Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 1 , Pages 93-102 , February 2010

Toxic and teratogenic silica nanowires in developing vertebrate embryos

  • Steve M. Nelson, PhD

      Affiliations

    • Department of Biological Sciences, Neuroscience Graduate Program, University of Idaho, Moscow, Idaho, USA
    • ,
  • Tarek Mahmoud, PhD

      Affiliations

    • Department of Chemistry, University of Idaho, Moscow, Idaho, USA
    • ,
  • Miles Beaux II, MS

      Affiliations

    • Department of Physics, University of Idaho, Moscow, Idaho, USA
    • ,
  • Pamela Shapiro, PhD

      Affiliations

    • Department of Chemistry, University of Idaho, Moscow, Idaho, USA
    • ,
  • David N. McIlroy, PhD

      Affiliations

    • Department of Physics, University of Idaho, Moscow, Idaho, USA
    • ,
  • Deborah L. Stenkamp, PhD

      Affiliations

    • Department of Biological Sciences, Neuroscience Graduate Program, University of Idaho, Moscow, Idaho, USA
    • Corresponding Author InformationCorresponding author.

Received 9 February 2009 ,Accepted 1 May 2009.

References 

  1. Rossin R, Muro S, Welch MJ, Muzykantov VR, Schuster DP. In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endothelium. J Nucl Med. 2008;49(1):103–111
  2. Santra S, Dutta D, Moudgil B. Functional dye-doped silica nanoparticles for bioimaging, diagnostics and therapeutics. Food Bioprod Process. 2005;83(2):136–140
  3. Goldberg M, Langer R, Jia X. Nanostructured materials for applications in drug delivery and tissue engineering. J Biomater Sci. 2007;18(3):241–268
  4. Beaux IIM, Wang L, Zhang D, Gangadean D, McIlroy D, Kwon N, et al. Fibronectin bonding to nanowires and their internalization by epithelial cells. J Biomed Nanotech. 2006;2(1):1–6
  5. Kwon N, Beaux IIM, Ebert C, Wang L, Lassiter B, Park Y, et al. Nanowire-based delivery of Escherichia coli O157 Shiga toxin 1 A subunit into human and bovine cells. Nano Lett. 2007;7(9):2718–2723
  6. Santra S, Yang H, Dutta D, Stanley JT, Holloway PH, Tan W, et al. TAT conjugated, FITC doped silica nanoparticles for bioimaging applications. Chem Commun. 2004;2810–2811
  7. Kumar M, Sameti M, Mohapatra S, Kong X, Lockey R, Bakowsky U, et al. Cationic silica nanoparticles as gene carriers: synthesis, characterization and transfection efficiency in vitro and in vivo. J Nanosci Nanotech. 2004;4(7):876–881
  8. Lee CH, Cheng SH, Wang YJ, Chen YC, Chen NT, Souris J, et al. Near-infrared mesoporous silica nanoparticles for optical imaging: characterization and in vivo biodistribution. Adv Funct Mater. 2008;19(2):215–222
  9. Luo D, Saltzman W. Nonviral gene delivery: thinking of silica. Gene Ther. 2006;13(7):585–586
  10. Chen Y, Chen J, Dong J, Jin Y. Comparing study of the effect of nanosized silicon dioxide and microsized silicon dioxide on fibrogenesis in rats. Toxicol Ind Health. 2004;20:21–27
  11. He X, Nie H, Wang K, Tan W, Wu X, Zhang P. In vivo study of biodistribution and urinary excretion of surface-modified silica nanoparticles. Anal Chem. 2008;80(24):9597–9603
  12. Ping W, He X, Wang K, Tan W, Ma D, Yang W, et al. Imaging breast cancer cells and tissues using peptide-labeled fluorescent silica nanoparticles. J Nanosci Nanotechnol. 2008;8(5):2483–2487
  13. Tan K, Cheang P, Ho I, Lam P, Hui K. Nanosized bioceramic particles could function as efficient gene delivery vehicles with target specificity for the spleen. Gene Ther. 2007;14(10):828–835
  14. Chen M, von Mikecz A. Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles. Exp Cell Res. 2005;305(1):51–62
  15. Choi D, McIlroy D, Nagler J, Aston E, Hrdlicka P, Gustin K, et al. One-dimensional silica structures and their application to the biological sciences. In:  Kumar C editors. Nanomaterials for the life sciences, Volume 2, Nanostructured oxides. Hoboken (NJ): John Wiley & Sons; 2009;p. 83–108
  16. Kneuer C, Sameti M, Bakowsky U, Schiestel T, Schirra H, Schmidt H, et al. A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro. Bioconjug Chem. 2000;11(6):926–932
  17. Luo D, Han E, Belcheva N, Saltzman W. A self-assembled, modular DNA delivery system mediated by silica nanoparticles. J Control Release. 2004;95(2):333–341
  18. Adili A, Crowe S, Beaux MF, Cantrell T, Shapiro PJ, McIlroy DN, et al. Differential cytotoxicity exhibited by silica nanowires and nanoparticles. Nanotoxicology. 2008;2(1):1–8
  19. Lin W, Huang YW, Zhou XD, Ma Y. In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol Appl Pharmacol. 2006;217(3):252–259
  20. Jin Y, Kannan S, Wu M, Zhao JX. Toxicity of luminescent silica nanoparticles to living cells. Chem Res Toxicol. 2007;20(8):1126–1133
  21. Yang H, Liu C, Yang D, Zhang H, Xi Z. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J Appl Toxicol. 2008;29(1):69–78
  22. Qi S, Yi C, Chen W, Fong CC, Lee ST, Yang M. Effects of silicon nanowires on HepG2 cell adhesion and spreading. Chem Biochem. 2007;8(10):1115–1118
  23. Bharali DJ, Klejbor I, Stachowiak EK, Dutta P, Roy I, Kaur N, et al. Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain. Proc Natl Acad Sci USA. 2005;102(32):11539–11544
  24. Park E, Park K. Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol Lett. 2009;184(1):18–25
  25. Borm PJA, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, et al. The potential risks of nanomaterials: a review carried out for ECETOC. Particle Fibre Toxicol. 2006;3(11):1–35
  26. Matsunaga E, Shiota K. Holoprosencephaly in human embryos: epidemiologic studies of 150 cases. Teratology. 1977;16(3):261–272
  27. Usenko CY, Harper SL, Tanguay RL. Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish. Toxicol Appl Pharmacol. 2007;229(1):44–55
  28. Harper S, Maddux B, Hutchison J, Tanguay R. Biodistribution and toxicity of nanomaterials in vivo: effects of composition, size, surface functionalization and route of exposure. NSTI-Nanotech. 2007;2:666–669
  29. Isaacson CW, Usenko CY, Tanguay RL, Field JA. Quantification of fullerenes by LC/ESI-MS and its application to in vivo toxicity assays. Anal Chem. 2007;79(23):9091–9097
  30. Wang Y, Qin W, Zhang J, Cao C, Zhang J, Jin Y, et al. Europium(III) complexes/silica hybrid nanospheres synthesized in microemulsion. J Nanosci Nanotechnol. 2008;8(3):1218–1220
  31. Yun H, Bang H, Lee WG, Lim H, Park J, Lee J, et al. Fluorescent intensity-based differential counting of FITC-doped silica nanoparticles: applications of CD4+ T-cell detection in microchip-type flowcytometers. Proc SPIE. 2006;6416:641605
  32. Santra S, Wang K, Tapec R, Tan W. Development of novel dye-doped silica nanoparticles for biomarker application. J Biomed Opt. 2001;6(2):160–166
  33. Rossi L, Shi L, Quina F, Rosenzweig Z. Stöber synthesis of monodispersed luminescent silica nanoparticles for bioanalytical assays. Langmuir. 2005;21(10):4277–4280
  34. Westerfield M. The zebrafish book: A guide for the laboratory use of the zebrafish (Danio rerio). 4th ed. Eugene (Ore): Oregon University of Oregon Press; 2000;
  35. Shkumatava A, Fischer S, Muller F, Strahle U, Neumann CJ. Sonic hedgehog, secreted by amacrine cells, acts as a short-range signal to direct differentiation and lamination in the zebrafish retina. Development (Cambridge, England). 2004;131(16):3849–3858
  36. Nasevicius A, Ekker SC. Effective targeted gene 'knockdown' in zebrafish. Nat Genet. 2000;26(2):216–220
  37. Tokumoto T, Tokumoto M, Horiguchi R, Ishikawa K, Nagahama Y. Diethylstilbestrol induces fish oocyte maturation. Proc Natl Acad Sci USA. 2004;101(10):3686–3690
  38. Chong M, Liao M, Drapeau P. The vesicular integral protein-like gene is essential for development of a mechanosensory system in zebrafish. Dev Neurobiol. 2008;68(12):1391–1405
  39. Takamiya M, Campos-Ortega JA. Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesis. Dev Dyn. 2006;235(4):978–997
  40. Ekker SC, Ungar AR, Greenstein P, von Kessler DP, Porter JA, Moon RT, et al. Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Curr Biol. 1995;5(8):944–955
  41. Stenkamp DL, Frey RA. Extraretinal and retinal hedgehog signaling sequentially regulate retinal differentiation in zebrafish. Dev Biol. 2003;258(2):349–363
  42. Cohen MM, Shiota K. Teratogenesis of holoprosencephaly. Am J Med Genet. 2002;109(1):1–15
  43. Tsuchiya T, Oguri I, Yamakoshi YN, Miyata N. Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo. FEBS Lett. 1996;393(1):139–145
  44. Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol. 2008;3(7):423–428

 Dr. McIlroy is the Vice President of Research of GoNano Technologies, Inc. The current article has no relationship to GoNano. No conflict of interest was reported by the authors of this article.

 This work was supported by the University of Idaho-BANTech Initiative and by NIH R01 EY012146 (D.L.S.).

PII: S1549-9634(09)00096-3

doi: 10.1016/j.nano.2009.05.003

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 1 , Pages 93-102 , February 2010

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