Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 3 , Pages 201-207, September 2008

Gadolinium-conjugated TiO2-DNA oligonucleotide nanoconjugates show prolonged intracellular retention period and T1-weighted contrast enhancement in magnetic resonance images

  • Tatjana Paunesku, PhD

      Affiliations

    • Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    • Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA
    • Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    • ,
  • Tianyi Ke, PhD

      Affiliations

    • Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah, USA
    • ,
  • Rohan Dharmakumar, PhD

      Affiliations

    • Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    • ,
  • Nicole Mascheri, MS

      Affiliations

    • Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    • ,
  • Aiguo Wu, PhD

      Affiliations

    • Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    • ,
  • Barry Lai, PhD

      Affiliations

    • X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois, USA
    • ,
  • Stefan Vogt, PhD

      Affiliations

    • X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois, USA
    • ,
  • Jörg Maser, PhD

      Affiliations

    • X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois, USA
    • ,
  • Kenneth Thurn, BS

      Affiliations

    • Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    • ,
  • Barbara Szolc-Kowalska, MD

      Affiliations

    • Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    • ,
  • Andrew Larson, PhD

      Affiliations

    • Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    • ,
  • Raymond C. Bergan, PhD

      Affiliations

    • Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA
    • Department of Medicine, Northwestern University, Chicago, Illinois, USA
    • ,
  • Reed Omary, MD, MS

      Affiliations

    • Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA
    • Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    • ,
  • Debiao Li, PhD

      Affiliations

    • Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    • ,
  • Zheng-Rong Lu, PhD

      Affiliations

    • Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah, USA
    • ,
  • Gayle E. Woloschak, PhD

      Affiliations

    • Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    • Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA
    • Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    • Department of Cell and Molecular Biology, Northwestern University, Chicago, Illinois, USA
    • Corresponding Author InformationCorresponding author. Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA.

Received 15 September 2007; accepted 13 April 2008. published online 24 June 2008.

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 This work was supported in part by the following National Institutes of Health grants: CA107467, EB002100, P50 CA89018, U54CA119341; by Department of Energy (DOE) grant FG02-04 ER 63920; and by Siemens Medical Solutions. Use of the Advanced Photon Source was supported by the US DOE, Office of Science, Office of Basic Energy Sciences, under Contract No. W-31-109-Eng-38.

PII: S1549-9634(08)00046-4

doi:10.1016/j.nano.2008.04.004

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 3 , Pages 201-207, September 2008

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