Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 2 , Pages 146-154 , June 2008

N-hexanoyl chitosan-stabilized magnetic nanoparticles: enhancement of adenoviral-mediated gene expression both in vitro and in vivo

  • Shanta Raj Bhattarai, PhD

      Affiliations

    • Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan, USA
    • ,
  • Sun Young Kim, PhD

      Affiliations

    • Department of Pediatrics and Research Institute of Clinical Medicine, School of Medicine, Chonbuk National University, Jeonju, South Korea
    • ,
  • Kyu Yun Jang, MD, PhD

      Affiliations

    • Department of Pathology, School of Medicine, Chonbuk National University, Jeonju, South Korea
    • ,
  • Ki Chang Lee, PhD

      Affiliations

    • Department of Veterinary Radiology, School of Veterinary Medicine, Chonbuk National University, Jeonju, South Korea
    • ,
  • Ho Keun Yi, PhD

      Affiliations

    • Department of Biochemistry, School of Dentistry, Chonbuk National University, Jeonju, South Korea
    • ,
  • Dae Yeol Lee, MD, PhD

      Affiliations

    • Department of Pediatrics and Research Institute of Clinical Medicine, School of Medicine, Chonbuk National University, Jeonju, South Korea
    • ,
  • Hak Yong Kim, PhD

      Affiliations

    • Department of Textile Engineering, Chonbuk National University, Jeonju, South Korea
    • ,
  • Pyoung Han Hwang, MD, PhD

      Affiliations

    • Department of Pediatrics and Research Institute of Clinical Medicine, School of Medicine, Chonbuk National University, Jeonju, South Korea
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Chonbuk National University, 634-18 Geumam-dong, Deokjin-gu, Jeonju, Jeonbuk 561-712, Korea.

Received 25 August 2007 ,Accepted 8 February 2008.

References 

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  5. Fields BN. AdenoViruses: the viruses and their replication. In:  Fields BN,  Knipe DM,  Howley PM editor. Fields virology. 3rd ed.. Philadelphia: Lippincott-Raven Publishers; 1996;p. 2111–2148
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  9. Huth S, Lausier J, Gersting SW, Rudolph C, Plank C, Welsch U, et al. Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer. J Gene Med. 2004;6:923–936
  10. Bhattarai SR, Kc RB, Aryal S, Khil MS, Kim HY. N-acylated chitosan stabilized iron oxide nanoparticles as a novel nano-matrix and ceramic modification. Carbohydrate Polymer. 2007;69:467–477
  11. Remant Bahadur KC, Aryal S, Bhattarai SR, Bhattarai N, Kim CH, Kim HY. Stabilization of gold nanoparticles by hydrophobically modified polycations. J Biomaterials Sci Polymer Ed. 2006;7:579–589
  12. Bhattarai SR, Remant Bahadur KC, Aryal S, Bhattarai N, Kim SY, Lee HY, et al. Hydrophobically modified chitosan/gold nanoparticles for DNA delivery. J Nanopart Res. 2008;10:151–162
  13. Bhattarai SR, Kim SY, Jang KY, Yi HK, Lee YH, Bhattarai N, et al. Amphiphilic triblock copolymer poly (p-dioxanone-co-l-lactide)-block-poly(ethylene glycol), enhancement of gene expression and inhibition of lung metastasis by aerosol delivery. Gene Ther. 2007;14:476–483
  14. Bhattarai SR, Yi HK, Bhattarai N, Hwang PH, Kim HY. Novel block copolymer (PDO/LLA-b-PEG-); enhancement of DNA uptake and cell transfection. Acta Biomaterialia. 2006;2:207–212
  15. Bhattarai SR, Bhattarai N, Yi HK, Hwang PH, Cha DI, Kim HY. Novel biodegradable electrospun membrane: scaffold for tissue engineering. Biomaterials. 2003;25:2595–2602
  16. Cheng FY, Su CH, Yang YS, Yeh CS, Tsai CY, Wu CL, et al. Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications. Biomaterials. 2005;26:729–738
  17. Kim DK, Mikhaylova M, Zhang Y, Muhammed M. Protective coating of superparamagnetic iron oxide nanoparticles. Chem Mater. 2003;15:1617–1627
  18. Woo K, Hong J, Choi S, Lee HW, Ahn JP, Kim CS, et al. Easy synthesis and magnetic properties of iron oxide nanoparticles. Chem Mater. 2004;16:2814–2818
  19. Bhattarai SR, Kc RB, Kim SY, Sharma M, Khil MS, Hwang PH, et al. N-hexanoyl chitosan–stabilized magnetic nanoparticles: implication for cellular labeling and magnetic resonance imaging. J Nanobiol. 2008;6:1–30
  20. Bhattarai SR, Kim SY, Jang KY, Lee KC, Yi HK, Lee DY, et al. Laboratory formulated magnetic nanoparticles for enhancement of viral gene expression in suspension cell line. J Virol Methods. 2008;147:213–218

 The work was supported in part by research funds of Chonbuk National University in 2006 (BS-2006-18).

PII: S1549-9634(08)00031-2

doi: 10.1016/j.nano.2008.02.001

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 2 , Pages 146-154 , June 2008

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