Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 3 , Pages 208-214 , September 2008

Uptake of oleoyl-chitosan nanoparticles by A549 cells

  • Jing Zhang, PhD

      Affiliations

    • College of Marine Life Science, Ocean University of China, Qingdao, P.R. China
    • ,
  • Xi Guang Chen, PhD

      Affiliations

    • College of Marine Life Science, Ocean University of China, Qingdao, P.R. China
    • Corresponding Author InformationCorresponding author. College of Marine Life Science, Ocean University of China, Qingdao, P.R. China.
    • ,
  • Wei Bing Peng, PhD

      Affiliations

    • College of Medicine and Pharmacy, Ocean University of China, Qingdao, P.R. China
    • ,
  • Cheng Sheng Liu, PhD

      Affiliations

    • College of Marine Life Science, Ocean University of China, Qingdao, P.R. China

Received 24 December 2007 ,Accepted 20 March 2008.

References 

  1. Oyewumi MO, Mumper RJ. Influence of formulation parameters on gadolinium entrapment and tumor cell uptake using folate-coated nanoparticles. Int J Pharm. 2003;251:85–97
  2. Jenning V, Gysler A, Schafer-Korting M, Gohla SH. Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm. 2000;49:211–218
  3. Coester CJ, Langer K, Briessen HV, Kreuter J. Gelatin nanoparticles by two step desolvation—a new preparation method, surface modifications and cell uptake. J Microencapsul. 2000;17:187–193
  4. Stella B, Arpicco S, Peracchia MT, Desmaele D, Hoebeke J, Renoir M, et al. Design of folic acid–conjugated nanoparticles for drug targeting. J Pharm Sci. 2000;89:1452–1464
  5. Gupta AK, Gupta M, Yarwood SJ, Curtis ASG. Effect of cellular uptake of gelatin nanoparticles on adhesion, morphology and cytoskeleton organisation of human fibroblasts. J Control Release. 2004;95:197–207
  6. Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: theory to practice. Pharm Rev. 2001;53:283–318
  7. Ramge P, Unger RE, Oltrogge JB, Zenker D, Begley D, Kreuter J, et al. Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells. Eur J Neurol. 2000;12:1931–1940
  8. Hashida M, Nishikawa M, Takakura Y. Receptor-mediated cell specific delivery of drugs to the liver and kidney. In:  Ogata N,  Kim SW,  Feijen J,  Okano T editor. Advanced biomaterials in biomedical engineering and drug delivery systems. Tokyo, Japan: Springer-Verlag; 1996;p. 86–90
  9. Wattiaux R, Laurent N, Conninck SW, Jadot M. Endosomes, lysosomes: their implications in gene transfer. Adv Drug Deliv Rev. 2000;41:201–208
  10. Illum L, Jabbal-Gill I, Hinchcliffe M, Fisher AN, Davis SS. Chitosan as a novel nasal delivery system for vaccines. Adv Drug Deliv Rev. 2001;51:81–96
  11. Janes KA, Fresneau MP, Marazuela A, Fabra A, Alonso MJ. Chitosan nanoparticles as delivery systems for doxorubicin. J Control Release. 2001;73:255–267
  12. Zhang J, Chen XG, Li YY, Liu CS. Self-assembled nanoparticles based on hydrophobically modified chitosan as carriers for doxorubicin. Nanomedicine. 2007;3:258–265
  13. Lamprecht A, Benoit JP. Etoposide nanocarriers suppress glioma cell growth by intracellular drug delivery and simultaneous P-glycoprotein inhibition. J Control Release. 2006;112:208–213
  14. Khin YW, Feng SS. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials. 2005;26:2713–2722
  15. Florence AT, Hillery AM, Hussain N, Jani PU. Nanoparticles as carriers for oral peptide absorption: studies on particle uptake and fate. J Control Release. 1995;36:39–46
  16. Zhang LK, Hou SX, Mao SJ, Wei DP, Song XG, Lu Y. Uptake of folate-conjugated albumin nanoparticles to the SKOV3 cells. Int J Pharm. 2004;287:155–162
  17. Huang M, Ma ZS, Khor E, Lim LY. Uptake of FITC-chitosan nanoparticles by A549 cells. Pharm Res. 2002;19:1488–1494
  18. Delie F. Evaluation of nano- and microparticle uptake by the gastrointestinal tract. Adv Drug Deliv Rev. 1998;34:221–223
  19. Suh K, Jeong B, Liu F, Kim SW. Cellular uptake study of biodegradable nanoparticles in muscular smooth cells. Pharm Res. 1998;12:1495–1498
  20. Li YY, Chen XG, Yu LM, Wang SX, Sun GZ, Zhou HY. Aggregation of hydrophobically modified chitosan in solution and at the air-water interface. J Appl Polym Sci. 2006;102:1968–1973
  21. Wan L, Hu FQ, Yuan H. Study of the uptake of chitosan oligosaccharide nanoparticles by A549 cells. Acta Pharm Sinica. 2004;39:227–231
  22. Chen XG, Lee CM, Park HJ. O/W emulsification for the self-aggregation and nanoparticle formation of linoleic acid–modified chitosan in the aqueous system. J Agric Food Chem. 2003;51:3135–3139
  23. Rubinstein LV, Shoemaker RH, Paull KD, Simon RM, Tosini S, Skehan P, et al. Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst. 1990;82:1113–1117
  24. Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, et al. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst. 1990;82:1107–1112
  25. Jung T, Kamm W, Breitenbach A, Kaiserling E, Xiao JX, Kissel T. Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?. Eur J Pharm Biopharm. 2000;50:147–160
  26. Schnitzer JE. Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivo. Adv Drug Deliv Rev. 2001;49:265–280
  27. Li YY, Chen XG, Liu CS, Cha DS, Park HJ, Lee CM. Effect of the molecular mass and degree of substitution of oleoylchitosan on the structure, rheological properties, and formation of nanoparticles. J Agric Food Chem. 2007;55:4842–4847
  28. Suh H, Jeong B, Liu F, Kim SW. Cellular uptake study of biodegradable nanoparticles in vascular smooth muscle cells. Pharm Res. 1998;15:1495–1498
  29. Schipper NGM, Olsson S, Hoogstraate JA, deBoer AG, Vårum KM, Artursson P. Chitosans as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement. Pharm Res. 1997;14:923–929
  30. Desai MP, Labhasetwar V, Walter E, Levy RJ, Amidon GL. The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm Res. 1997;14:1568–1573
  31. Foster KA, Yazdanian M, Audus KL. Microparticulate uptake mechanisms of in-vitro cell culture models of the respiratory epithelium. J Pharm Pharmacol. 2001;53:57–66
  32. Couvreur P, Puisieux F. Nano- and microparticles for the delivery of polypeptides and proteins. Adv Drug Del Rev. 1993;10:141–162
  33. Jayanth P, Sanjeeb K, Swayam P, Tom B, Vinod L. Fluorescence and electron microscopy probes for cellular and tissue uptake of poly(d,l-lactide-co-glycolide) nanoparticles. Int J Pharm. 2003;262:1–11

 This work was supported by grants from National Natural Science Foundation of China (NSFC) (30770582) and International Science and Technology Cooperation Project (ISTCP) (2006DFA33150).

PII: S1549-9634(08)00040-3

doi: 10.1016/j.nano.2008.03.006

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 3 , Pages 208-214 , September 2008

Article Tools

* Image Usage & Resolution