Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 216-224 , June 2009

Quantum dots encapsulated in phospholipid micelles for imaging and quantification of tumors in the near-infrared region

Received 8 July 2008 ,Accepted 14 October 2008.

References 

  1. Rao J, Dragulescu-Andrasi A, Yao H. Fluorescence imaging in vivo: recent advances. Curr Opin Biotechnol. 2007;18:17–25
  2. Frangioni JV. In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol. 2003;7:626–634
  3. Adams KE, Ke S, Kwon S, Liang F, Lu Y, et al. Comparison of visible and near-infrared wavelength-excitable fluorescent dyes for molecular imaging of cancer. J Biomed Opt. 2007;12:024017
  4. Backer MV, Levashova Z, Patel V, Jehning BT, Claffey K, Blankenberg FG, et al. Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes. Nat Med. 2007;13:504–509
  5. Ke S, Wen X, Gurfinkel M, Charnsangavej C, Wallace S, Sevick-Muraca EM, et al. Near-infrared optical imaging of epidermal growth factor receptor in breast cancer xenografts. Cancer Res. 2003;63:7870–7875
  6. Kim S, Lim YT, Soltesz EG, De Grand AM, Lee J, Nakayama A, et al. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol. 2004;22:93–97
  7. Medarova Z, Pham W, Kim Y, Dai G, Moore A. In vivo imaging of tumor response to therapy using a dual-modality imaging strategy. Int J Cancer. 2006;118:2796–2802
  8. Bogdanov AA, Lin CP, Kang HW. Optical imaging of the adoptive transfer of human endothelial cells in mice using anti-human CD31 monoclonal antibody. Pharm Res. 2007;24:1186–1192
  9. Christian NA, Milone MC, Ranka SS, Li G, Frail PR, Davis KP, et al. Tat-functionalized near-infrared emissive polymersomes for dendritic cell labeling. Bioconjug Chem. 2007;18:31–40
  10. Cai W, Shin DW, Chen K, Gheysens O, Cao Q, Wang SX, et al. Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Lett. 2006;6:669–676
  11. van Tilborg GA, Mulder WJ, Chin PT, Storm G, Reutelingsperger CP, Nicolay K, et al. Annexin A5-conjugated quantum dots with a paramagnetic lipidic coating for the multimodal detection of apoptotic cells. Bioconjug Chem. 2006;17:865–868
  12. Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science. 2005;307:538–544
  13. Mulder WJ, Koole R, Brandwijk RJ, Storm G, Chin PT, Strijkers GJ, et al. Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe. Nano Lett. 2006;6:1–6
  14. Alivisatos AP, Gu W, Larabell C. Quantum dots as cellular probes. Annu Rev Biomed Eng. 2005;7:55–76
  15. Gao X, Yang L, Petros JA, Marshall FF, Simons JW, Nie S. In vivo molecular and cellular imaging with quantum dots. Curr Opin Biotechnol. 2005;16:63–72
  16. Gao X, Cui Y, Levenson RM, Chung LW, Nie S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol. 2004;228:969–976
  17. Cai W, Chen K, Li ZB, Gambhir SS, Chen X. Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature. J Nucl Med. 2007;48:1862–1870
  18. Jiang W, Papa E, Fischer H, Mardyani S, Chan WC. Semiconductor quantum dots as contrast agents for whole animal imaging. Trends Biotechnol. 2004;22:607–609
  19. Chalmers NI, Palmer RJ, Du-Thumm L, Sullivan R, Shi W, Kolenbrander PE. Use of quantum dot luminescent probes to achieve single-cell resolution of human oral bacteria in biofilms. Appl Environ Microbiol. 2007;73:630–636
  20. Pinaud F, Michalet X, Bentolila LA, Tsay JM, Doose S, Li JJ, et al. Advances in fluorescence imaging with quantum dot bio-probes. Biomaterials. 2006;27:1679–1687
  21. Buhro WE, Colvin VL. Semiconductor nanocrystals: shape matters. Nat Mater. 2003;2:138–139
  22. Hoshino A, Manabe N, Fujioka K, Suzuki K, Yasuhara M, Yamamoto K. Use of fluorescent quantum dot bioconjugates for cellular imaging of immune cells, cell organelle labeling, and nanomedicine: surface modification regulates biological function, including cytotoxicity. J Artif Organs. 2007;10:149–157
  23. Ballou B, Lagerholm BC, Ernst LA, Bruchez MP, Waggoner AS. Noninvasive imaging of quantum dots in mice. Bioconjug Chem. 2004;15:79–86
  24. Slocik JM, Tam F, Halas NJ, Naik RR. Peptide-assembled optically responsive nanoparticle complexes. Nano Lett. 2007;7:1054–1058
  25. Torchilin VP. Micellar nanocarriers: pharmaceutical perspectives. Pharm Res. 2007;24:1–16
  26. Torchilin VP. Targeted pharmaceutical nanocarriers for cancer therapy and imaging. AAPS JPharmSciTech. 2007;9:E128–E147
  27. Roby A, Erdogan S, Torchilin VP. Enhanced in vivo antitumor efficacy of poorly soluble PDT agent, meso-tetraphenylporphine, in PEG-PE-based tumor-targeted immunomicelles. Cancer Biol Ther. 2007;6:[Epub ahead of print.]
  28. Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, et al. Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nat Med. 2005;11:678–682
  29. Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A. In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science. 2002;298:1759–1762
  30. Ntziachristos V, Turner G, Dunham J, Windsor S, Soubret A, Ripoll J, et al. Planar fluorescence imaging using normalized data. J Biomed Opt. 2005;10:064007-1–064007-8
  31. Ntziachristos V. Fluorescence molecular imaging. Annu Rev Biomed Eng. 2006;8:1–33
  32. National Research Council . Guide for the Care and Use of Laboratory Animals. DHHS Publication No. Department of Health and Human Services, NRC, Committee on Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources. 1985;
  33. Gao M, Lewis G, Turner GM, Soubret A, Ntziachristos V. Effects of background fluorescence in fluorescence molecular tomography. Appl Opt. 2005;44:5468–5474
  34. Soubret A, Ntziachristos V. Fluorescence molecular tomography in the presence of background fluorescence. Phys Med Biol. 2006;51:3983–4001
  35. Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanor A, et al. Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V–Cy5.5 conjugate. Proc Natl Acad Sci U S A. 2004;101:12294–12299
  36. Chen H, Wang Y, Xu J, Ji J, Zhang J, Hu Y, et al. Non-invasive near infrared fluorescence imaging of CdHgTe quantum dots in mouse model. J Fluorescence. 2008;18:801–811
  37. Hama Y, Koyama Y, Urano Y, Choyke PL, Kobayashi H. Two-color lymphatic mapping using Ig-conjugated near infrared optical probes. J Invest Dermatol. 2007;127:2351–2356
  38. Hama Y, Koyama Y, Urano Y, Choyke PL, Kobayashi H. Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity. Breast Cancer Res Treat. 2007;103:23–28
  39. Yang RS, Chang LW, Wu JP, Tsai MH, Wang HJ, Kuo YC, et al. Persistent tissue kinetics and redistribution of nanoparticles, quantum dot 705, in mice: ICP-MS quantitative assessment. Environ Health Perspect. 2007;115:1339–1343
  40. Cho SJ, Maysinger D, Jain M, Roder B, Hackbarth S, Winnik FM. Long-term exposure to CdTe quantum dots causes functional impairments in live cells. Langmuir. 2007;23:1974–1980
  41. Maysinger D, Behrendt M, Lalancette-Hebert M, Kriz J. Real-time imaging of astrocyte response to quantum dots: in vivo screening model system for biocompatibility of nanoparticles. Nano Lett. 2007;7:2513–2520
  42. Shiohara A, Hoshino A, Hanaki K, Suzuki K, Yamamoto K. On the cyto-toxicity caused by quantum dots. Microbiol Immunol. 2004;48:669–675

 This work was supported by National Institutes of Health grant RO1 EB001961 to V.P. Torchilin.

PII: S1549-9634(08)00181-0

doi: 10.1016/j.nano.2008.10.001

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 216-224 , June 2009

Article Tools

* Image Usage & Resolution