Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 1 , Pages 1-8 , February 2010

Novel sorbents for removal of gadolinium-based contrast agents in sorbent dialysis and hemoperfusion: preventive approaches to nephrogenic systemic fibrosis

  • Wassana Yantasee, PhD

      Affiliations

    • Oregon Health and Science University, Portland, Oregon, USA
    • Corresponding Author InformationCorresponding author. Pacific Northwest National Laboratory (PNNL), Richland, WA 99352, USA.
    • ,
  • Glen E. Fryxell, PhD

      Affiliations

    • Pacific Northwest National Laboratory (PNNL), Richland, Washington, USA
    • ,
  • George A. Porter, MD

      Affiliations

    • Oregon Health and Science University, Portland, Oregon, USA
    • ,
  • Kanda Pattamakomsan, MS

      Affiliations

    • Pacific Northwest National Laboratory (PNNL), Richland, Washington, USA
    • ,
  • Vichaya Sukwarotwat, BS

      Affiliations

    • Pacific Northwest National Laboratory (PNNL), Richland, Washington, USA
    • ,
  • Wilaiwan Chouyyok, PhD

      Affiliations

    • Pacific Northwest National Laboratory (PNNL), Richland, Washington, USA
    • ,
  • View Koonsiripaiboon, BS

      Affiliations

    • Pacific Northwest National Laboratory (PNNL), Richland, Washington, USA
    • ,
  • Jide Xu, PhD

      Affiliations

    • University of California, Berkeley, California, USA
    • ,
  • Kenneth N. Raymond, PhD

      Affiliations

    • University of California, Berkeley, California, USA

Received 19 November 2008 ,Accepted 4 May 2009.

  • Image Result

    Chemical structures of SAMMS ligands.

    Chemical structures of SAMMS ligands.

  • Image Result

    Distribution coefficients of gadopentetate Gd measured on 1,2-HOPO-SAMMS and Darco KB-B activated carbon in pH-adjusted 0.1 M NaCl, initial [gadopentetate Gd] of 50 ppb and L/S of 5000 mL/g.

    Distribution coefficients of gadopentetate Gd measured on 1,2-HOPO-SAMMS and Darco KB-B activated carbon in pH-adjusted 0.1 M NaCl, initial [gadopentetate Gd] of 50 ppb and L/S of 5000 mL/g.

  • Image Result

    Adsorption kinetics of Gd3+ measured on 1,2-HOPO-SAMMS, activated carbon (AC), and zirconium phosphate (ZrP) in dialysate (pH 8.0), initial [Gd3+] of 100 μg/L, L/S of 5000 mL/g.

    Adsorption kinetics of Gd3+ measured on 1,2-HOPO-SAMMS, activated carbon (AC), and zirconium phosphate (ZrP) in dialysate (pH 8.0), initial [Gd3+] of 100 μg/L, L/S of 5000 mL/g.

  • Image Result

    Adsorption kinetics of gadopentetate Gd and gadodiamide Gd measured on 1,2-HOPO-SAMMS, initial [chelated Gd] of 100 μg/L, L/S of 5000 mL/g.

    Adsorption kinetics of gadopentetate Gd and gadodiamide Gd measured on 1,2-HOPO-SAMMS, initial [chelated Gd] of 100 μg/L, L/S of 5000 mL/g.

  • Image Result

    Adsorption isotherm of free Gd in dialysate (pH 8.0, L/S 100,000 mL/g), gadopentetate Gd in 0.1 M NaCl (pH 3.1, L/S 50,000 mL/g), and gadodiamide Gd in dialysate (pH 8.0, L/S 50,000 mL/g) measured on

    Adsorption isotherm of free Gd in dialysate (pH 8.0, L/S 100,000 mL/g), gadopentetate Gd in 0.1 M NaCl (pH 3.1, L/S 50,000 mL/g), and gadodiamide Gd in dialysate (pH 8.0, L/S 50,000 mL/g) measured on 1,2-HOPO-SAMMS.

 This work was partially supported by the Laboratory Directed Research and Development (LDRD) program at PNNL, National Institute of Environmental Health Sciences (NIEHS) grant no. R21 ES015620, and National Institute of Allergy and Infectious Disease (NIAID) grant no. R01 AI074064. A portion of research was performed using EMSL, a national scientific user facility sponsored by the Department of Energy's Office of Biological and Environmental Research and located at PNNL.

PII: S1549-9634(09)00093-8

doi: 10.1016/j.nano.2009.05.002

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 1 , Pages 1-8 , February 2010

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