Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 136-142 , June 2009

Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy

  • Wan Nordiana Rahman, MSc

      Affiliations

    • Medical Radiation Discipline, School Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    • ,
  • Nour Bishara, PhD

      Affiliations

    • Medical Radiation Discipline, School Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    • ,
  • Trevor Ackerly, MSc

      Affiliations

    • William Buckland Radiotherapy Centre, The Alfred Hospital, Prahran, Australia
    • ,
  • Cheng Fa He, PhD

      Affiliations

    • Medical Radiation Discipline, School Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    • The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Science, Urumqi, Xinjiang, China
    • ,
  • Price Jackson, BSc

      Affiliations

    • Medical Radiation Discipline, School Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    • ,
  • Christopher Wong, BSc

      Affiliations

    • Medical Radiation Discipline, School Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    • ,
  • Robert Davidson, PhD

      Affiliations

    • Medical Radiation Discipline, School Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    • ,
  • Moshi Geso, PhD

      Affiliations

    • Medical Radiation Discipline, School Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    • Corresponding Author InformationCorresponding author: Medical Radiation Discipline, School Medical Sciences, RMIT University, Victoria, Australia.

Received 29 September 2008 ,Accepted 13 January 2009.

References 

  1. Mello RS, Callisen H, Winter J, Kagan AR, Norman A. Radiation dose enhancement in tumors with iodine. Med Phys. 1983;10:75–78
  2. Mesa AV, Norman A, Solberg TD, Demarco JJ, Smathers JB. Dose distributions using kilovoltage x-rays and dose enhancement from iodine contrast agents. Phys Med Biol. 1999;44:1955–1968
  3. Robar JL, Riccio SA, Martin MA. Tumour dose enhancement using modified megavoltage photon beams and contrast media. Phys Med Biol. 2002;47:2433–2449
  4. Corde S, Joubert A, Adam JF, Charvet AM, Le Bas JF, Esteve F, et al. Synchrotron radiation based experimental determination of the optimal energy for cell radiotoxicity enhancement following photoelectric effect on stable iodinated compounds. Br J Cancer. 2004;91:544–551
  5. Esteve F, Corde S, Elleaume H, Adam JF, Joubert A, Charvet AM, et al. Enhanced radio sensitivity with iodinated contrast agents using monochromatic synchrotron x rays on human cancerous cells. Acad Radiol. 2002;9:S540–S543
  6. Dawson P, Penhaligon M, Smith E, Saunders J. Iodinated contrast agents as radiosensitisers. Br J Radiol. 1987;60:201–203
  7. Matsudaira H, Ueno AM, Furuno I. Iodine contrast medium sensitizes cultured mammalian cells to x rays but not to γ rays. Radiat Res. 1980;84:144–148
  8. Hainfeld JF, Slatkin DN, Smilowitz HM. The use of gold nanoparticles to enhance radiotherapy in mice. Phys Med Biol. 2004;49:309–315
  9. Hainfeld JF, Slatkin DN, Focella TM, Smilowitz HM. Gold nanoparticles: a new x-ray contrast agent. Br J Radiol. 2006;79:248–253
  10. Chien CC, Wang CH, Hua TE, Tseng PY, Yang TY, Hwu Y, et al. Synchrotron x-ray synthesized gold nanoparticles for tumor therapy. AIP Conf Proc. 2007;879:1808–1911
  11. Herold DM, Das IJ, Stobbe CC, Iyer RV, Chapman JD. Gold microspheres: a selective technique for producing biologically effective dose enhancement. Int J Radiat Biol. 2000;76:1357–1364
  12. Cho SH. Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study. Phys Med Biol. 2005;50:163–173
  13. Kong T, Zeng J, Wang X, Yang X, Yang J, McQuarrie S, et al. Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticles. Small. 2008;4:1537–1543
  14. Joubert A, Biston MC, Boudou C, Ravanat JL, Brochard T, Charvet AM, et al. Irradiation in presence of iodinated contrast agent results in radiosensitization of endothelial cells: consequences for computed tomography therapy. Int J Radiat Oncol Biol Phys. 2005;62:1486–1496
  15. Nativo P, Prior IA, Brust M. Uptake and intracellular fate of surface-modified gold nanoparticles. ACS Nano. 2008;2:1639–1644
  16. Chitrani BD, Ghazani AA, Chan WCW. Determining the size and shape dependence of gold nanoparticles uptake into mammalian cells. Nano Lett. 2006;4:662–668
  17. Tsai SW, Chen YY, Liaw JW. Compound cellular imaging of laser scanning confocal microscopy by using gold nanoparticles and dyes. Sensors. 2008;8:2306–2316
  18. Patra HK, Banerjee S, Chaudhuri U, Lahiri P, Dasgupta AK. Cell selective response to gold nanoparticles. Nanomedicine. 2007;3:111–119
  19. Tkachenko AG, Xie H, Liu Y, Coleman D, Ryan J, Glomm WR, et al. Cellular trajectories of peptide-modified gold particle complexes: comparison of nuclear localisation signals and peptide transduction domains. Bioconjug Chem. 2004;15:482–490
  20. Hubbell JH, Seltzer SM. Tables of x-ray mass attenuation coefficients and mass energy absorption coefficients 1 keV to 20 MeV for elements Z = 1 to 92 and 48 additional substances of dosimetric interest. Gaithersburg, MD: US Department of Commerce, Technology Administration, National Institute of Standards and Technology. Available from: http://physics.nist.gov/PhysRefData/XrayMassCoef/cover.html(1996; updated 2004 Jul)
  21. Khan FM. The physics of radiation therapy. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2003;
  22. Chang MY, Shiau AL, Chen YH, Chang CJ, Chen HH, Wu CL. Increased apoptotic potential and dose-enhancing effect of gold nanoparticles in combination with single-dose clinical electron beams on tumor-bearing mice. Cancer Sci. 2008;99:1479–1484
  23. Ortega R, Biston MC, Devès G, Bohic S, Carmona A. Nuclear microprobe determination of platinum quantitative distribution in rat brain tumors after cisplatin or carboplatin injection for PAT treatment of glioma. Nucl Instrum Methods. 2005;B231:321–325
  24. Laissue JA, Geiser G, Spanne PO, Dilmanian FA, Gebbers JO, Geiser M, et al. Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-Wiggler-generated x-rays. Int J Cancer. 1998;78:654–660

PII: S1549-9634(09)00052-5

doi: 10.1016/j.nano.2009.01.014

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 2 , Pages 136-142 , June 2009

Article Tools

* Image Usage & Resolution