Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 1 , Pages 64-69 , February 2010

Multifunctional magnetic nanoparticles for targeted delivery

  • Arun Kumar, PhD

      Affiliations

    • Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Tampa, Florida, USA
    • ,
  • Prasanna K. Jena, PhD

      Affiliations

    • Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Tampa, Florida, USA
    • ,
  • Sumita Behera, PhD

      Affiliations

    • TransGenex Nanobiotech Inc., Tampa, Florida, USA
    • ,
  • Richard F. Lockey, MD

      Affiliations

    • Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Tampa, Florida, USA
    • VA Hospital Research, James A. Haley Hospital, Tampa, Florida, USA
    • ,
  • Subhra Mohapatra, PhD

      Affiliations

    • Divison of Endocrinology, Department of Internal Medicine, University of South Florida, Tampa, Florida, USA
    • VA Hospital Research, James A. Haley Hospital, Tampa, Florida, USA
    • ,
  • Shyam Mohapatra, PhD

      Affiliations

    • Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Tampa, Florida, USA
    • VA Hospital Research, James A. Haley Hospital, Tampa, Florida, USA
    • Corresponding Author InformationCorresponding author: Division of Allergy and Immunology and Department of Internal Medicine, University of South Florida College of Medicine and VA Hospital, Tampa, Florida, USA.

Received 26 March 2008 ,Accepted 17 April 2009.

References 

  1. Berry CC, Curtis ASG. Functionalization of magnetic nanoparticles for application in biomedicine. J Phys D Appl Phys. 2003;36:R198–R206
  2. Lubbe AS, Alexiou C, Bergemann C. Clinical applications of magnetic drug targeting. J Surg Res. 2001;95:200–206
  3. Babincova M, Sourivong P, Leszczynska D, Babinec P. Blood-specific whole-body electromagnetic hyperthermia. Med Hypotheses. 2000;55:459–460
  4. Davis SS. Biomedical applications of nanotechnology—implications for drug targeting and gene therapy. Trends Biotechnol. 1997;15:217–224
  5. Lacava LM, Lacava ZG, Da Silva MF, Silva O, Chaves SB, Azevedo RB, et al. Magnetic resonance of a dextran-coated magnetic fluid intravenously administered in mice. Biophys J. 2001;80:2483–2486
  6. Sudimack J, Lee RJ. Targeted drug delivery via folate receptor. Adv Drug Del Rev. 2000;41:147–162
  7. Kumar A, Fal-Miyar V, García JA, Cerdeira A, Mohapatra S, Srikanth H, et al. Magnetoimpedance biosensor for Fe3O4 nanoparticles intracellular uptake evaluation. Appl Phys Lett. 2007;91:143902
  8. Katz E, Baron R, Willner I. Magnetoswitchable electrochemistry gated by alkyl-chain-functionalized magnetic nanoparticles: control of diffusional and surface-confined electrochemical processes. J Am Chem Soc. 2005;127:4060–4070
  9. Gaur U, Sahoo SK, De TK, Ghosh PC, Mitra A, Ghosh PK. Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system. Int J Pharm. 2000;202:1–10
  10. Simberg D, Duza T, Park JH, Essler M, Pilch J, Zhang L, et al. Biometric amplification of nanoparticle homing to tumors. Proc Natl Acad Sci USA. 2007;104:932–936
  11. Bonnemain B. Superparamagnetic agents in magnetic resonance imaging: physiological characteristics and clinical applications—a review. J Drug Target. 1998;6:167–174
  12. Wang YX, Hussain SM, Krestin GP. Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. Eur Radiol. 2001;11:2319–2331

 This work was supported by the National Institutes of Health (NIH) (grant 5RO1HL71101-01A2), the James A. Haley Veteran's Hospital, and the I-4 Corridor support and the Mabel and Ellsworth Simmons endowments to S.S.M.

PII: S1549-9634(09)00086-0

doi: 10.1016/j.nano.2009.04.002

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 1 , Pages 64-69 , February 2010

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