Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 1 , Pages 41-48 , March 2008

Mannosylated gelatin nanoparticles bearing an anti-HIV drug didanosine for site-specific delivery

Received 20 June 2007 ,Accepted 16 November 2007.

References 

  1. Takakura Y, Hashida M. Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution. Pharm Res. 1996;13:820–831
  2. Auger MJ, Ross JA. The biology of the macrophage in the natural immune system: the macrophage. In: Lewis CE, Mcgee HOD, editors. Oxford: Oxford University Press; 1992. pp. 1-7.
  3. Levy JA. Pathogenesis of human immunodeficiency virus infection. Microbiol Rev. 1993;57:183–289
  4. Weiss RA. How does HIV cause AIDS. Science. 1993;260:1273–1279
  5. Largent BL, Walton KM, Hoppe CA, Lee YC, Schnaar RL. Carbohydrate-specific adhesion of alveolar macrophages to mannose derivatized surfaces. J Biol Chem. 1984;259:1764–1769
  6. Haltiwanger RS, Hill RL. The ligand binding specificity and tissue localization of a rat alveolar macrophage lectin. J Biol Chem. 1986;261:15696–15702
  7. Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and diagnosis. Adv Drug Del Rev. 2002;54:631–651
  8. Sakuma H, Ohshima TK. Binding constants of metal cations to and Hamaker constant for poly(N,N-lysine diylterephthaloyl) microcapsules. J Colloid Interface Sci. 1990;135:455–460
  9. Hans ML, Lowman AM. Biodegradable nanoparticles for drug delivery and targeting. Curr Opin Solid State Mater Sci. 2002;6:319–327
  10. Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Del Rev. 2003;55:329–347
  11. Nakada Y, Fattal E, Foulquier M, Couvreur P. Pharmacokinetics and biodistribution of oligonucleotide adsorbed onto poly(isobutylcyanoacrylate) nanoparticles after intravenous administration in mice. Pharm Res. 1996;13:37–43
  12. Sakuma S, Sudo R, Suzuki N, Kikuchi H, Akashi M, Hayashi M. Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract. Int J Pharm. 1999;177:161–172
  13. Ammoury N, Fessi H, Devissaguet JP, Dubrasquet M, Benita S. Jejunal absorption, pharmacological activity, and pharmacokinetic evaluation of indomethacin-loaded poly(d,l-lactide and poly(isobutyl-cyanoacrylate) nanocapsules in rats. Pharm Res. 1991;8:101–105
  14. Grangier JL, Puygrenier M, Gautier JC, Couvrear P. Nanoparticles as carriers for growth hormone releasing factor. J Control Rel. 1991;15:3–13
  15. Hamdi G, Ponchel G, Duchene D. An original method for studying in vitro the enzymatic degradation of cross-linked starch microspheres. J Control Rel. 1998;55:193–201
  16. Andrianov AK, Payne LG. Polymeric carriers for oral uptake of microparticulates. Adv Drug Deliv Rev. 1998;34:155–170
  17. Schwick HG, Heide K. Immunochemistry and immunology of collagen and gelatin. Bibl Haematol. 1969;3:111–125
  18. Ward AG, Courts A. The cience and technology of gelatin. New York: Academic Press; 1977;
  19. Mladenovska K, Kumbaradzi EF, Dodov GM, Makraduli L, Goracinova K. Biodegradation and drug release studies of BSA loaded gelatin microspheres. Int J Pharm. 2002;242:247–249
  20. Coester CJ, Nayyare P, Samuel J. In vitro uptake of gelatin nanoparticles by murine dendritic cells and their intracellular localization. Eur J Pharm Biopharm. 2006;62:306–314
  21. Mitchell JP, Roberts DR, Langley J, Koentgen F, Lambert JN. A direct method for the formation of peptide and carbohydrate dendrimers. Bioorg Med Chem Lett. 1999;9:2785–2788
  22. Leo E, Vandelli MA, Cameroni R, Forni F. Doxorubicin-loaded gelatin nanoparticles stabilized by glutaraldehyde: involvement of the drug in the cross-linking process. Int J Pharm. 1997;155:75–82
  23. Gupta Y, Soni V, Chourasia MK, Jain A, Khare P, Jain SK. Targeted drug delivery to the brain via transferrin coupled liposomes. Drug Deliv Tech. 2005;5:66–71
  24. Liang WWX, Deshpande D, Malanga CJ, Rojanasakul Y. Oligonucleotide targeting to alveolar macrophages by mannose receptor mediated endocytosis. Biochim Biophys Acta. 1996;1279:227–233
  25. Oliveira AMC, Lowena TCR, Cabral L, Santos MEM, Rodrigues CR, Castro HC, et al. Development and validation of a HPLC-UV method for the determination in didanosine tablets. J Pharm Biomed Analysis. 2005;38:751–756
  26. Gupta Y, Jain A, Jain SK. Transferrin conjugated solid lipid nanoparticles for enhanced delivery of quinine dihydrochloride to the brain. J Pharm Pharmacol. 2007;59(7):935–940
  27. Gupta Y, Jain A, Jain P, Jain SK. Design and development of folate appended liposomes for enhanced delivery of 5-FU to tumour cells. J Drug Target. 2007;15:231-40.
  28. Marty JJ, Oppenheim RC, Speiser P. Nanoparticles: a new colloidal drug delivery system. Pharm Acta Helveticae. 1978;53:17–23
  29. Coester CJ, Langer K, Von Briesen H, Kreuter J. Gelatin nanoparticles by two step desolvation a new preparation method, surface modifications and cell uptake. J Microencap 2000;17:187-93.
  30. Holland SJ, Tighe BJ. Biodegradable polymers. In:  Garderton D,  Jones T editor. Advanced pharmaceutical sciences. vol. 6:New York: Academic Press; 1992;p. 101–164

 The authors are thankful to Hetro Laboratories (Hyderabad, India) for a gift sample of didanisone. The authors are grateful to the All India Institute of Medical Sciences, New Delhi, for providing the SEM facility.

PII: S1549-9634(07)00251-1

doi: 10.1016/j.nano.2007.11.004

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 1 , Pages 41-48 , March 2008

Article Tools

* Image Usage & Resolution