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Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 2
, Pages 89-97
, June 2008
Nonviral gene transfection nanoparticles: function and applications in the brain
References
- . Gene therapy—promises, problems and prospects. Nature. 1997;389:239–242
- . Introduction to biophotonics. New York: Wiley-Interscience; 2004;
- . The impact of the completed human genome sequence on the development of novel therapeutics for human disease. Annu Rev Med. 2004;55:1–13
- . Cancer genes and the pathways they control. Nat Med. 2004;10:789–799
- . Genetic research and genetic information: a health information professional's perspective on the benefits and risks. Health Info Libr J. 2006;23:275–282
- . Biomedical applications of nanotechnology—implications for drug targeting and gene therapy. Trends Biotechnol. 1997;15:217–224
- . Intracellular trafficking of nonviral vectors. Gene Ther. 2005;12:1734–1751
- . Nuclear gene delivery: the Trojan horse approach. Expert Opin Drug Deliv. 2006;3:1–10
- . Gene therapy for neurological diseases. In: Templeton NS editors. Gene and cell therapy: therapeutic mechanisms and strategies. 2nd ed.. New York: Marcel Dekker; 2004;p. 601–627
- . The principles of gene therapy for the nervous system. Trends Neurosci. 1996;19:49–54
- . Human gene therapy. Nature. 1998;392(6679 Suppl):25–30
- . Retroviral insertional mutagenesis: past, present and future. Oncogene. 2005;24:7656–7672
- LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science. 2003;302:415–419
- . Biomedical applications of nanotechnology. Trends Biotechnol. 1997;15:217–224
- . Cancer risk prompts US to curb gene therapy. Nature. 2003;422:6927
- . FDA halts gene therapy trials after leukaemia case in France. BMJ. 2003;326:181
- . Virus treatment questioned after gene therapy death. Nature. 1999;517–518
- . Viral vectors as tools to model and treat neurodegenerative disorders. J Gene Med. 2005;7:530–539
- . Viral gene therapy. Clin Transl Oncol. 2006;8:858–867
- . Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum Gene Ther. 2001;12:861–870
- . DNA encapsulated magnesium and manganous phosphate nanoparticles: potential non-viral vectors for gene delivery. Biomaterials. 2005;26:2157–2163
- . Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. J Am Chem Soc. 2005;127:12492–12493
- . Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. Int J Pharm. 2003;250:25–33
- Optical tracking of organically modified silica nanoparticles as DNA carriers: a nonviral, nanomedicine approach for gene delivery. Proc Natl Acad Sci U S A. 2005;102:279–284
- . Multifunctional nanorods for gene delivery. Nat Mater. 2003;2:668–671
- A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro. Bioconjug Chem. 2000;11:926–932
- A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A. 1995;92:7297–7301
- Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci U S A. 1987;84:7413–7417
- . Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo. J Biol Chem. 1998;273:26164–26170
- . HER2-targeted gene transfer. Hum Gene Ther. 1997;8:719–727
- Tumor regression by targeted gene delivery to the neovasculature. Science. 2002;296:2404–2407
- . Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J Biol Chem. 1996;271:8481–8487
- Tumor-targeting nanoimmunoliposome complex for short interfering RNA delivery. Hum Gene Ther. 2006;17:117–124
- . Lipofection of cDNAs in the embryonic vertebrate central nervous system. Neuron. 1990;4:203–214
- . Plasmid DNAs directly injected into mouse brain with lipofectin can be incorporated and expressed by brain cells. Neurosci Lett. 1990;117:259–263
- . Significant behavioral recovery in Parkinson's disease model by direct intracerebral gene transfer using continuous injection of a plasmid DNA-liposome complex. Hum Gene Ther. 1998;9:1093–1102
- Liposome-mediated NGF gene transfection following neuronal injury: potential therapeutic applications. Gene Ther. 1999;6:994–1005
- . Tf-lipoplex-mediated NGF gene transfer to the CNS: neuronal protection and recovery in an excitotoxic model of brain injury. Gene Ther. 2005;12:1242–1252
- . Liposome-mediated transfer of the bcl-2 gene results in neuroprotection after in vivo transient focal cerebral ischemia in an animal model. Gene Ther. 2002;9:415–419
- . Noninvasive gene targeting to the brain. Proc Natl Acad Sci U S A. 2000;97:7567–7572
- . Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter. Hum Gene Ther. 2004;15:339–350
- . A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum Gene Ther. 1996;7:1947–1954
- Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Ther. 1998;5:712–717
- Preferential transfection of adult mouse neural stem cells and their immediate progeny in vivo with polyethylenimine. Mol Cell Neurosci. 2002;19:165–174
- Loss of basic fibroblast growth factor in substantia nigra neurons in Parkinson's disease. Neurology. 1993;43:372–376
- Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors. Mol Biol Cell. 2001;12:449–462
- Integrative nuclear FGFR1 signaling (INFS) pathway mediates activation of the tyrosine hydroxylase gene by angiotensin II, depolarization and protein kinase C. J Neurochem. 2002;81:506–524
- Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine. Brain Res Mol Brain Res. 2005;139:361–366
- Assessment of viral and non-viral gene transfer into adult rat brains using HSV-1, calcium phosphate, and PEI-based methods. Folia Morphol (Warsz). 2005;64:130–144
- . Radical directions in Parkinson's disease. Nat Med. 1995;1:201–203
- . Schizophrenia: from phenomenology to neurobiology. Neurosci Biobehav Rev. 2003;27:269–306
- Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain. Proc Natl Acad Sci U S A. 2005;102:11539–11544
- . No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. Proc Natl Acad Sci U S A. 2004;101:10177–10182
- Gene transfer into the central nervous system using herpes simplex virus-1 vectors. Folia Morphol (Warsz). 2000;59:221–232
- . Peripheral blood stem cells for allografting. Blood. 1995;85:1413–1415
- . Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia. Proc Natl Acad Sci U S A. 1993;90:2074–2077
- Integrative nuclear FGFR1 signaling (INFS) as a part of a universal “feed-forward-and-gate” signaling module that controls cell growth and differentiation. J Cell Biochem. 2003;90:662–691
- ORMOSIL nanoparticles as a non-viral gene delivery vector for modeling polyglutamine induced brain pathology. J Neurosci Methods. 2007;165:230–243
This study was supported by grants from the National Institutes of Health (NIH CA119397, NIH CA104492), the John R. Oishei Foundation, the Chemistry and Life Sciences Division of the Air Force Office of Scientific Research, and the University at Buffalo Interdisciplinary Research and Creative Activities Fund. Support from the Center of Excellence in Bioinformatics and Life Sciences is also acknowledged.
PII: S1549-9634(08)00003-8
doi: 10.1016/j.nano.2008.01.002
Next »
Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 2
, Pages 89-97
, June 2008
