Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 1 , Pages 21-29, March 2009

Anti-glycation activity of gold nanoparticles

  • Santiswarup Singha, MSc

      Affiliations

    • Department of Biochemistry, Calcutta University, Kolkata, India
    • ,
  • Jaydeep Bhattacharya, PhD

      Affiliations

    • Department of Biochemistry, Calcutta University, Kolkata, India
    • ,
  • Himadri Datta, MS, PhD

      Affiliations

    • Regional Institute of Ophthalmology, Calcutta Medical College, Kolkata, India
    • ,
  • Anjan Kumar Dasgupta, PhD

      Affiliations

    • Department of Biochemistry, Calcutta University, Kolkata, India
    • Corresponding Author InformationCorresponding author. Calcutta University, Kolkata, WB 700019, India.

Received 11 March 2008; accepted 7 June 2008. published online 28 July 2008.

Abstract 

Anti-glycation activity of gold nanoparticles (GNPs) has been reported for the first time. Nonenzymatic glycation of α-crystallin leads to formation of cataract, or opaque aggregate of proteins. In this article we report prevention of glycation of α-crystallin by conjugation with GNPs. Formation of advanced glycosylic end products is prevented even if a strong glycating agent such as fructose is used. In addition, the nanoconjugation can provide some important information on the structural distribution of this dynamic chaperone protein. Because GNPs are biocompatible, their reported anti-glycation activity may have ophthalmological implications.

Key words: α-Crystallin, Gold nanoparticle, Aggregation, Chaperone, Glycation, Anti-glycating agent

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 Sources of support include Grant No. BT/PR9953/MNT/28/73/2007, Department of Biotechnology (DBT), Government of India.

PII: S1549-9634(08)00090-7

doi:10.1016/j.nano.2008.06.005

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 1 , Pages 21-29, March 2009

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