Nanomedicine: Nanotechnology, Biology and Medicine
Volume 3, Issue 4 , Pages 246-257 , December 2007

Development and characterization of hyaluronic acid–anchored PLGA nanoparticulate carriers of doxorubicin

  • Awesh Kumar Yadav, MPharm

      Affiliations

    • Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, India
    • ,
  • Pradeep Mishra, PhD

      Affiliations

    • Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, India
    • ,
  • Anil K. Mishra, PhD

      Affiliations

    • Institute of Nuclear Medicine and Allied Science, Timarpur, New Delhi, India
    • ,
  • Pushpa Mishra, PhD

      Affiliations

    • Institute of Nuclear Medicine and Allied Science, Timarpur, New Delhi, India
    • ,
  • Sanyog Jain, PhD

      Affiliations

    • Institute of Nuclear Medicine and Allied Science, Timarpur, New Delhi, India
    • ,
  • Govind Prasad Agrawal, PhD

      Affiliations

    • Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, India
    • Corresponding Author InformationCorresponding author. Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar (M.P.) 470003, India.

Received 15 May 2007 ,Accepted 20 September 2007.

References 

  1. Zhang JY. Apoptosis-based anticancer drugs. Nat Rev Drug Discovery. 2002;1:101–102
  2. Kim GJ, Nie S. Targeted cancer nanotherapy. Nanotoday. 2005;28–33
  3. Allemann E, Gurny R, Doelker E. Drug-loaded nanoparticles preparation method and drug targeting tissues. Eur J Pharm Biopharm. 1993;39:173–191
  4. Cavallaro G, Mariano L, Salmaso S, Caliceti P, Gaetano G. Folate mediated targeting of polymeric conjugates of gemcitabine. Int J Pharm. 2006;307:258–269
  5. Gref R, Luck M, Quellec P, Marchand M, Dellacherie E, Harnisch S, et al. ‘Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surfaces B: Biointerfaces. 2000;18:301–313
  6. Shuai X, Ai H, Nasongkla N, Kim S, Gao J. Micellar carriers based on block copolymers of poly (ε-caprolactone) and poly (ethylene glycol) for doxorubicin delivery. J Control Release. 2004;98:415–426
  7. Kim SY, Lee YM. Taxol-loaded block copolymer nanospheres composed of methoxy poly (ethylene glycol) and poly (ε-caprolactone) as novel anticancer drug carriers. Biomaterials. 2001;22:1697–1704
  8. Gref R, Couvreur P, Barratt G, Mysiakine E. Surface-engineered nanoparticles for multiple ligand coupling. Biomaterials. 2003;24:4529–4537
  9. Park EK, Lee SB, Lee YM. Preparation and characterization of methoxy poly (ethylene glycol)/poly (ε-caprolactone) amphiphilic block copolymeric nanospheres for tumor-specific folate-mediated targeting of anticancer drugs. Biomaterials. 2005;26:1053–1061
  10. Yun YH, Goetz DJ, Yellen P, Chen W. Hyaluronan microspheres for sustained gene delivery and site-specific targeting. Biomaterials. 2004;25:147–157
  11. Asplund T, Heldin P. Hyaluronan receptors are expressed on human malignant mesothelioma cells but not on normal mesothelial cells. Cancer Res. 1994;54:4516–4523
  12. Naor D, Nedvetzki S, Golan I, Melnik L, Faitelson Y. CD44 in cancer. Crit Rev Clin Lab Sci. 2002;39:527–579
  13. Wang C, Thor AD, Moore DH, Zhao Y, Kerschmann R, Stern R, et al. The overexpression of RHAMM, a hyaluronan-binding protein that regulates ras signalling, correlates with over-expression of mitogen-activated protein kinase and is a significant parameter in breast cancer progression. Clin Cancer Res. 1998;4:567–576
  14. Günthert U. CD44: a multitude of isoforms with diverse functions. Curr Topics Microbiol Immunol. 1993;184:47–63
  15. Culty M, Nguyen HA, Underhillm CB. The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan. J Cell Biol. 1992;116:1055–1062
  16. Coradini D, Pellizzaro C, Miglierini G, Daidone MG, Perbellini A. Hyaluronic acid as drug delivery for sodium butyrate: improvement of the anti-proliferative activity on a breast-cancer cell line. Int J Cancer. 1999;81:411–416
  17. Luo Y, Prestwich GD. Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate. Bioconjug Chem. 1999;10:755–763
  18. Zalipsky S, Gilon C, Zilkha A. Attachment of drugs to polyethylene glycols. Eur J. Polym. 1983;19:1177–1183
  19. Beletsi A, Panagi Z, Avgoustakis K. Biodistribution properties of nanoparticles based on mixtures of PLGA with PLGA-PEG diblock copolymers. Int J Pharm. 2005;298:233–241
  20. Jeong YI, Cheon JB, Kim SH, Nah JW, Lee YM, Sung YK, et al. Clonazepam release from core-shell type nanoparticles in vitro. J Control Release. 1998;51:169–178
  21. Dong Y, Feng SS. Methoxy poly (ethylene glycol)-poly (lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs. Biomaterials. 2004;25:2843–2849
  22. Paul M, Laatiris A, Fessi H, Dufeu B, Durand B, Deniau M, et al. Pentamidine-loaded poly (d,l-lactide) nanoparticles: adsorption and drug release. Drug Dev Res. 1998;43:98–104
  23. Chorny M, Fishbein I, Danenberg HD, Golomb G. Lipophilic drug loaded nanospheres by nanoprecipitation: effect of formulation variables on size, drug recovery and release kinetics. J Control Release. 2002;83:389–400
  24. Cho H, Chung D, Jeongho A. Poly (d,l-lactide-ran-ε-caprolactone)-poly(ethylene glycol)-poly(d,l lactide-ran-ε-caprolactone) as parenteral drug delivery systems. Biomaterials. 2004;25:3733–3742
  25. Luo Y, Kirker KR, Prestwich GD. Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery. J Control Release. 2000;69:169–184
  26. Ryu JG, Jeong YI, Kim YH, Kim IS, Kim DH, Kim SH. Preparation of core-shell type nanoparticles of poly(ε-caprolactone) /poly(ethylene glycol)/poly(ε-caprolactone) triblock copolymers. Bull Korean Chem Soc. 2001;22:467–475
  27. Park K, Lee GY, Kim YS, Yu M, Park RW, Kim IS, et al. Heparin–deoxycholic acid chemical conjugate as an anticancer drug carrier and its antitumor activity. J Control Release. 2006;114:300–306
  28. Shenoy D, Little S, Langer R, Amiji M. Poly (ethylene oxide)-modified poly (β-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: Part 2. In vivo distribution and tumor localization studies. Pharm Res. 2005;22:2101–2114
  29. Zeng C, Toole BP, Kinney SD, Kuo J, Stamenkovic I. Inhibition of tumor growth in vivo by hyaluronan oligomers. Int J Cancer. 1998;77:396–401
  30. Lesley J, Hascall VC, Tammi M, Hyman R. Hyaluronan binding by cell surface CD44. J Biol Chem. 2000;275:267–269
  31. Mo Y, Lim LY. Paclitaxel-loaded PLGA nanoparticles: potentiation of anticancer activity by surface conjugation with wheat germ agglutinin. J Control Release. 2005;108:244–262
  32. Anghileri LJ. In vivo synthesis of acid mucopolysaccharides by Ehrlich ascites tumor cells. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976;88:17–24

PII: S1549-9634(07)00124-4

doi: 10.1016/j.nano.2007.09.004

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 3, Issue 4 , Pages 246-257 , December 2007

Article Tools

* Image Usage & Resolution