Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 106-117 , June 2009

Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles

Received 7 May 2008 ,Accepted 13 August 2008.

References 

  1. Allen TM, Cullis PR. Drug delivery systems: entering the mainstream. Science. 2004;303:1818–1822
  2. Paciotti GF, Myer L, Weinreich D, Goia D, Pavel N, McLaughlin RE, et al. Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery. Drug Deliv. 2004;11:169–183
  3. Sonvico F, Mornet S, Vasseur S, Dubernet C, Jaillard D, Degrouard J, et al. Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: synthesis, physicochemical characterization, and in vitro experiments. Bioconjug Chem. 2005;16:1181–1188
  4. Moghimi SM, Hedeman H, Muir IS, Illum L, Davis SS. An investigation of the filtration capacity and the fate of large filtered sterically-stabilized microspheres in rat spleen. Biochim Biophys Acta. 1993;1157:233–240
  5. Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev. 2001;53:283–318
  6. Chithrani BD, Ghazani AA, Chan WC. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett. 2006;6:662–668
  7. Cedervall T, Lynch I, Foy M, Berggard T, Donnelly SC, Cagney G, et al. Detailed identification of plasma proteins adsorbed on copolymer nanoparticles. Angew Chem Int Ed Engl. 2007;46:5754–5756
  8. Cedervall T, Lynch I, Lindman S, Berggard T, Thulin E, Nilsson H, et al. Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proc Natl Acad Sci U S A. 2007;104:2050–2055
  9. Pergolese B, Bigotto A, Muniz-Miranda M, Sbrana G. Gold/palladium and silver/palladium colloids as novel metallic substrates for surface-enhanced Raman scattering. Appl Spectrosc. 2005;59:194–199
  10. Pergolese B, Muniz-Miranda M, Bigotto A. Surface enhanced Raman scattering investigation of the halide anion effect on the adsorption of 1,2,3-triazole on silver and gold colloidal nanoparticles. J Phys Chem B. 2005;109:9665–9671
  11. Powers KW, Brown SC, Krishna VB, Wasdo SC, Moudgil BM, Roberts SM. Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation. Toxicol Sci. 2006;90:296–303
  12. Murdock RC, Braydich-Stolle L, Schrand AM, Schlager JJ, Hussain SM. Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique. Toxicol Sci. 2008;101:239–253
  13. Kobayashi H, Kawamoto S, Jo SK, Bryant HL, Brechbiel MW, Star RA. Macromolecular MRI contrast agents with small dendrimers: pharmacokinetic differences between sizes and cores. Bioconjug Chem. 2003;14:388–394
  14. Luck M, Schroder W, Harnisch S, Thode K, Blunk T, Paulke BR, et al. Identification of plasma proteins facilitated by enrichment on particulate surfaces: analysis by two-dimensional electrophoresis and N-terminal microsequencing. Electrophoresis. 1997;18:2961–2967
  15. Diederichs JE. Plasma protein adsorption patterns on liposomes: establishment of analytical procedure. Electrophoresis. 1996;17:607–611
  16. Gessner A, Lieske A, Paulke BR, Muller RH. Influence of surface charge density on protein adsorption on polymeric nanoparticles: analysis by two-dimensional electrophoresis. Eur J Pharm Biopharm. 2002;54:165–170
  17. Gessner A, Lieske A, Paulke BR, Muller RH. Functional groups on polystyrene model nanoparticles: influence on protein adsorption. J Biomed Mater Res A. 2003;65:319–326
  18. Gessner A, Paulke BR, Muller RH, Goppert TM. Protein rejecting properties of PEG-grafted nanoparticles: influence of PEG-chain length and surface density evaluated by two-dimensional electrophoresis and bicinchoninic acid (BCA)-proteinassay. Pharmazie. 2006;61:293–297
  19. Peracchia MT, Harnisch S, Pinto-Alphandary H, Gulik A, Dedieu JC, Desmaele D, et al. Visualization of in vitro protein-rejecting properties of PEGylated stealth (R) polycyanoacrylate nanoparticles. Biomaterials. 1999;20:1269–1275
  20. Gref R, Luck M, Quellec P, Marchand M, Dellacherie E, Harnisch S, et al. ‘Stealth’ corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf B Biointerfaces. 2000;18:301–313
  21. Salvador-Morales C, Flahaut E, Sim E, Sloan J, Green ML, Sim RB. Complement activation and protein adsorption by carbon nanotubes. Mol Immunol. 2006;43:193–201
  22. Schaller J, Gerber S, Kampfer U, Lejon S, Trachsel C. Human blood proteins: structure and function. New York: Wiley; 2008;
  23. Lynch T, Cedervall M, Lundqvist C, Cabaleiro-Lago S, Linse S, Dawson KA. The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century. Adv Colloid Interface Sci. 2007;134-135:167–174

 The study was supported in whole or in part by federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400.

 The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government.

PII: S1549-9634(08)00144-5

doi: 10.1016/j.nano.2008.08.001

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 106-117 , June 2009