Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 162-169 , June 2009

Protracted elimination of gold nanoparticles from mouse liver

  • Evaldas Sadauskas, MD

      Affiliations

    • Department of Neurobiology, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark
    • National Research Centre for the Working Environment, Copenhagen, Denmark
    • Corresponding Author InformationCorresponding author. Department of Neurobiology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark.
  • ,
  • Gorm Danscher, DVM, DMSc

      Affiliations

    • Department of Neurobiology, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark
  • ,
  • Meredin Stoltenberg, MD, PhD, DMSc

      Affiliations

    • Department of Neurobiology, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark
  • ,
  • Ulla Vogel, PhD

      Affiliations

    • National Research Centre for the Working Environment, Copenhagen, Denmark
    • National Food Institute, Technical University of Denmark, Søborg, Denmark
    • Institute for Science, Systems and Models, University of Roskilde, Roskilde, Denmark
  • ,
  • Agnete Larsen, MD, PhD

      Affiliations

    • Department of Neurobiology, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark
  • ,
  • Håkan Wallin, PhD

      Affiliations

    • National Research Centre for the Working Environment, Copenhagen, Denmark

Received 24 July 2008 ,Accepted 9 November 2008.

References 

  1. Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles [review]. Environ Health Perspect. 2005;113:823–839
  2. Donaldson K. Resolving the nanoparticles paradox [review]. Nanomedicine. 2006;1:229–234
  3. Nemmar A, Hoylaerts MF, Hoet PH, Nemery B. Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects. Toxicol Lett. 2004;9:243–253
  4. Kreyling WG, Semmler-Behnke M, Möller W. Ultrafine particle-lung interactions: does size matter [review]?. J Aerosol Med. 2006;19:74–83
  5. Borm PJ, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, et al. The potential risks of nanomaterials: a review carried out for ECETOC. Part Fibre Toxicol. 2006;3:11
  6. Singer JM, Adlersberg L, Sadek M. Long-term observation of intravenously injected colloidal gold in mice [no abstract available]. J Reticuloendothel Soc. 1972;12:658–671
  7. McEntee MF, Ficken MD. Blood clearance of radiolabeled gold colloid by the turkey mononuclear phagocytic system. Avian Dis. 1990;34:393–397
  8. Rømert P, Quistorff B, Bhenke O. Histological evaluation of the zonation of colloidal gold uptake by the rat liver. Tissue Cell. 1993;25:19–32
  9. Sadauskas E, Wallin H, Stoltenberg M, Vogel U, Doering P, Larsen A, et al. Kupffer cells are central in the removal of nanoparticles from the organism. Part Fibre Toxicol. 2007;4:10
  10. Bouwens L, Baekeland M, Wisse E. Cytokinetic analysis of the expanding Kupffer-cell population in rat liver. Cell Tissue Kinet. 1986;19:217–226
  11. Freitas RA. Nanomedicine, Volume IIA: Biocompatibility. http://www.nanomedicine.com/NMIIA/15.4.3.2.3.htm2003;
  12. Danscher G, Stoltenberg M. Silver enhancement of quantum dots resulting from (1) metabolism of toxic metals in animals and humans, (2) in vivo, in vitro and immersion created zinc-sulphur/zinc-selenium nanocrystals, (3) metal ions liberated from metal implants and particles [review]. Prog Histochem Cytochem. 2006;41:57–139
  13. Danscher G, Norgaard JO. Light microscopic visualization of colloidal gold on resin-embedded tissue. J Histochem Cytochem. 1983;31:1394–1398
  14. Hainfeld JF, Slatkin DN, Focella TM, Smilowitz HM. Gold nanoparticles: a new X-ray contrast agent. Br J Radiol. 2006;79:248–253
  15. Jain PK, Huang X, El-Sayed IH, El-Sayed MA. Noble metals on the nanoscale: optical and photothermal properties and some applications in imaging, sensing, biology, and medicine. Acc Chem Res. 2008;[Electronic publication ahead of print]
  16. Bergen JM, von Recum HA, Goodman TT, Massey AP, Pun SH. Gold nanoparticles as a versatile platform for optimizing physicochemical parameters for targeted drug delivery. Macromol Biosci. 2006;6:506–516
  17. Danscher G. Localization of gold in biological tissue. A photochemical method for light and electron microscopy. Histochemistry. 1981;71:81–88
  18. Engström E, RodushKin I, Baxter DC, Ohlander B. Chromatographic purification for the determination of dissolved silicon isotopic compositions in natural waters by high-resolution multicollector inductively coupled plasma mass spectrometry. Anal Chem. 2006;78:250–257
  19. Krasinskas AM, Minda J, Saul SH, Shaked A, Furth EE. Redistribution of thorotrast into a liver allograft several years following transplantation: a case report. Mod Pathol. 2004;17:117
  20. Wegener K, Wesch H, Kampmann H. Investigations into human thorotrastosis. Tissue concentrations of 232-Th and late effects in 13 autopsy cases. Virchows Arch A Pathol Anat Histol. 1976;371:131–143
  21. Odegaard A, Ophus EM, Larsen AM. Identification of thorium dioxide in human liver cells by electron microscopic x-ray microanalysis. J Clin Pathol. 1978;31:893–896
  22. Kim D, Park S, Lee JH, Jeong YY, Jon S. Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging. J Am Chem Soc. 2007;129:7661–7665[Electronic publication 2007 May 27. Erratum in: J Am Chem Soc. 2007;129:12585]
  23. Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: theory to practice [review]. Pharmacol Rev. 2001;53:283–318
  24. Fujita H, Kawamata S, Yamashita K. Electron microscopic studies on multinucleate foreign body giant cells derived from Kupffer cells in mice given India ink intravenously. Virchows Arch B Cell Pathol Incl Mol Pathol. 1983;42:33–42
  25. Yamashita K, Fujita H, Kawamata S. Fine structural and cytochemical aspects of granuloma formation derived from Kupffer cells in mice injected with latex particles. Arch Histol Jpn. 1985;48:315–326
  26. Geneser F. In: Textbook of histology. Philadelphia, PA: Lea & Febiger; 1986;p. 532–548
  27. Parker GA, Picut CA. Liver immunobiology [review]. Toxicol Pathol. 2005;33:52–62
  28. Sleyster EC, Knook DL. Relation between localization and function of rat liver Kupffer cells. Lab Invest. 1982;47:484–490
  29. Shiratori Y, Tananka M, Kawase T, Shiina S, Komatsu Y, Omata M. Quantification of sinusoidal cell function in vivo. Semin Liver Dis. 1993;13:39–49
  30. Zhang ZR, He Q. Study on liver targeting and hepatocytes permeable valaciclovir polybutylcyanoacrylate nanoparticles. World J Gastroenterol. 1999;5:330–333
  31. Lin A, Liu Y, Huang Y, Sun J, Wu Z, Zhang X, et al. Glycyrrhizin surface-modified chitosan nanoparticles for hepatocyte-targeted delivery. Int J Pharm. 2008;359:247–253
  32. Ogura T, Takaoka M, Yamauchi T, Oishi T, Mimura Y, Hashimoto M, et al. Changes in urinary enzyme activity and histochemical findings in experimental tubular injury induced by gold sodium thiomalate. J Med. 1996;27:41–55
  33. Holgate CS, Jackson P, Cowen PN, Bird CC. Immunogold-silver staining: new method of immunostaining with enhanced sensitivity. J Histochem Cytochem. 1983;31:938–944
  34. Penn SG, He L, Natan MJ. Nanoparticles for bioanalysis [review]. Curr Opin Chem Biol. 2003;7:609–615
  35. Stoltenberg M, Larsen A, Doering P, Sadauskas E, Locht LJ, Danscher G. Autometallographic tracing of quantum dots. Histol Histopathol. 2007;22:617–622
  36. Shukla R, Bansal V, Chaudhary M, Basu A, Bhonde RR, Sastry M. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir. 2005;21:10644–10654
  37. Adlersberg L, Singer JM. The fate of intraperitoneally injected colloidal gold particles in mice [no abstract available]. J Reticuloendothel Soc. 1973;13:325–342
  38. Haraldsson B, Sorensson J. Why do we not all have proteinuria? An update of our current understanding of the glomerular barrier [review]. News Physiol Sci. 2004;19:7–10
  39. Tencer J, Frick IM, Oquist BW, Alm P, Rippe B. Size-selectivity of the glomerular barrier to high molecular weight proteins: upper size limitations of shunt pathways. Kidney Int. 1998;53:709–715
  40. De Jong WH, Hagens WI, Krystek P, Burger MC, Sips AJ, Geertsma RE. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials. 2008;29:1912–1919

 This work was supported by grants from the Danish Ministry of Interior and Health, Research Centre for Environmental Health's Fund, The Danish Medical Research Council, Aarhus University, and The National Research Centre for the Working Environment NRCWE and the Danielsen foundation.

PII: S1549-9634(08)00188-3

doi: 10.1016/j.nano.2008.11.002

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 162-169 , June 2009