Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 3 , Pages 274-281 , September 2009

Formation of simvastatin nanoparticles from microemulsion

Received 24 August 2008 ,Accepted 20 November 2008.

References 

  1. Bushrab FN, Muller RH. Nanocrystals of poorly soluble drugs for oral administration. New Drugs Online. 2003;5:20–22
  2. Noyes AA, Whitney WR. The rate of solution of solid substances in their own solutions. J Am Chem Soc. 1897;19:930–934
  3. Das NG, Das SK. Formulation of poorly soluble drugs. Drug Deliv Rep. 2006;Spring/Summer:52-5
  4. Merisko-Liversidge E, Liversidge GG, Cooper ER. Nanosizing: a formulation approach for poorly-water-soluble compounds. Eur J Pharm Sci. 2003;18:113–120
  5. Matteucci ME, Brettman BK, Rogers RL, Elder EJ, Williams RO, Johnston KP. Design of potent amorphous drug nanoparticles for rapid generation of highly supersaturated media. Mol Pharm. 2007;4:782–793
  6. Chen JF, Zhang JY, Shen ZG, Zhong J, Yun J. Preparation and characterization of amorphous Cefuroxime Axetil drug nanoparticles with novel technology: high-gravity antisolvent precipitation. Ind Eng Chem Res. 2006;45:8723–8727
  7. Matteucci ME. Drug nanoparticles by antisolvent precipitation: mixing energy versus surfactant stabilization. Langmuir. 2006;22:8951–8959
  8. Rogers TL, Gillespie IB, Hitt JE, Fransen KL, Crowl CA, Tucker CJ, et al. Development and characterization of a scalable controlled precipitation process to enhance the dissolution of poorly water-soluble drugs. Pharm Res. 2004;21:2048–2057
  9. Chen X, Young TJ, Sarkari M, Williams RO, Johnston KP. Preparation of cyclosporine A nanoparticles by evaporative precipitation into aqueous solution. Int J Pharm. 2002;242:3–14
  10. Türk M, Hils P, Helfgen B, Schaber K, Martin HJ, Wahl MA. Micronization of pharmaceutical substances by the rapid expansion of supercritical solutions (RESS): a promising method to improve bioavailability of poorly soluble pharmaceutical agents. J Supercritical Fluids. 2002;22:75–84
  11. Perrut M, Jung J, Leboeuf F. Enhancement of dissolution rate of poorly-soluble active ingredients by supercritical fluid processes Part I: Micronization of neat particles. Int J Pharm. 2005;288:3–10
  12. Hu J, Johnson KP, Williams RO. Rapid dissolving high potency danazol powders produced by spray freezing into liquid process. Int J Pharm. 2004;271:145–154
  13. Kamishny A, Magdassi S. Nanoparticles in confined structures: formation and application. In:  Tadros TH editors. Colloid stability: the role of surface forces, Part 1. Weinheim: Wiley-VCH; 2007;p. 207–234
  14. Desgouilles S, Vauthier C, Bazile D, Vacus J, Grossiord JL, Veillard M, et al. The design of nanoparticles obtained by solvent evaporation: a comprehensive study. Langmuir. 2003;19:9504–9510
  15. Shekunov BY, Chattopadhyay P, Seitzinger J, Huff R. Nanoparticles of poorly water-soluble drugs prepared by supercritical fluid extraction of emulsions. Pharm Res. 2006;23:196–204
  16. Magdassi S, Nativi H, Margulis-Goshen K. Organic nanoparticles obtained from microemulsions by solvent evaporation. International Patent Application No.: PCT/IL2007/001136.
  17. Debuigne F, Jeunieau L, Wiame M, Nagy JB. Synthesis of organic nanoparticles in different w/o microemulsions. Langmuir. 2000;16:7605–7611
  18. Destrée C, Ghijsen J, Nagy JB. Preparation of organic nanoparticles using microemulsions: their potential use in transdermal delivery. Langmuir. 2007;23:1965–1973
  19. Destrée C, Nagy JB. Mechanism of formation of inorganic and organic nanoparticles from microemulsions. Adv Colloid Interface Sci. 2006;123-126:353–367
  20. Trotta M, Gallarate M, Carlotti ME, Morel S. Preparation of griseofulvin nanoparticles from water-dilutable microemulsions. Int J Pharm. 2003;254:235–242
  21. Carlucci G, Mazzeo P, Biordi L, Bologna M. Simultaneous determination of simvastatin and its hydroxy acid form in human plasma by high-performance liquid chromatography with UV detection. J Pharm Biomed Anal. 1992;10:693–697
  22. O'Neil MJ. In: The Merck index—an encyclopedia of chemicals, drugs and biologicals. 14th ed.. Whitehouse Station, NJ: Merck & Co., Inc.; 2006;p. 1471–1472
  23. Patel RP, Patel MM. Inclusion complexion—physico-chemical characterization and in vitro dissolution behavior of simvastatin-cyclodextrin inclusion compounds. Drug Deliv Technol. 2007;7:50–56
  24. Pflaum A, Salobir M, Jerala Z, Resman A. Solid pharmaceutical formulation containing lovastatin and simvastatin respectively, and its preparation. United States patent US 6984399.
  25. Kang BK, Lee JS, Chon SKL, Jeong SY, Yuk SH, Khang G, et al. Development of self-microemulsifying drug delivery systems (SMEDDs) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm. 2004;274:65–73
  26. Ambike AA, Mahadik KR, Paradkar A. Spray-dried amorphous solid dispersions of simvastatin, a low Tg drug, in vitro and in vivo evaluations. Pharm Res. 2005;22:990–998
  27. Yang DJ, Hwang LS. Study on the conversion of three natural statins from lactone forms to their corresponding hydroxy acid forms and their determination in Pu-Erh tea. J Chromatogr A. 2006;1119:277–284
  28. Álvarez-Lueje A, Valenzuela C, Squella JA, Núńez-Vergara LJ. Stability study of simvastatin under hydrolytic conditions assessed by liquid chromatography. J AOAC Int. 2005;88:1631–1636

PII: S1549-9634(08)00191-3

doi: 10.1016/j.nano.2008.11.004

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 3 , Pages 274-281 , September 2009

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