Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 4 , Pages 443-451 , December 2009

Physical properties and biological activity of poly(butyl acrylate–styrene) nanoparticle emulsions prepared with conventional and polymerizable surfactants

  • Julio C. Garay-Jimenez, BS

      Affiliations

    • Center for Molecular Diversity in Drug Design, Discovery, and Delivery, Department of Chemistry, University of South Florida, Tampa, Florida, USA
    • ,
  • Danielle Gergeres

      Affiliations

    • Center for Molecular Diversity in Drug Design, Discovery, and Delivery, Department of Chemistry, University of South Florida, Tampa, Florida, USA
    • ,
  • Ashley Young, BS

      Affiliations

    • Center for Molecular Diversity in Drug Design, Discovery, and Delivery, Department of Chemistry, University of South Florida, Tampa, Florida, USA
    • ,
  • Daniel V. Lim, PhD

      Affiliations

    • Department of Biology, Advanced Biosensors Laboratory, University of South Florida, Tampa, Florida, USA
    • ,
  • Edward Turos, PhD

      Affiliations

    • Center for Molecular Diversity in Drug Design, Discovery, and Delivery, Department of Chemistry, University of South Florida, Tampa, Florida, USA
    • Corresponding Author InformationCorresponding author: Center for Molecular Diversity in Drug Design, Discovery, and Delivery, Department of Chemistry, CHE 205, 4202 East Fowler Avenue, University of South Florida, Tampa, Florida 33620, USA.

Received 14 October 2008 ,Accepted 21 January 2009.

References 

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  2. Abeylath S, Turos E. Glycosylated polyacrylate nanoparticles by emulsion polymerization. Carb Polym. 2007;70:32–37
  3. Turos E, Reddy GSK, Greenhalgh K, Ramaraju P, Abeylath SC, Jang S, et al. Penicillin-bound polyacrylate nanoparticles: restoring the activity of β-lactam antibiotics against MRSA. Bioorg Med Chem Lett. 2007;17:3468–3472
  4. Abeylath S, Turos E, Dickey S, Lim DV. Novel carbohydrated nanoparticle antibiotics for MRSA and Bacillus anthracis. Bioorg Med Chem. 2008;16:2412–2418
  5. Greenhalgh K, Turos E. In vivo studies of polyacrylate nanoparticle emulsions for topical and systemic applications. Nanomedicine. 2009;5:46–54
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 Sources of support (E.T.) include the National Institutes of Health (R01 AI01535) and National Science Foundation (NSF 0419903, NSF 0620572), the University of South Florida and the Florida Center of Excellence in Biomolecular Identification and Targeted Therapeutics (for a Graduate Multidisciplinary Scholarship to J.G.), and the University of South Florida Office of Technology Development for a Florida High Tech Corridor matching grant. E.T. is co-inventor on a US patent application by the University of South Florida for the polyacrylate nanoparticle antibiotics, the subject of this publication. Dr. Turos is also co-founder, chief scientific advisor, and shareholder of Nanopharma Technologies, Inc., a University of South Florida spin-out company. Nanopharma Technologies, Inc., has licensed the nanoparticles technology from the University of South Florida for potential commercial development.

PII: S1549-9634(09)00053-7

doi: 10.1016/j.nano.2009.01.015

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 4 , Pages 443-451 , December 2009

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