Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 3 , Pages 241-251 , September 2008

Anti-inflammatory activity of nanocrystalline silver in a porcine contact dermatitis model

  • Patricia L. Nadworny, BSc

      Affiliations

    • Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada
    • Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • JianFei Wang, PhD

      Affiliations

    • Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Edward E. Tredget, MD, MSc, FRCSC

      Affiliations

    • Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Robert E. Burrell, PhD

      Affiliations

    • Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada
    • Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    • Corresponding Author InformationCorresponding author. 1101 Research Transition Facility, University of Alberta, Edmonton, Alberta, Canada T6G 2V2.

Received 24 August 2007 ,Accepted 13 April 2008.

References 

  1. Olson ME, Wright JB, Lam K, Burrell RE. Healing of porcine donor sites covered with silver-coated dressings. Eur J Surg. 2000;166:486–489
  2. Wright JB, Lam K, Buret AG, Olson ME, Burrell RE. Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing. Wound Repair Regen. 2002;10:141–151
  3. Kirsner RS, Orsted H, Wright JB. Matrix metalloproteinases in normal and impaired wound healing: a potential role of nanocrystalline silver. Wounds. 2002;13:4–12
  4. Bhol KC, Alroy J, Schechter PJ. Anti-inflammatory effect of topical nanocrystalline silver cream on allergic contact dermatitis in a guinea pig model. Clin Exp Dermatol. 2004;29:282–287
  5. Bhol KC, Schechter PJ. Topical nanocrystalline silver cream suppresses inflammatory cytokines and induces apoptosis of inflammatory cells in a murine model of allergic contact dermatitis. Br J Dermatol. 2005;152:1235–1242
  6. Demling RH, Burrell RE. The beneficial effects of nanocrystalline silver as a topical antimicrobial agent. Leadership Medica. 2002;16(7):1–10
  7. Birringer R. Nanocrystalline materials. Mater Sci Eng. 1989;A117:33–43
  8. Fan FF, Bard AJ. Chemical, electrochemical, gravimetric, and microscopic studies on antimicrobial silver films. J Phys Chem B. 2002;106:279–287
  9. Fuertes MA, Castilla J, Alonso C, Perez JM. Cisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways. Curr Med Chem. 2003;10:257–266
  10. Mizushima Y, Okumura H, Kasukawa R. Effects of gold and platinum on necrotizing factor, skin sensitizing antibody, and complement. Jpn J Pharmacol. 1965;15:131–134
  11. Handel ML, Nguyen LQ, Lehmann TP. Inhibition of transcription factors by anti-inflammatory and anti-rheumatic drugs: can variability in response be overcome?. Clin Exp Pharmacol Physiol. 2000;27:139–144
  12. Suzuki S, Okubo M, Kaise S, Ohara M, Kasukawa R. Gold sodium thiomalate selectivity inhibits interleukin-5-mediated eosinophil survival. J Allergy Clin Immunol. 1995;96:251–256
  13. Eisler R. Chrysotherapy: a synoptic review. Inflamm Res. 2003;52:487–501
  14. Abraham GE, Himmel PB. Management of rheumatoid arthritis: rationale for the use of colloidal metallic gold. J Nutr Env Med. 1997;7:295–305
  15. Zou J, Guo Z, Parkinson JA, Chen Y, Sadler PJ. Gold(III)-induced oxidation of glycine: relevance to the toxic side-effects of gold drugs. J Inorg Biochem. 1999;74:352
  16. Bayler A, Schier A, Bowmaker GA, Schmidbaur H. Gold is smaller than silver, crystal structures of [bis(trimesitylphosphine)gold(I)] and [bis(trimesitylphosphine)silver(I)] tetrafluoroborate. J Am Chem Soc. 1996;118:7006–7007
  17. Pauling L. In: The nature of the chemical bond. 3rd ed.. Ithaca: Cornell University Press; 1980;p. 410
  18. Wyckhoff RG. In: 2nd ed.. Crystal structures. vol. 1:New York: Interscience Publishers; 1958;p. 10
  19. Tian J, Wong KK, Ho CM, Lok CN, Yu WY, Che CM, et al. Topical delivery of silver nanoparticles promotes wound healing. ChemMedChem. 2007;2:129–136
  20. Moyer CA, Brentano L, Gravens DL, Margraf HW, Monafo WW. Treatment of large human burns with 0.5% silver nitrate solution. Arch Surg. 1965;90:812–867
  21. Meyer W, Schwarz R, Neurand K. The skin of domestic mammals as a model for the human skin, with special reference to the domestic pig. Curr Probl Dermatol. 1978;7:39–52
  22. Wang JF, Olson ME, Reno CR, Kulyk W, Wright JB, Hart DA. Molecular and cell biology of skin wound healing in a pig model. Connect Tissue Res. 2000;41:195–211
  23. Wang JF, Olson ME, Reno CR, Wright JB, Hart DA. The pig as a model for excisional skin wound healing: characterization of the molecular and cellular biology, and bacteriology of the healing process. Comp Med. 2001;51:341–348
  24. Burrell RE, Morris LR. Anti-microbial coating for medical device. United States patent US 5753251. 1998 May 19.
  25. Taylor PL, Ussher AL, Burrell RE. Impact of heat on nanocrystalline silver dressings. Part I: Chemical and biological properties. Biomaterials. 2005;26:7221–7229
  26. Taylor PL, Omotoso O, Wiskel JB, Mitlin D, Burrell RE. Impact of heat on nanocrystalline silver dressings. Part II: Physical properties. Biomaterials. 2005;26:7230–7240
  27. Scott AE, Kashon ML, Yucesoy B, Luster MI, Tinkle SS. Insights into the quantitative relationship between sensitization and challenge for allergic contact dermatitis reactions. Toxicol Appl Pharmacol. 2002;183:66–70
  28. Laidlaw A, Flecknell P, Rees JL. Production of acute and chronic itch with histamine and contact sensitizers in the mouse and guinea pig. Exp Dermatol. 2002;11:285–291
  29. Groth O, Skoog ML. Measurement and differentiation of the cellular infiltrate in experimental allergic contact dermatitis. Acta Derm Venereol. 1979;59:129–134
  30. Kelley KW, Curtis SE, Marzan GT, Karara HM, Anderson CR. Body surface area of female swine. J Anim Sci. 1973;36:927–930
  31. Woods A. Hematoxylin and counterstains. In:  Woods AE,  Ellis RC editor. Laboratory histopathology: a complete reference. New York: Churchill Livingstone; 1994;(http://www.adam.com.au/royellis/haem.html)
  32. Korostoff JM, Wang JF, Sarment DP, Stewart JC, Feldman RS, Billings PC. Analysis of in situ protease activity in chronic adult periodontitis patients: expression of activated MMP-2 and a 40 kDa serine protease. J Periodontol. 2000;71:353–360
  33. Grabbe S, Schwarz T. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol Today. 1998;19:37–44
  34. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol. 2005;6:1191–1197
  35. Rigobello MP, Scutari G, Boscolo R, Bindoli A. Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative. Br J Pharmacol. 2002;136:1162–1168
  36. Glennas A, Rugstad HE. Ploidity and cell cycle progression during treatment with gold chloride, auranofin and sodium aurothiomalate. Studies on a human epithelial cell line and its sub-strains made resistant to the antiproliferative effects of these gold compounds. Virchows Arch B Cell Pathol Incl Mol Pathol. 1985;49:385–393
  37. Bragg PD, Rainnie DJ. The effect of silver ions on the respiratory chain of Escherichia coli. Can J Microbiol. 1974;20:883–889
  38. Dunn K, Edwards-Jones V. The role of Acticoat with nanocrystalline silver in the management of burns. Burns. 2004;30:S1–S9
  39. Denecker G, Vercammen D, Declercq W, Vandenabeele P. Apoptotic and necrotic cell death induced by death domain receptors. Cell Mol Life Sci. 2001;58:356–370
  40. Almofti MR, Ichikawa T, Yamashita K, Terada H, Shinohara Y. Silver ion induces a cyclosporine a-insensitive permeability transition in rat liver mitochondria and release of apoptogenic cytochrome c. J Biochem (Tokyo). 2003;134:43–49
  41. Effendy I, Loffler H, Maibach HI. Epidermal cytokines in murine cutaneous irritant responses. J Appl Toxicol. 2000;20:335–341
  42. Girolomoni G, Pastore S, Albanesi C, Cavani A. Targeting tumour necrosis factor-alpha as a potential therapy in inflammatory skin diseases. Curr Opin Investig Drugs. 2002;3:1590–1595
  43. Wahl SM. Transforming growth factor-beta: innately bipolar. Curr Opin Immunol. 2007;19:55–62
  44. Li AG, Lu SL, Han G, Hoot KE, Wang XJ. Role of TGFbeta in skin inflammation and carcinogenesis. Mol Carcinog. 2006;45:389–396
  45. Stockley RA. Neutrophils and protease/antiprotease imbalance. Am J Respir Crit Care Med. 1999;160:S49–S52
  46. Teixeira LR, Vargas FS, Acencio MM, Paz PF, Antonangelo L, Vaz MA, et al. Influence of anti-inflammatory drugs (methylprednisolone and diclofenac sodium) on experimental pleurodesis induced by silver nitrate or talc. Chest. 2005;128:4041–4045
  47. Fyfe MC, Chahl LA. The effect of single or repeated applications of “therapeutic” ultrasound on plasma extravasation during silver nitrate induced inflammation of the rat hindpaw ankle joint in vivo. Ultrasound Med Biol. 1985;11:273–283
  48. Chahl JS, Chahl LA. The role of prostaglandins in chemically induced inflammation. Br J Exp Pathol. 1976;57:689–695

 This research was supported by Natural Sciences and Engineering Research Council of Canada (NSERC) Canada Research Chair (R.B.); Alberta Heritage Foundation for Medical Research, Firefighter Burns Trust Fund of the University of Alberta (E.E.T.); NSERC, Alberta Ingenuity Fund, and Killam Memorial Scholarship (P.L.N.).

PII: S1549-9634(08)00045-2

doi: 10.1016/j.nano.2008.04.006

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 3 , Pages 241-251 , September 2008

Article Tools

* Image Usage & Resolution