Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 170-177, June 2009

Cortisol controlled release by mesoporous silica

  • Tessy Lopez, PhD

      Affiliations

    • Departamento Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, Tlalpan, México DF, México
    • Instituto Nacional de Neurología y Neurocirugía “MVS”, México DF, México
    • Corresponding Author InformationCorresponding author. National Institute of Neurology and Neurosurgery, Nanotechnology, Parque Palacio 2, Colonia El Parque de Coyoacan Del., México D.F., México 04899, Mexico.
    • ,
  • Emma Ortiz, PhD

      Affiliations

    • Instituto Nacional de Neurología y Neurocirugía “MVS”, México DF, México
    • ,
  • Roberto Alexander-Katz, PhD

      Affiliations

    • Departamento de Física, Universidad Autónoma Metropolitana-Iztapalapa, México DF, México
    • ,
  • Elena Basaldella, PhD

      Affiliations

    • CIC-CINDECA–Universidad Nacional de La Plata, La Plata, Argentina
    • ,
  • Xim Bokhimi, PhD

      Affiliations

    • Instituto de Física de la Universidad Nacional Autónoma de México, Circuito de la Investigación s/n, Ciudad Universitaria, México DF, México

Received 17 December 2007; accepted 14 August 2008. published online 17 December 2008.

Abstract 

In this study four types of SBAs were synthesized and then impregnated with hydrocortisone. One is a straight SBA-15, obtained using Pluronics P123 as structuring agent; two others were modified using 1,3,5-trimethylbenzene as additive, and the fourth one was prepared using sodium iodide as additive. Three of these have in common a p6mm symmetry with nanotubes packed hexagonally, yet they differ in their functional groups. The fourth sample is basically disordered. The drug release kinetics showed two stages: a fast-rate early stage dominated by the controlled release of the hydrocortisone adsorbed in the macropores of the reservoir, followed by a slow-rate delivery that we assume is controlled by the hydrocortisone diffusion through the nanopores. It is shown that the release kinetics can be strongly influenced by using different co-additives.

Key words: Hydrocortisone, Mesoporous, Ordered silicas, Drug release, Sol-gel

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 Sources of support for this research: Universidad Autonoma Metropolitana (México), Instituto Nacional de Neurología y Neurocirugía “MVS” (México), and CYTED program (Spain).

PII: S1549-9634(08)00145-7

doi:10.1016/j.nano.2008.08.002

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 170-177, June 2009

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