Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 1 , Pages 64-72 , March 2009

Atomic force microscopy probing platelet activation behavior on titanium nitride nanocoatings for biomedical applications

  • Varvara Karagkiozaki, MD, MSc

      Affiliations

    • Department of Physics, Laboratory for Thin Films—Nanosystems and Nanometrology (LTFN), Aristotle University of Thessaloniki, Thessaloniki, Greece
    • Medical School, AHEPA University General Hospital, First Cardiology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
    • ,
  • Stergios Logothetidis, PhD

      Affiliations

    • Department of Physics, Laboratory for Thin Films—Nanosystems and Nanometrology (LTFN), Aristotle University of Thessaloniki, Thessaloniki, Greece
    • Corresponding Author InformationCorresponding author.
    • ,
  • Nikolaos Kalfagiannis, MSc

      Affiliations

    • Department of Physics, Laboratory for Thin Films—Nanosystems and Nanometrology (LTFN), Aristotle University of Thessaloniki, Thessaloniki, Greece
    • ,
  • Sylvie Lousinian, MSc

      Affiliations

    • Department of Physics, Laboratory for Thin Films—Nanosystems and Nanometrology (LTFN), Aristotle University of Thessaloniki, Thessaloniki, Greece
    • ,
  • Georgios Giannoglou, PhD

      Affiliations

    • Medical School, AHEPA University General Hospital, First Cardiology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece

Received 27 December 2007 ,Accepted 24 July 2008.

References 

  1. Yang P, Huang N, Leng YX, Chen JY, Fu KY, Kwok SCH, et al. Activation of platelets adhered on amorphous hydrogenated carbon films synthesized by plasma immersion ion implantation-deposition. Biomaterials. 2003;24:2821–2829
  2. Bollen LS, Svendsen O. Biocompatibility. Regulatory guidelines for biocompatibility safety testing. Medical Plastics and Biomaterials [serial on the Internet]. Available from: http://www.devicelink.com/mpb/archive/97/05/001.html1997;
  3. Hauert R. A review of modified DLC coatings for biological applications. Diam Relat Mater. 2003;12:583–589
  4. Braet F, Seynaeve C, De Zanger R, Wisse E. Imaging surface and submembranous structures with the atomic force microscope: a study on living cancer cells, fibroblasts and macrophages. J Microsc. 1998;190:328–338
  5. Müller D, Anderson K. Biomolecular imaging using atomic force microscopy. Trends Biotechnol. 2002;20:545–549
  6. Muratore C, Hu J, Voevodin A. Adaptive nanocomposite coatings with a titanium nitride diffusion barrier mask for high-temperature tribological applications. Thin Solid Films. 2007;515:3638–3643
  7. Matenoglou G, Logothetidis S, Kassavetis S. Durable TiN/TiNx metallic contacts for solar cells. Thin Solid Films. 2006;511–512:453–456
  8. Ferrari F, Miotello A, Pavloski L, Galvanetto E, Moschini G, Galassini S. Metal-ion release from titanium and TiN coated implants in rat bone. Nucl Instr Meth Phys Res B Beam Interact Mater Atoms. 1993;79:421–423
  9. BryCoat Advanced Metallurgical Coatings [home page on the Internet]. BryCoat titanium nitride (TiN) coatings. Available from: <http://www.brycoat.com/pvd-tin-chart.html>2000;
  10. Mc Namee C, Pyo N, Tanaka S, Kanda Y, Higashitani K. Imaging of a soft, weakly adsorbing, living cell with a colloid probe tapping atomic force microscope technique. Colloids Surf B Biointerfaces. 2006;47:85–89
  11. Kwok S, Wang J, Chu P. Surface energy, wettability, and blood compatibility phosphorus doped diamond-like carbon films. Diam Relat Mater. 2005;14:78–85
  12. Saito T, Hasebe T, Yohena S, Matsuoka Y, Kamijo A, Takahashi A, et al. Antithrombogenicity of fluorinated diamond-like carbon films. Diam Relat Mater. 2005;14:1116–1119
  13. Ohm D, Kwangmeyung K, Youngro B. Covalently grafted phospholipid monolayer on silicone catheter surface for reduction in platelet adhesion. Biomaterials. 2005;26:7115–7123
  14. Fritz M, Radmacher M, Gaub HE. Granula motion and membrane spreading during activation of human platelets imaged by atomic force microscopy. Biophys J. 1994;66:1328–1334
  15. JCPDS Powder Diffraction File No.76-2494, JCPDS Powder Diffraction File No. 38-1420.
  16. Patsalas P, Gravalidis C, Logothetidis S. Surface kinetics and subplantation phenomena affecting the texture, morphology, stress, and growth evolution of titanium nitride films. J Appl Phys. 2004;96:6234–6246
  17. Patsalas P, Logothetidis S. Optical, electronic, and transport properties of nanocrystalline titanium nitride thin films. J Appl Phys. 2001;90:4725–4734
  18. Azzam RMA, Bashara NM. Applications of ellipsometry. In: Ellipsometry and polarized light. 1977;p. 428–429Amsterdam: North Holland Publishing
  19. Logothetidis S, Alexandrou I, Papadopoulos A. In situ spectroscopic ellipsometry to monitor the process of TiNx thin films deposited by reactive sputtering. J Appl Phys. 1995;3:1043–1047
  20. Hartwig JH. Platelet structure. In:  Michelson AD editors. Platelets. New York: Academic Press; 2002;p. 37–45
  21. Mitsakakis K, Lousinian S, Logothetidis S. Early stages of human plasma proteins adsorption probed by atomic force microscope. Biomol Eng. 2007;24:119–124
  22. Okpalugo TI, Ogwu AA, Maguire PD, McLaughlin JA. Platelet adhesion on silicon modified hydrogenated amorphous carbon films. Biomaterials. 2004;25:239–245
  23. Okpalugo T, Ogwu A, Maguire P, McLaughlin J, Hirst D. In-vitro blood compatibility of a-C:H:Si and a-C:H thin films. Diam Relat Mater. 2004;13:1088–1092
  24. Tsapikouni TS, Missirlis YF. pH and ionic strength effect on single fibrinogen molecule adsorption on mica studied with AFM. Colloids Surf B Biointerfaces. 2007;57:89–96
  25. Holmberg M, Stibius KM, Ndoni S, Larsen NB, Kingshott P, Hou XL. Protein aggregation and degradation during iodine labeling and its consequences for protein adsorption to biomaterials. Anal Biochem. 2007;361:120–125
  26. Noy A. Interactions at solid-fluid interfaces. In:  Liu X-Y,  De Yoreo JJ editor. Nanoscale structure and assembly at solid-fluid interfaces. vol I. Norwell, Massachusetts: Kluwer; 2004;p. 57–64
  27. Mandic R, Opper C, Krappe J, Wesemann W. Platelet sialic acid as a potential pathogenic factor in coronary heart disease. Thrombosis Res. 2002;106:137–141
  28. Seliger C, Schwennicke K, Schaffer C, Wolf WP, Alt E. Influence of a rough ceramic-like stent surface made of iridium oxide on neointimal structure and thickening. Eur Heart J. 2002;21(Suppl):282–290
  29. Palmaz JC, Benson A, Sprague EA. Influence of surface topography on endothelialisation of intravascular metallic stents. Mater J Vasc Interv Radiol. 1999;10:439–444
  30. Maguire PD, McLaughlin JA, Okpalugo TIT, Lemoine P, Papakonstantinou P, McAdams ET, et al. Mechanical stability, corrosion performance and bioresponse of amorphous diamond-like carbon for medical stents and guidewires. Diam Relat Mater. 2005;14:1277–1288
  31. Hasebe T, Ishimaru T, Kamijo A, Yoshimoto Y, Yoshimura T, Yohena S, et al. Effects of surface roughness on anti-thrombogenicity of diamond-like carbon films. Diam Relat Mater. 2007;16:1343–1348
  32. Lousinian S, Logothetidis S. Optical properties of proteins and protein adsorption study. Microelectron Eng. 2007;84:479–485
  33. Logothetidis S. Haemocompatibility of carbon based thin films. Diam Relat Mater. 2007;16:1847–1857
  34. Karagkiozaki V, Logothetidis S, Laskarakis A, Giannoglou G, Lousinian S. AFM study of the thrombogenicity of carbon-based coatings for cardiovascular applications. Mater Sci Eng B. 2008;[In press]
  35. Vijayanand K, Deepak K, Pattanayak D, Mohan R, Banerjee R. Interpreting blood-biomaterial interactions from surface free energy and work of adhesion. Trends Biomater Artif Organs. 2005;18:73–83

PII: S1549-9634(08)00120-2

doi: 10.1016/j.nano.2008.07.005

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 1 , Pages 64-72 , March 2009

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