Nanomedicine: Nanotechnology, Biology and Medicine
Volume 3, Issue 4 , Pages 281-296 , December 2007

Significant effect of size on the in vivo biodistribution of gold composite nanodevices in mouse tumor models

  • Lajos Balogh, PhD

      Affiliations

    • The NanoBiotechnology Center at Roswell Park Cancer Institute (NBC at RPCI), Department of Radiation Medicine, and joint appointment in the Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA
    • Equally contributed to the research.
    • ,
  • Shraddha S. Nigavekar, PhD

      Affiliations

    • Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    • ,
  • Bindu M. Nair, PhD

      Affiliations

    • The NanoBiotechnology Center at Roswell Park Cancer Institute (NBC at RPCI), Department of Radiation Medicine, and joint appointment in the Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA
    • ,
  • Wojciech Lesniak, PhD

      Affiliations

    • The NanoBiotechnology Center at Roswell Park Cancer Institute (NBC at RPCI), Department of Radiation Medicine, and joint appointment in the Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA
    • ,
  • Chunxin Zhang, PhD

      Affiliations

    • Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, Michigan, USA
    • ,
  • Lok Yun Sung, BS

      Affiliations

    • Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    • ,
  • Muhammed S.T. Kariapper, PhD

      Affiliations

    • The NanoBiotechnology Center at Roswell Park Cancer Institute (NBC at RPCI), Department of Radiation Medicine, and joint appointment in the Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA
    • ,
  • Areej El-Jawahri, BS

      Affiliations

    • Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    • ,
  • Mikel Llanes, BS

      Affiliations

    • Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    • ,
  • Brian Bolton, MD

      Affiliations

    • Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, Michigan, USA
    • ,
  • Fatema Mamou, BS

      Affiliations

    • Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    • ,
  • Wei Tan, MA

      Affiliations

    • Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, New York, USA
    • ,
  • Alan Hutson, PhD

      Affiliations

    • Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, New York, USA
    • ,
  • Leah Minc, PhD

      Affiliations

    • Radiation Center, Oregon State University, Corvallis, Oregon, USA
    • ,
  • Mohamed K. Khan, MD, PhD

      Affiliations

    • The NanoBiotechnology Center at Roswell Park Cancer Institute (NBC at RPCI), Department of Radiation Medicine, and joint appointment in the Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA
    • Corresponding Author InformationCorresponding author. Roswell Park Cancer Institute, Radiation Medicine, Buffalo, NY 14263, USA.
    • Equally contributed to the research.

Received 3 May 2007 ,Accepted 17 September 2007.

References 

  1. Balogh L, Swanson DR, Spindler R, Tomalia DA. Formation and characterization of dendrimer-based water soluble inorganic nanocomposites. Proceedings of the Division of Polymeric Materials Science and Engineering, American Chemical Society. 1997;77:118–119
  2. Balogh L, Tomalia DA. Dendrimer-templated nanocomposites I. Synthesis of zero-valent copper nanoclusters. J Am Chem Soc. 1998;120:7355–7356
  3. Tomalia DA, Balogh L. Nanocomposites of dendritic polymers. United States patent US 6664315 B2. Dec 16 2003.
  4. Tomalia DA, Balogh L. Nanocomposites of dendritic polymers. United States patent US 6995234. Feb 7 2006.
  5. Zhao M, Sun L, Crooks RM. Preparation of Cu nanoclusters within dendrimer templates. J Am Chem Soc. 1998;120:4877–4878
  6. Khan MK, Nigavekar SS, Minc LD, Kariapper MST, Nair BM, Lesniak WG. In vivo biodistribution of dendrimers and dendrimer nanocomposites—implications for cancer imaging and therapy. Technol Cancer Res Treat. 2005;4:603–613
  7. Balogh L, Bielinska A, Eichman JD, Valluzi R, Lee I, Baker JR, et al. Dendrimer nanocomposites in medicine. Chim Oggi (Chemistry Today). 2002;20:35–40
  8. Bielinska A, Kukowska-Latallo JF, Johnson J, Tomalia DA, Baker JR. Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers. Nucleic Acids Res. 1996;24:2176–2182
  9. Delong R, Stephenson K, Loftus T, Fisher M, Alahari S, Nolting A, et al. Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery. J Pharm Sci. 1997;86:762–764
  10. Kukowska-Latallo JF, Bielinska AU, Johnson J, Spindler R, Tomalia DA, Baker JR. Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers. Proc Natl Acad Sci U S A. 1996;93:4897–4902
  11. Malik N, Evagorou EG, Duncan R. Dendrimer-platinate: a novel approach to cancer chemotherapy. Anticancer Drugs. 1999;10:767–776
  12. Malik N, Wiwattanapatapee R, Klopsch R, Lorenz K, Frey H, Weener JW, et al. Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo. J Control Release. 2000;65:133–148
  13. Roberts JC, Bhalgat MK, Zera RT. Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst dendrimers. J Biomed Mater Res. 1996;30:53–65
  14. Wiener EC, Konda S, Shadron A, Brechbiel M, Gansow O. Targeting dendrimer-chelates to tumors and tumor cells expressing the high-affinity folate receptor. Invest Radiol. 1997;32:748–754
  15. Balogh L, Valuzzi R, Laverdure KS, Gido SP, Hagnauer GL, Tomalia DA. Formation of silver and gold dendrimer nanocomposites. J Nanopart Res. 1999;1:353–368
  16. Bielinska A, Eichman JD, Lee I, Baker JR, Balogh L. Imaging {Au0-PAMAM} gold-dendrimer nanocomposites in cells. J Nanopart Res. 2002;4:395–403
  17. Tomalia DA, Baker H, Dewald JR, et al. Polym J (Tokyo). 1985;17:117–132
  18. Kukowska-Latallo JF, Candido KA, Cao Z, et al. Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. Cancer Res. 2005;65:5317–5324
  19. Nigavekar SS, Sung LY, Llanes M, El-Jawahri A, Lawrence TS, Becker CW, et al. 3H dendrimer nanoparticle organ/tumor distribution. Pharm Res. 2004;21:476–483
  20. Esumi K, Suzuki A, Aihara N, Usui K, Torigoe K. Preparation of gold colloids with UV irradiation using dendrimers as stabilizer. Langmuir. 1998;14:3157–3159
  21. Garcia ME, Baker LA, Crooks RM. Preparation and characterization of dendrimer-gold colloid nanocomposites. Anal Chem. 1999;71:256–258
  22. Ottaviani MF, Valluzzi R, Balogh L. Internal structure of silver-poly(amidoamine) dendrimer complexes and nanocomposites. Macromolecules. 2002;35:5105–5115
  23. Esumi K. Dendrimers for nanoparticle synthesis and dispersion stabilization. Top Curr Chem. 2003;227:31–52
  24. Martin CR. Nanomaterials: a membrane-based synthetic approach. Science. 1994;266:1961–1966
  25. Lesniak W, Bielinska AU, Sun K, et al. Silver/dendrimer nanocomposites as biomarkers: fabrication, characterization, in vitro toxicity, and intracellular detection. Nano Lett. 2005;5:2123–2130
  26. Root SW, Andrews GA, Knieseley RM, Tyor MP. The distribution and radiation effects of intravenously administered colloidal Au 198 in man. Cancer. 1954;7:856–866
  27. Rubin P, Levitt SH. The response of disseminated reticulum cell sarcoma to the intravenous injection of colloidal radioactive gold. J Nucl Med. 1964;5:581–594
  28. Balogh LP, Khan MK. Dendrimer nanocomposites for cancer therapy. In:  Amiji MM editors. Nanotechnology for cancer therapy. Boca Raton (Fla): CRC Press–Taylor & Francis Group; 2007;p. 551–592
  29. Holm HH. The history of interstitial brachytherapy of prostatic cancer. Semin Surg Oncol. 1997;13:431–437
  30. Uppuluri S, Swanson DR, Piehler LT, Li J, Hagnauer GL, Tomalia DA. Core-shell tecto(dendrimers): I. Synthesis and characterization of saturated shell models. Adv Mater. 2000;12:796–800
  31. Balogh LP, Valluzzi GL, Hagnauer GL, Laverdure KS, Gido SP, Tomalia DA. Formation of silver and gold dendrimer nanocomposites. J Nanopart Res. 1999;1:353–368
  32. Balogh LP, Nigavekar SS, Cook AC, Minc L, Khan MK. Development of dendrimer-gold radioactive nanocomposites to treat cancer microvasculature. Pharmachem. 2003;2:94–99
  33. Burda C, Chen X, Narayanan R, El-Sayed MA. Chemistry and properties of nanocrystals of different shapes. Chem Rev. 2005;105:1025–1102
  34. Balogh L, Ganser TR, Shi X. Characterization of dendrimer-gold nanocomposite materials. In: Paper presented at Materials Research Society Symposium Proceedings, 2005, Warrendale, PA. 2005;
  35. Zheng J, Zhang C, Dickson RM. Highly flourescent, water-soluble size-tunable gold quantum dots. Phys Rev Lett 2004;93:077402-1–4.
  36. Yonezawa T, Matsune H, Kunitake T. Layered nanocomposite of close-packed gold nanoparticles and TiO2 gel layers. Chem Mater. 1999;11:33–35
  37. Doremus RH, Rao P. Optical properties of nanosized gold particles. J Mat Res. 1996;11:2834–2840
  38. He JA, Valluzzi R, Yang R, et al. Electrostatic multilayer deposition of a gold-dendrimer nanocomposite. Chem Mater. 1999;11:3268–3274
  39. El-Sayed M, Kiani MF, Naimark MD, Hikal AH, Ghandehari H. Extravasation of poly(amidoamine) (PAMAM) dendrimers across microvascular network endothelium. Pharm Res. 2001;18:23–28
  40. Shi X, Majoros IJ, Baker JR. Capillary electrophoresis of poly(amidoamine) dendrimers: from simple derivatives to complex multifunctional medical nanodevices. Mol Pharmacol. 2005;2:278–294

 No conflict of interest was reported by the authors of this article.

PII: S1549-9634(07)00120-7

doi: 10.1016/j.nano.2007.09.001

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 3, Issue 4 , Pages 281-296 , December 2007

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