Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 128-135, June 2009

Biodistribution of maltose and gum arabic hybrid gold nanoparticles after intravenous injection in juvenile swine

  • Genevieve M. Fent, DVM

      Affiliations

    • Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA
    • Corresponding Author InformationCorresponding author. Veterinary Medical Diagnostic Laboratory, University of Missouri, Columbia, Missouri, USA.
    • ,
  • Stan W. Casteel, DVM, PhD

      Affiliations

    • Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA
    • ,
  • Dae Young Kim, DVM, PhD

      Affiliations

    • Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA
    • ,
  • Raghuraman Kannan, MS, PhD

      Affiliations

    • Department of Radiology, University of Missouri, Columbia, Missouri, USA
    • ,
  • Kavita Katti, BS

      Affiliations

    • Department of Radiology, University of Missouri, Columbia, Missouri, USA
    • ,
  • Nripen Chanda, PhD

      Affiliations

    • Department of Radiology, University of Missouri, Columbia, Missouri, USA
    • ,
  • Kattesh Katti, MScED, PhD

      Affiliations

    • Department of Radiology, University of Missouri, Columbia, Missouri, USA

Received 12 June 2008; accepted 13 January 2009. published online 17 February 2009.

Abstract 

This article describes several experiments performed to test our hypothesis that the agent used to coat/stabilize gold nanoparticles (AuNPs) will act to direct the AuNPs to specific tissues within the body and that changing the coating will change the target organ. Samples were also collected for pathological examination. Gum arabic– (GA) and maltose- (MALT) stabilized AuNPs were administered intravenously to juvenile swine, and blood, tissue, and urine samples were collected for gold analysis. Our results indicate that differences do exist between the two NP constructs tested, with 50% or greater of the total gold dose being found in the liver or lung for the GA- and MALT-stabilized AuNPs, respectively. These findings indicate that the functional unit used to coat/stabilize the AuNPs has an important role in determining the tissue distribution profile for individual AuNP constructs.

Key words: Gold, Nanoparticle, Biodistribution, Swine

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 This work has been supported by the National Institutes of Health/National Cancer Institute under the Cancer Nanotechnology Program (grant no. 5R01CA119412-01).

PII: S1549-9634(09)00045-8

doi:10.1016/j.nano.2009.01.007

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 128-135, June 2009

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