Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 3 , Pages 345-351 , September 2009

Self-assembling peptide nanofiber scaffold promotes the reconstruction of acutely injured brain

  • Jiasong Guo, PhD

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • Department of Histology and Embryology, Southern Medical University, Guangzhou, China
    • These authors contributed equally to this work.
    • ,
  • Ka Kit Gilberto Leung, MD

      Affiliations

    • Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • These authors contributed equally to this work.
    • ,
  • Huanxing Su, PhD

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • ,
  • Qiuju Yuan, PhD

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • ,
  • Li Wang, PhD

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • ,
  • Tak-Ho Chu, PhD

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • ,
  • Wenming Zhang, MD

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • ,
  • Jenny Kan Suen Pu, MD

      Affiliations

    • Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • ,
  • Gloria Kowk Po Ng, BSc

      Affiliations

    • Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • ,
  • Wai Man Wong, MS

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • ,
  • Xiang Dai, MD

      Affiliations

    • Department of Histology and Embryology, Southern Medical University, Guangzhou, China
    • ,
  • Wutian Wu, MD, PhD

      Affiliations

    • Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • State Key Laboratory for Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • Research Center of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    • Corresponding Author InformationCorresponding author. Department of Anatomy, University of Hong Kong Li Ka Shing Faculty of Medicine, Pokfulam, Hong Kong SAR, China.

Received 3 June 2008 ,Accepted 6 December 2008.

References 

  1. Werner C, Engelhard K. Pathophysiology of traumatic brain injury. Br J Anaesth. 2007;99:4–9
  2. Oehmichen M, Meissner C, König HG. Brain injury after gunshot wounding: morphometric analysis of cell destruction caused by temporary cavitation. J Neurotrauma. 2000;17:155–162
  3. Fitch MT, Silver J. Activated macrophages and the blood-brain barrier: inflammation after CNS injury leads to increases in putative inhibitory molecules. Exp Neurol. 1997;148:587–603
  4. Zhang H, Hayashi T, Tsuru K, Deguchi K, Nagahara M, Hayakawa S, et al. Vascular endothelial growth factor promotes brain tissue regeneration with a novel biomaterial polydimethylsiloxane-tetraethoxysilane. Brain Res. 2007;1132:29–35
  5. Wang H, Lynch JR, Song P, Yang HJ, Yates RB, Mace B, et al. Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol. 2007;206:59–69
  6. Tenovuo O. Pharmacological enhancement of cognitive and behavioral deficits after traumatic brain injury. Curr Opin Neurol. 2006;19:528–533
  7. Crooks CY. Traumatic brain injury: the importance of rehabilitation and treatment. Mol Med. 2008;105:140–144
  8. Tisdall MM, Smith M. Multimodal monitoring in traumatic brain injury: current status and future directions. Br J Anaesth. 2007;99:61–67
  9. Lu D, Mahmood A, Qu C, Hong X, Kaplan D, Chopp M. Collagen scaffolds populated with human marrow stromal cells reduce lesion volume and improve functional outcome after traumatic brain injury. Neurosurgery. 2007;61:596–603
  10. Cui FZ, Tian WM, Hou SP, Xu QY, Lee IS. Hyaluronic acid hydrogel immobilized with RGD peptides for brain tissue engineering. J Mater Sci Mater Med. 2006;17:1393–1401
  11. Wong DY, Hollister SJ, Krebsbach PH, Nosrat C. Poly(epsilon-caprolactone) and poly(l-lactic-co-glycolic acid) degradable polymer sponges attenuate astrocyte response and lesion growth in acute traumatic brain injury. Tissue Eng. 2007;13:2515–2523
  12. Guo J, Su H, Zeng Y, Liang YX, Wong WM, Ellis-Behnke RG, et al. Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold. Nanomedicine. 2007;3:311–321
  13. Ellis-Behnke R, Liang Y, You S, Tay D, Zhang S, So K, et al. Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc Natl Acad Sci USA. 2006;103:5054–5059
  14. Holmes T. Novel peptide-based biomaterial scaffolds for tissue engineering. Trends Biotechnol. 2002;20:16–21
  15. Zhang S. Designer self-assembling peptide nanofiber scaffolds for study of 3D cell biology and beyond. Adv Cancer Res. 2008;99:335–362
  16. Davis ME, Hsieh PC, Takahashi T, Song Q, Zhang S, Kamm RD, et al. Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci USA. 2006;103:8155–8160
  17. Holmes TC, de Lacalle S, Su X, Liu G, Rich A, Zhang S. Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proc Natl Acad Sci USA. 2000;97:6728–6733
  18. Ellis-Behnke RG, Liang YX, Tay DK, Kau PW, Schneider GE, Zhang S, et al. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine. 2006;2:207–215
  19. Dash PK, Moore AN, Moody MR, Treadwell R, Felix JL, Clifton GL. Post-trauma administration of caffeine plus ethanol reduces contusion volume and improves working memory in rats. J Neurotrauma. 2004;21:1573–1583
  20. Castillo-Ruiz MM, Campuzano O, Acarin L, Castellano B, Gonzalez B. Delayed neurodegeneration and early astrogliosis after excitotoxicity to the aged brain. Exp Gerontol. 2007;42:343–354
  21. Willerth SM, Sakiyama-Elbert SE. Approaches to neural tissue engineering using scaffolds for drug delivery. Adv Drug Deliv Rev. 2007;59:325–338
  22. Wang S, Nagrath D, Chen PC, Berthiaume F, Yarmush ML. Three-dimensional primary hepatocyte culture in synthetic self-assembling peptide hydrogel. Tissue Eng A. 2008;14:227–236
  23. Navarro-Alvarez N, Soto-Gutierrez A, Rivas-Carrillo JD, Chen Y, Yamamoto T, Yuasa T, et al. Self-assembling peptide nanofiber as a novel culture system for isolated porcine hepatocytes. Cell Transplant. 2006;15:921–927
  24. Deguchi K, Tsuru K, Hayashi T, Takaishi M, Nagahara M, Nagotani S, et al. Implantation of a new porous gelatin-siloxane hybrid into a brain lesion as a potential scaffold for tissue regeneration. J Cereb Blood Flow Metab. 2006;26:1263–1273

 Financial support was provided by the University of Hong Kong and Hong Kong Research Grants Council.

PII: S1549-9634(08)00190-1

doi: 10.1016/j.nano.2008.12.001

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 3 , Pages 345-351 , September 2009

Article Tools

* Image Usage & Resolution