Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 1 , Pages 70-78 , March 2008

Anxiety and cognitive effects of quercetin liposomes in rats

  • Aroonsri Priprem, PhD

      Affiliations

    • Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen
    • Corresponding Author InformationCorresponding author: Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
  • ,
  • Jintanaporn Watanatorn, PhD

      Affiliations

    • Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
  • ,
  • Saengrawee Sutthiparinyanont, MSc

      Affiliations

    • Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen
  • ,
  • Wathita Phachonpai, MSc

      Affiliations

    • Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
  • ,
  • Supaporn Muchimapura, PhD

      Affiliations

    • Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

Received 20 March 2007 ,Accepted 7 December 2007.

References 

  1. Formica JV, Regelson W. Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol. 1995;33:1061–1080
  2. Bonina F, Lanza M, Montenegro L, Puglisi C, Tomaino A, Trombetta D, et al. Flavonoids as potential agents against photo-oxidative skin damage. Int J Pharm. 1996;145:87–94
  3. Steerenberg PA, Garssen J, Dortanta PM, van der Vlieta H, Geersea E, Verlaana APJ, et al. The effect of oral quercetin on UVB-induced tumor growth and local immunosuppression in SKH-1. Cancer Lett. 1997;114:187–189
  4. Skaper SD, Fabris M, Ferrari V, Dalle Carbonare M, Leon A. Quercetin protects cutaneous tissue-associated cell types including sensory neurons from oxidative stress induced by glutathione depletion: cooperative effects of ascorbic acid. Free Radic Biol Med. 1997;22:669–679
  5. Chen TJ, Jeng JY, Lin CW, Wu CY, Chen YC. Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells. Toxicology. 2006;223:113–126
  6. Chow JM, Shen SC, Huan SK, Lin HY, Chen YC. Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem Pharmacol. 2005;69:1839–1851
  7. Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharm Res. 2005;51:117–123
  8. Huang SL, Hsu CL, Yen GC. Growth inhibitory effect of quercetin on SW 872 human liposarcoma cells. Life Sci. 2006;79:203–209
  9. Cho JY, Kim IS, Jang YH, Kim AR, Lee SY. Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia. Neurosci Lett. 2006;404:330–335
  10. Wagner C, Fachinetto R, Corte CLD, Brito VB, Severo D, de Oliveira Costa Dias G, et al. Quercitrin, a glycoside form of quercetin, prevents lipid peroxidation in vitro. Brain Res. 2006;1107:192–198
  11. Joshi D, Naidu PS, Singh A, Kulkarni SK. Protective effect of quercetin on alcohol abstinence-induced anxiety and convulsions. Med Food. 2005;8:392–396
  12. Yankner BA. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 1996;16:921–932
  13. Multhaup G, Ruppert T, Schlicksupp A, Hesse L, Beher D, Masters CL, et al. Reactive oxygen species and Alzheimer's disease. Biochem Pharmacol. 1997;54:533–539
  14. Aruoma OI, Bahorun T, Jen LS. Neuroprotection by bioactive components in medicinal and food plant extracts. Mutat Res. 2003;544:203–215
  15. Boer VCJ, Dihal AA, van der Woude H, Arts ICW, Wolffram S, Alinket GM, et al. Tissue distribution of quercetin in rats and pigs. J Nutr. 2005;135:1617–1618
  16. Manach C, Morand C, Crespy V, Demigneè C, Texier O, Reègeèrat F, et al. Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett. 1998;426:331–336
  17. Youdim KA, Qaiser MZ, Begley DJ, Rice-Evans CA, Abbott NJ. Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radic Biol Med. 2004;36:592–604
  18. Bhattaram VA, Graefe U, Kohlert C, Veit M, Derendorf H. Pharmacokinetics and bioavailability of herbal medicinal products. Phytomedicine. 2002;9:1–33
  19. Behl CR, Pimplaskar HK, Sileno AP, de Meireles J, Romeo VD. Effects of physicochemical properties and other factors on systemic nasal drug delivery. Adv Drug Deliv Rev. 1998;29:89–116
  20. Mathison S, Nagilla R, Kompella UB. Nasal route for direct delivery of solutes to the central nervous system: fact or fiction?. J Drug Target. 1998;5:415–441
  21. Zhang Q, Jiang X, Jiang W, Lu W, Su L, Shi Z. Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain. Int J Pharm. 2004;275:85–96
  22. Illum L. Is nose-to-brain transport of drugs in man a reality?. J Pharm Pharmacol. 2004;56:3–17
  23. Talegaonkar S, Mishra PR. Intranasal delivery: an approach to bypass the blood brain barrier. Indian J Pharmacol. 2004;36:140–147
  24. Krauze L. Real-time imaging and quantification of brain delivery of liposomes. Pharm Res. 2006;23:2493–2504
  25. Sharma A, Sharma US. Liposomes in drug delivery: progress and limitations. Int J Pharm. 1997;154:123–140
  26. Cortesi R, Nastruzzi C. Liposomes, micelles and microemulsions as new delivery systems for cytotoxic alkaloids. Pharm Sci Tech Today. 1999;2:288–298
  27. Keller BC. Liposomes in nutrition. Trends Food Sci Technol. 2001;12:25–31
  28. Morris RGM, Garrud P, Rawlins JNP, O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature. 1982;297:681–683
  29. Priprem A, Rahman YE, Juhn SK, Lakkaraju A, Pituksuteepong T. A liposome-encapsulated ampicillin. Mahidol J. 1999;6:55–57
  30. Guo J, Ping Q, Jiang G, Huang L, Tong Y. Chitosan-coated liposomes: characterization and interaction with leuprolide. Int J Pharm. 2003;260:167–173
  31. Liang MT, Davies NM, Toth I. Encapsulation of lipopeptides within liposomes: effect of number of lipid chains, chain length and method of liposome preparation. Int J Pharm. 2005;301:247–254
  32. Zu Y, Li C, Fu Y, Zhao C. Simultaneous determination of catechin, rutin, quercetin kaempferol and isorhamnetin in the extract of sea buckthorn (Hippophae rhamnoides L.) leaves by RP-HPLC with DAD. J Pharm Biomed Anal. 2006;41:714–719
  33. Nii T, Ishii F. Encapsulation efficiency of water-soluble and insoluble drugs in liposomes prepared by the microencapsulation vesicle method. Int J Pharm. 2005;298:198–205
  34. Rouser G, Fleischer S, Yamamoto A. Two-dimensional thin-layer chromatographic separation of polar lipids and determination of phospholipids by phosphorous analysis of spots. Lipids. 1970;5:494–496
  35. van Dijk C, Driessen AJM, Recourt K. The uncoupling efficiency and affinity of flavonoids for vesicles. Biochem Pharmacol. 2000;60:1593–1600
  36. Lee M, Bailer UF, Frank GK, Henry SE, Meltzer CC, Price JC, et al. Relationship of a 5-HT transporter functional polymorphism to 5-HT1A receptor binding in healthy women. Mol Psychiatry. 2005;10:715–716
  37. Paulke A, Schubert-Zsilavecz M, Wurglics M. Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection. J Chromatogr B. 2006;832:109–113
  38. Metodiewa D, Jaiswal AK, Cenas N, Dickancaité E, Segura-Aguilar J. Quercetin may act as a cytotoxic prooxidant after its methanolic activation to semiquinone and quinoidal product. Free Radic Biol Med. 1999;26:107–116
  39. Lee JC, Kim J, Park JK, Chung GH, Jang YS. The antioxidant, rather than prooxidant, activities of quercetin on normal cells: quercetin protects mouse thymocytes from glucose oxidase-mediated apoptosis. Exp Cell Res. 2003;291:386–397

 No conflict of interest was reported by the authors of this paper.

 The researchers would like to thank the Integrated Nanotechnology Research Center (INRC). They also thank The National Research Council of Thailand (NRCT).

PII: S1549-9634(07)00253-5

doi: 10.1016/j.nano.2007.12.001

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 1 , Pages 70-78 , March 2008