Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 4 , Pages 378-381 , December 2009

Adipocytes differentiation in the presence of Pluronic F127–coated carbon nanotubes

  • Giuseppe Bardi, PhD

      Affiliations

    • Institute of Neurosciences, National Research Council (CNR), Pisa, Italy
    • Corresponding Author InformationCorresponding author. Institute of Neurosciences, CNR, Via Moruzzi 1, 56124 Pisa, Italy.
  • ,
  • Orazio Vittorio, MSc

      Affiliations

    • Centre for Research in Microengineering (CRIM), Scuola Superiore Sant'Anna, Pisa, Italy
  • ,
  • Margherita Maffei, PhD

      Affiliations

    • Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy
  • ,
  • Tommaso Pizzorusso, PhD

      Affiliations

    • Department of Psychology, University of Florence, Florence, Italy
  • ,
  • Mario Costa, PhD

      Affiliations

    • Institute of Neurosciences, National Research Council (CNR), Pisa, Italy

Received 17 September 2008 ,Accepted 14 January 2009.

References 

  1. Waki H, Tontonoz P. Endocrine functions of adipose tissue. Annu Rev Pathol. 2007;2:31–56
  2. Gesta S, Tseng YH, Kahn CR. Developmental origin of fat: tracking obesity to its source. Cell. 2007;131:242–256
  3. Lacerda L, Bianco A, Prato M, Kostarelos K. Carbon nanotubes as nanomedicines: from toxicology to pharmacology. Adv Drug Deliv Rev. 2006;58:1460–1470
  4. Iijima S. Helical microtubules of graphitic carbon. Nature. 1991;354:56–58
  5. Prato M, Kostarelos K, Bianco A. Functionalized carbon nanotubes in drug design and discovery. Acc Chem Res. 2008;41:60–68
  6. Ntambi JM, Young-Cheul K. Adipocyte differentiation and gene expression. J Nutr. 2000;130:3122S–3126S
  7. Monteiro-Riviere NA, Inman AO, Wang YY, Nemanich RJ. Surfactant effects on carbon nanotube interactions with human keratinocytes. Nanomedicine. 2005;1:293–299
  8. Bardi G, Tognini P, Ciofani G, Raffa V, Costa M, Pizzorusso T. Pluronic-coated carbon nanotubes do not induce degeneration of cortical neurons in vivo and in vitro. Nanomedicine. 2009;5:96–104
  9. Hemmrich K, von Heimburg D. Biomaterials for adipose tissue engineering. Expert Rev Med Devices. 2006;3:635–645
  10. Kwon GS. Polymeric micelles for delivery of poorly water-soluble compounds. Crit Rev Ther Drug Carrier Syst. 2003;20:357–403
  11. Kostarelos K, Lacerda L, Pastorin G, Wu W, Wieckowski S, Luangsivilay J, et al. Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nat Nanotechnol. 2007;2:108–113
  12. Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol. 2008;3:423–428

 The work presented in this article has been supported by the NINIVE (Non-Invasive Nanotransducer for In Vivo Gene Therapy, STRP 033378) project, co-financed by the 6FP of the European Commission.

PII: S1549-9634(09)00054-9

doi: 10.1016/j.nano.2009.01.016

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 5, Issue 4 , Pages 378-381 , December 2009