Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 4 , Pages 318-329 , December 2008

Nanoimmunoliposome delivery of superparamagnetic iron oxide markedly enhances targeting and uptake in human cancer cells in vitro and in vivo

  • Chengli Yang, PhD

      Affiliations

    • Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC
    • ,
  • Antonina Rait, PhD

      Affiliations

    • Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC
    • ,
  • Kathleen F. Pirollo, PhD

      Affiliations

    • Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC
    • ,
  • John A. Dagata, PhD

      Affiliations

    • National Institute of Standards and Technology, Gaithersburg, MD, USA
    • ,
  • Natalia Farkas, PhD

      Affiliations

    • National Institute of Standards and Technology, Gaithersburg, MD, USA
    • ,
  • Esther H. Chang, PhD

      Affiliations

    • Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC
    • Corresponding Author InformationCorresponding author. Department of Oncology, Lombardi Comprehensive Cancer Center TRB/E420, Georgetown University Medical Center, Washington, DC, USA.

Received 29 September 2007 ,Accepted 20 May 2008.

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 This work was supported by a National Cancer Institute (NCI) grant 5R01CA132012-02 (E.H.C.) and a research grant from SynerGene Therapeutics, Inc. (SGT) (K.F.P.). These studies were conducted in part using the Microscopy and Imaging, Histopathology and Tissue, and Animal Core Facilities supported by NCI Cancer Center Support grant and US Public Health Service grant 2P30-CA-51008 and 1 S10 RR 15768-01. This investigation was performed in part in a facility constructed with support from Research Facilities Improvement grant C06RR14567 from the National Center for Research Resources, National Institutes of Health. A.R. is a consultant for SGT; E.H.C. is a consultant for SGT, in which she has significant personal financial interest. SGT had no involvement in study design; in the collection, analysis, or interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

PII: S1549-9634(08)00085-3

doi: 10.1016/j.nano.2008.05.004

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 4, Issue 4 , Pages 318-329 , December 2008

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