Translational nanomedicine: status assessment and opportunities

doi:10.1016/j.nano.2009.06.001

Nanomedicine: Nanotechnology, Biology and Medicine

Volume 5, Issue 3, September 2009, Pages 251-273

https://doi.org/10.1016/j.nano.2009.06.001 Get rights and content

Abstract

Nano-enabled technologies hold great promise for medicine and health. The rapid progress by the physical sciences/engineering communities in synthesizing nanostructures and characterizing their properties must be rapidly exploited in medicine and health toward reducing mortality rate, morbidity an illness imposes on a patient, disease prevalence, and general societal burden. A National Science Foundation–funded workshop, “Re-Engineering Basic and Clinical Research to Catalyze Translational Nanoscience,” was held 16–19 March 2008 at the University of Southern California. Based on that workshop and literature review, this article briefly explores scientific, economic, and societal drivers for nanomedicine initiatives; examines the science, engineering, and medical research needs; succinctly reviews the US federal investment directly germane to medicine and health, with brief mention of the European Union (EU) effort; and presents recommendations to accelerate the translation of nano-enabled technologies from laboratory discovery into clinical practice.

From the Clinical Editor

An excellent review paper based on the NSF funded workshop “Re-Engineering Basic and Clinical Research to Catalyze Translational Nanoscience” (16-19 March 2008) and extensive literature search, this paper briefly explores the current state and future perspectives of nanomedicine.

Section snippets

Health care needs with promising nano-enabled technology impact

An investment strategy to accelerate nanoscience into nano-enabled technology for medicine and health should reflect both health need (technology pull) as well as science push. Within this context, science and engineering of nanoscale structures is expected to make major contributions across the entire medicine and health spectrum ranging from mortality rate, morbidity an illness imposes on a patient, disease prevalence, and general societal burden.²⁹^,34, 35, 36 The following examples

Nanoscale science and engineering research needed to enable more effective technology

The considerable investment in nanoscience across the world has been leading to many new discoveries. In the second 5 years of the US NNI there is growing effort to identify potential applications for those discoveries and to accelerate their transition into innovative technology solutions to societal problems. Medicine and health provide fertile ground for this goal. For convenience this section is organized about the headings of “In Vivo and in Vitro Diagnostics”; “Drugs, Delivery, and

Present federal programs

Several US federal agencies fund pertinent health research. The foremost is the NIH. In addition, NASA is interested in medical practice in space; the DOD has an interest in warfighter health issues and battlefield medicine; the NSF provides the foundations of medicine in systems biology; the Environmental Protection Administration is concerned with impact on living systems in the environment; and the US Department of Agriculture is concerned with the impact on agriculture. The total federal

Recommendations

Research opportunities and challenges have been identified in each of the subcategories in the third section, “Nanoscale Science and Engineering Research Needed to Enable More Effective Technology”; they are many. It should be noted that more generic questions were addressed in this workshop and that the research funding levels and prioritization among these opportunities and challenges was beyond its scope. From the discussions at the “Re-Engineering Basic and Clinical Research to Catalyze

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: The Re-Engineering Basic and Clinical Research to Catalyze Translational Nanoscience workshop was funded by National Science Foundation award CBET 0805207.

View full text

Feature Article: Preclinical Nanomedicine, ReviewTranslational nanomedicine: status assessment and opportunities

Abstract

From the Clinical Editor

Section snippets

Health care needs with promising nano-enabled technology impact

Nanoscale science and engineering research needed to enable more effective technology

Present federal programs

Recommendations

The National Nanotechnology Initiative: research and development leading to a revolution in technology and industry, Supplement to the President's FY2009 Budget

The National Nanotechnology Initiative: FY2009 Budget and Highlights

Nanomedicine: current status and future prospects

FASEB J

NIH roadmap for medical research

European Technology Platform—Nanomedicine: Nanotechnology for Health

The handbook of nanomedicine

Nanomednet

Lab on a chip

NanoDDS’09 [homepage on the Internet]. Nanomedicine and drug delivery symposium—Indianapolis

AVS–Science and Technology of Materials, Interfaces, and Processing

ESF research conferences. Fostering collaboration across disciplines and generations

Nanotechnology for the healthcare challenges of the 21st century

The ethical dimensions of nanomedicine

Med Clin North Am

Nanotechnology: A Report of the U.S. Food and Drug Administration Nanotechnology Task Force, 23 July 2007

Strategy for nanotechnology-related environmental, health, and safety research

NIOSH Nanotechnology Safety and Health Research Program. Nanomaterials: a risk to health at work?

Towards predicting nano-biointeractions: an international assessment of nanotechnology environment, health and safety research needs

ICON

Nanotechnological medical devices and nanopharmaceuticals: the European regulatory framework and research needs

J Nanosci Nanotechnol

Magnetic nanoparticles for cancer therapy

Curr Nanosci

New Frontiers in Nanotechnology for Cancer Treatment

Urol Oncol

Inventories

The emerging nanomedicine landscape

Nat Biotechnol

Emerging nanopharmaceuticals

Nanomedicine

From bench to bedside: successful translational nanomedicine

Nanomedicine

The National Nanotechnology Initiative: second assessment and recommendations of the National Nanotechnology Advisory Panel, April 2008

Nanotechnological applications in medicine

Curr Opin Biotechnol

Applications of nanomaterials inside cells

Nano Today

The present and future of nanotechnology in human health care

Nanomedicine

Cancer facts and figures 2007

Nanotechnology platforms and physiological challenges for cancer therapeutics

Nanomedicine

Brain cancer diagnosis and therapy with nanoplatforms

Adv Drug Deliv Rev

Lab-on-a-chip devices for global health: past studies and future opportunities

Lab on a Chip

Lab-on-a-chip methods for point-of-care measurements of salivary biomarkers of periodontitis

Ann NY Acad Sci

Quantum dots—nano-sized probes for the exploration of cellular and intracellular targeting

Eur J Pharm Biopharm

Intracellular delivery of core-shell fluorescent silica nanoparticles

Biomaterials

Effect of plasmonic gold nanoparticles on benign and malignant cellular autofluorescence: a Novel probe for fluorescence based detection of cancer

Technol Cancer Res Treat

Nanoparticles for bioimaging

Adv Colloid Interface Sci

Nanoprobes for medical diagnostics: current status of nanotechnology in molecular imaging

Curr Nanosci

Fluorescent core-shell silica nanoparticles: towards "lab on a particle" architectures for nanobiotechnology

Chem Soc Rev

Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging

Biochem Soc Trans

Delivery systems to increase the selectivity of antibiotics in phagocytic cells

J Control Release

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Mol Cancer Ther

Feature Article: Preclinical Nanomedicine, Review
Translational nanomedicine: status assessment and opportunities