Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 1 , Pages 58-63 , February 2010

Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method

  • Mohammad Reza Avadi, PhD

      Affiliations

    • Faculty of Pharmacy, Azad University of Medical Sciences, Tehran, Iran
    • Hakim Pharmaceutical Company, Tehran, Iran
    • Corresponding Author InformationCorresponding author: Faculty of Pharmacy, Azad University of Medical Sciences, Tehran, Iran.
    • ,
  • Assal Mir Mohammad Sadeghi, PhD

      Affiliations

    • Hakim Pharmaceutical Company, Tehran, Iran
    • ,
  • Nasser Mohammadpour, PharmD

      Affiliations

    • Razi Vaccine and Sera Research Institute, Karaj, Iran
    • ,
  • Saideh Abedin, PharmD

      Affiliations

    • Hakim Pharmaceutical Company, Tehran, Iran
    • ,
  • Fatemeh Atyabi, PhD

      Affiliations

    • Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Rassoul Dinarvand, PhD

      Affiliations

    • Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    • ,
  • Morteza Rafiee-Tehrani, PhD

      Affiliations

    • Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Received 9 February 2009 ,Accepted 19 April 2009.

References 

  1. Cut F, Shi K, Zhang L, Tao A, Kawashima Y. Biodegradable nanoparticles loaded with insulin-phospholipid complex formal delivery: preparation, invitro characterization and in vivo evaluation. J Controlled Release. 2006;114:242–250
  2. Ma Z, Lim TM, Lim LY. Pharmacological activity of peroral chitosan-insulin nanoparticles in diebetic rats. Int J Pharm. 2005;293:271–280
  3. Sarmento B, Ferreira DC, Jorgensen L, VandeWeert M. Probing insulin's secondary structure after entrapment into alginate chitosan nanoparticles. Eur J Pharm Biopharm. 2007;65:10–17
  4. Owens DR, Zinman B, Bolli G. Alternative routes of insulin delivery. Diab Med. 2003;20:886–898
  5. Radwant MA, Aboul-Enein HY. The effect of oral absorption enhancers on the in-vivo performance of insulin-loaded poly ethylcyanoacrylate nanospheres in diabetic rats. J Microencap. 2002;19:225–235
  6. Steffansen B, Nielsen CU, Brodin B, Eriksson AH, Anderson R, Frokjaer S. Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption. Eur J Pharm Sci. 2004;21:3–16
  7. Lowe PJ, Temple CS. Calcitonin and insulin in isobutylcyanoacrylate nanoparticles: protection against proteases and effect on intestinal absorption in rats. J Pharm Pharmacol. 1994;46:547–552
  8. Janes KA, Calvo P, Alonso MJ. Polysaccharide colloidal particles as delivery systems for macromolecules. Adv Drug Del Rev. 2001;47:57–83
  9. Galindo-Rodriguez SA, Allemann E, Fessi H, Doelker E. Polymeric nanoparticles for oral delivery of drugs and vaccines: a critical evaluation of in vivo studies. Crit Rev Ther Drug Carrier Sys. 2005;22:419–464
  10. Longer MA, Cheng HS, Robinson JR. Bioadhesive polymers as platforms for oral controlled drug delivery III: oral delivery of chlorothiazide using a bioadhesive polymer. J Pharm Sci. 1985;74:406–411
  11. Dodane V, Vilivalam VD. Pharmaceutical application of chitosan. Pharm Sci Technol Today. 1998;1:246–253
  12. Illum L, Jabbal-Gill I, Hinchcliffe M. Chitosan as a novel nasal delivery system for vaccines. Adv Drug Del Rev. 2001;51:81–96
  13. Lehr CM, Bouwstra JA, Junginger HE. In vitro evaluation of mucoadhesive properties of chitosan and some other nautral polymers. Int J Pharm. 1992;78:43–48
  14. Bahardwaj TR, Kanwar M, Lai R, Gupta A. Natural guvis and modified natural gums as sustained release carriers. Drug Dev Ind Pharm. 2000;26:1025–1038
  15. Calvo P, Remunan-Lopez C, Vila-Jato JL, Alonso MJ. Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers.. J Appl Polym Sci. 1997;63:125–132
  16. Evans DF, Pye GE, Bramley R, Clark AG, Dyson TJ, Hardcastle JD. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut. 1988;29:1035–1041
  17. Wang X, Chi N, Tang X. Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targeting. Eur J Pharm Biopharm. 2008;70:735–740
  18. Mir-Mohammad Sadeghi A, Dorkoosh FA, Avadi MR, Saadat P, Rafiee-Tehrani M, Junginger HE. Preparation, characterization and antibacterial activities of chitosan, TMC and DEMC nanoparticles loaded with insulin using both the ionotropic gelation and polyelectrolyte complexation methods. Int J Pharm. 2008;355:299–306
  19. Rowe RC, Sheskey PJ, Owen SC. In: Hand book of pharmaceutical excipients. 5th ed.. London: Pharmaceutical Press; 2006;p. 1–3
  20. Ghaffari A, Avadi MR, Moghimi HR, Oskoui M, Bayati Kh, Rafiee-Tehrani M. Mechanistic analysis of drug release from theophylline pellets coated by films containing pectin, chitosan and Eudragit RS. Drug Dev Ind Pharm. 2008;34:390–402
  21. Ritger PL, Peppas NA. A simple equation for description of solute release I, Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J Controlled Release. 1987;5:23–36
  22. Cafalu WT. Concept strategies and feasibility of non-invasive insulin delivery. Diab Care. 2004;27:230–246
  23. Takeuchi H, Yamamoto H, Kawashima Y. Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv Drug Del Rev. 2001;47:39–54
  24. Jintapattanakit A, Junayaprasert V, Mao S, Sitterberg J, Bakowsky U, Kissel T. Peroral delivery of insulin using chitosan derivatives: a comparative study of polyelectrolyte nanocomplexes and nanoparticles. Int J Pharm. 2007;342:240–249

 No conflict of interest was reported by the authors of this article.

PII: S1549-9634(09)00092-6

doi: 10.1016/j.nano.2009.04.007

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 1 , Pages 58-63 , February 2010

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