;82:912–917
  8. Zahoor A, Pandey R, Sharma S, Khuller GK. Evaluation of antitubercular drug loaded alginate nanoparticles against experimental tuberculosis. J Nanosci. 2006;1:81–85
  9. Pandey R, Sharma S, Khuller GK. Chemotherapeutic efficacy of nanoparticle encapsulated antitubercular drugs. Drug Deliv. 2006;13:287–294
  10. Zahoor A, Pandey R, Sharma S, Khuller GK. Pharmacokinetic and pharmacodynamic behaviour of antitubercular drugs encapsulated in alginate nanoparticles at two doses. Int J Antimicrob Agents. 2006;27:420–427
  11. Rattan A. Development of new drugs for tuberculosis. In:  Gupta S,  Sood OP editor. Tuberculosis: Proceedings of the 7th Round Table Conference, Ranbaxy Research Foundations, New Delhi. 2000;p. 113–122
  12. Pandey R, Zahoor A, Sharma S, Khuller GK. Nanoparticle encapsulated antitubercular drugs as a potential oral drug delivery system against murine tuberculosis. Tuberculosis. 2003;83:373–378
  13. Leys D, Mowat CG, McLean KJ, Richmond A, Chapman SK, Walkinshaw MD, et al. Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 Å reveals novel features of cytochrome P450. J Biol Chem. 2003;278:5141–5147
  14. Cui JH, Goh JS, Park SY, Kim PH, Lee BJ. Preparation and physical characterization of alginate microparticles using air atomization method. Drug Dev Ind Pharm. 2001;27:309–319
  15. Joseph I, Venkataram S. Indomethacin sustained release from alginate-gelatin or pectin-gelatin coacervates. Int J Pharm. 1995;126:161–168
  16. Gonzalez-Rodriguez ML, Holgado MA, Sanchez-Lafuente C, Rabasco AM, Fini A. Alginate-chitosan particulate systems for sodium diclofenac release. Int J Pharm. 2002;232:225–234
  17. Takka S, Acarturk F. Calcium alginate microparticles for oral administration: I: effect of sodium alginate type on drug release and drug entrapment efficiency. J Microencapsulation. 1999;16:275–290
  18. Chickering DE, Jacob JS, Desai TA, Harrison M, Harris WP, Morrell CN, et al. Bioadhesive microspheres: III. An in vivo transit and bioavailability study of drug loaded alginate and poly (fumaric-co-sebacic anhydride) microspheres. J Control Release. 1997;48:35–46
  19. Lannuccelli V, Coppi G, Cameroni R. Biodegradable intraoperative system for bone infection treatment. I. The drug/polymer interaction. Int J Pharm. 1996;143:195–201
  20. Whitehead L, Collett JH, Fell JT. Amoxicillin release from a floating dosage form based on alginates. Int J Pharm. 2000;210:45–49

 No conflict of interest was reported by the authors of this paper.

PII: S1549-9634(07)00087-1

doi: 10.1016/j.nano.2007.05.001

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 3, Issue 3 , Pages 239-243 , September 2007

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