Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 225-231, June 2009

Protection from radiation-induced pneumonitis using cerium oxide nanoparticles

  • Jimmie Colon, MS

      Affiliations

    • Cancer Research Institute, M.D. Anderson Cancer Center Orlando, Orlando, Florida, USA
    • ,
  • Luis Herrera, MD

      Affiliations

    • Department of Thoracic Surgery, M.D. Anderson Cancer Center Orlando, Orlando, Florida, USA
    • ,
  • Joshua Smith, BS

      Affiliations

    • Cancer Research Institute, M.D. Anderson Cancer Center Orlando, Orlando, Florida, USA
    • ,
  • Swanand Patil, PhD

      Affiliations

    • Department of Mechanical, Materials and Aerospace Engineering, Advanced Materials Processing and Analysis Center (AMPAC), University of Central Florida, Orlando, Florida, USA
    • ,
  • Chris Komanski, BS

      Affiliations

    • Cancer Research Institute, M.D. Anderson Cancer Center Orlando, Orlando, Florida, USA
    • ,
  • Patrick Kupelian, MD

      Affiliations

    • Department of Radiation Oncology, M.D. Anderson Cancer Center Orlando, Orlando, Florida, USA
    • ,
  • Sudipta Seal, PhD

      Affiliations

    • Department of Mechanical, Materials and Aerospace Engineering, Advanced Materials Processing and Analysis Center (AMPAC), University of Central Florida, Orlando, Florida, USA
    • Nanoscience and Technology Center, University of Central Florida, Orlando, Florida, USA
    • ,
  • D. Wayne Jenkins, MD

      Affiliations

    • Department of Radiation Oncology, M.D. Anderson Cancer Center Orlando, Orlando, Florida, USA
    • ,
  • Cheryl H. Baker, PhD

      Affiliations

    • Cancer Research Institute, M.D. Anderson Cancer Center Orlando, Orlando, Florida, USA
    • Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA
    • Corresponding Author InformationCorresponding author. Cancer Research Institute, M.D. Anderson Cancer Center, Orlando, 110 Bonnie Loch Court, Orlando, FL 32806, USA.

Received 24 July 2008; accepted 4 October 2008. published online 06 November 2008.

Abstract 

In an effort to combat the harmful effects of radiation exposure, we propose that rare-earth cerium oxide (CeO2) nanoparticles (free-radical scavengers) protect normal tissue from radiation-induced damage. Preliminary studies suggest that these nanoparticles may be a therapeutic regenerative nanomedicine that will scavenge reactive oxygen species, which are responsible for radiation-induced cell damage. The effectiveness of CeO2 nanoparticles in radiation protection in murine models during high-dose radiation exposure is investigated, with the ultimate goal of offering a new approach to radiation protection, using nanotechnology. We show that CeO2 nanoparticles are well tolerated by live animals, and they prevent the onset of radiation-induced pneumonitis when delivered to live animals exposed to high doses of radiation. In the end, these studies provide a tremendous potential for radioprotection and can lead to significant benefits for the preservation of human health and the quality of life for humans receiving radiation therapy.

Key words: Radioprotection, Nanoparticles, Pneumonitis, Quality of life

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 This collaboration was made possible through the support of the M.D. Anderson Cancer Center Orlando, University of Central Florida, and the National Science Foundation and the CCMI.

PII: S1549-9634(08)00183-4

doi:10.1016/j.nano.2008.10.003

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 225-231, June 2009

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