Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 1 , Pages 79-87 , March 2008

Nanocryosurgery and its mechanisms for enhancing freezing efficiency of tumor tissues

  • Jing-Fu Yan, PhD (C)

      Affiliations

    • Cryogenics Laboratory, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China
    • ,
  • Jing Liu, PhD, BS, BE

      Affiliations

    • Cryogenics Laboratory, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China
    • Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China
    • Corresponding Author InformationCorresponding author: Cryogenics Laboratory, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China.

Received 11 March 2007 ,Accepted 13 November 2007.

References 

  1. Rubinsky B. Cryosurgery: advances in the application of low temperatures to medicine. Int J Refrig. 1991;14:190–199
  2. Gage AA. Cryosurgery in the treatment of cancer. Surg Gynecol Obstet. 1992;174:73–92
  3. Rubinsky B. Cryosurgery. Annu Rev Biomed Eng. 2000;2:157–187
  4. Izawa JI, Madsen LT, Scott SM, Tran JP, McGuire EJ, von Eschenbach AC, et al. Salvage cryotherapy for recurrent prostate cancer after radiotherapy: variables affecting patient outcome. J Clin Oncol. 2002;20:2664–2671
  5. Seifert JK, Springer A, Baier P, Junginger T. Liver resection or cryotherapy for colorectal liver metastases: a prospective case control study. Int J Colorectal Dis. 2005;20:507–520
  6. Bourne MH, Piepkorn MW, Clayton F, Leonard LG. Analysis of microvascular changes in frostbite injury. J Surg Res. 1986;40:26–35
  7. Jordan A, Wust P, Scholz R, Tesche B, Fahling H, Mitrovics T, et al. Cellular uptake of magnetic fluid particles and their effects on human adenocarcinoma cells exposed to AC magnetic fields in vitro. Int J Hyperthermia. 1996;12:705–722
  8. Johannsen M, Gneveckow U, Eckelt L, Feussner A, Waldofner N, Scholz R, et al. Clinical hyperthermia of prostate cancer using magnetic nanoparticles: presentation of a new interstitial technique. Int J Hyperthermia. 2005;21:637–647
  9. Johannsen M, Thiesen B, Gneveckow U, Taymoorian K, Waldofner N, Scholz R, et al. Thermotherapy using magnetic nanoparticles combined with external radiation in an orthotopic rat model of prostate cancer. Prostate. 2006;66:97–104
  10. Lv YG, Deng ZS, Liu J. Study on the induced heating effects of embedded micro/nano particles on human body subject to external medical electromagnetic field. IEEE Trans Nanobioscience. 2005;4:284–294
  11. Zhao DL, Zhang HL, Zeng XW, Xia QS, Tang JT. Inductive heat property of Fe3O4/polymer composite nanoparticles in an AC magnetic field for localized hyperthermia. Biomed Mater. 2006;1:198–201
  12. Andreas J, Regina S, Klaus MH, Manfred J, Peter M, Jacek N, et al. Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia. J Magn Magn Mater. 2001;225:118–126
  13. Kong G, Braun RD, Dewhrist MW. Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size. Cancer Res. 2000;60:4440–4445
  14. Brannon PL, Blanchette JO. Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev. 2004;56:1649–1659
  15. Visaria RK, Griffin RJ, Williams BW, Ebbini ES, Paciotti GF, Song CW, et al. Enhancement of tumor thermal therapy using gold nanoparticle–assisted tumor necrosis factor-α delivery. Mol Cancer Ther. 2006;5:1014–1020
  16. Xu J, Yu BM, Zou MQ, Xu P. A new model for heat conduction of nanofluids based on fractal distributions of nanoparticles. J Phys D Appl Phys. 2006;39:4486–4490
  17. Zhang X, Gu H, Fujii M. Experimental study on the effective thermal conductivity and thermal diffusivity of nanofluids. Int J Thermophys. 2006;27:569–580
  18. Yan JF, Liu J, Zhou YX. Infrared image to evaluate the selective (directional) freezing due to localized injection of thermally important solutions. In: 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS). Shanghai, China. 2005;
  19. Mazur P. The role of intracellular freezing in the death of cells cooled at supraoptimal rates. Cryobiology. 1977;14:251–272
  20. Toner M. Nucleation of ice crystals inside biological cells.. In:  Steponkus P editors. Advances in low-temperature biology. London: JAI Press; 1993;p. 1–51
  21. Yu TH, Liu J, Zhou YX. Selective freezing of target biological tissues after injection of solutions with specific thermal properties. Cryobiology. 2005;50:174–182
  22. Gage AA, Baust JG. Mechanisms of tissue injury in cryosurgery. Cryobiology. 1998;37:171–186
  23. Dreher KL. Health and environmental impact of nanotechnology: toxicological assessment of manufactured nanoparticles. Toxicol Sci. 2004;77:3–5
  24. Nel A, Xia T, Mädler L, Li N. Toxic potential of materials at the nanolevel. Science. 2006;311:622–627
  25. Jenkins J, Pant K, Hood J, Sundaram S. Multi-scale, mechano-biological model of nanoparticle toxicity. Nanotechnol. 2006;1:599–602
  26. Wickline SA, Lanza GM. Nanotechnology for molecular imaging and targeted therapy. Circulation. 2003;107:1092–1095
  27. Amy O, Farah T, Kenneth S, Alexander W, Stephen B. Magnetomotive contrast for in vivo optical coherence tomography. Opt Express. 2005;13:6597–6614
  28. http://mae.uta.edu/~bhan/research.html
  29. Deng ZS, Liu J. Numerical simulation on 3-D freezing and heating problems for the combined cryosurgery and hyperthermia therapy. Numer Heat Transf A Appl. 2004;46:587–611
  30. Rabin Y, Shitzer A. Numerical solution of the multidimensional freezing problem during cryosurgery. ASME J Biomech Eng. 1998;120:32–37
  31. Chato JC. Selected thermophysical properties of biological materials. In:  Shitzer A,  Eberhart EC editor. Heat transfer in medicine and biology. New York: Plenum Press; 1985;p. 413–418
  32. Ma QF. In: Practical thermal properties handbook. Beijing: Chinese Agriculture and Mechanic Press; 1986;p. 144–176
  33. Toner M, Cravalho EG. Thermodynamics and kinetics of intracellular ice formation during freezing of biological cells. J Appl Phys. 1990;67:1582–1594
  34. Turnbull D. Under what conditions can a glass be formed. Contemp Phys. 1969;10:473–488
  35. Taylor MJ. Physico-chemical principles in low temperature biology. In:  Grout BWW,  Morris GJ editor. The effect of low temperature on biological systems. Chicago: Edward Arnold; 1987;p. 3–71

 No conflict of interest was reported by the authors of this paper.

 This research is partially supported by the National Natural Science Foundation of China under Grants 50575219 and 50325622.

PII: S1549-9634(07)00247-X

doi: 10.1016/j.nano.2007.11.002

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 1 , Pages 79-87 , March 2008

Article Tools

* Image Usage & Resolution