Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 2 , Pages 277-288 , April 2010

Interactions of single-wall carbon nanotubes with endothelial cells

  • Adriana Albini, PhD

      Affiliations

    • Polo Scientifico e Tecnologico, IRCCS Multimedica, Milano, Italy
    • ,
  • Valentina Mussi, PhD

      Affiliations

    • Nanomed Labs, CBA-Centro Biotecnologie Avanzate, Genova; and Physics Department, University of Genova, Genova, Italy
    • ,
  • Alessandro Parodi, PhD

      Affiliations

    • Laboratorio di Biologia Vascolare, CBA-Centro Biotecnologie Avanzate, Genova, Italy
    • ,
  • Agostina Ventura, PhD

      Affiliations

    • Laboratorio di Biologia Vascolare, CBA-Centro Biotecnologie Avanzate, Genova, Italy
    • ,
  • Elisa Principi, MS

      Affiliations

    • Laboratorio di Biologia Vascolare, CBA-Centro Biotecnologie Avanzate, Genova, Italy
    • ,
  • Sara Tegami, MS

      Affiliations

    • Nanomed Labs, CBA-Centro Biotecnologie Avanzate, Genova; and Physics Department, University of Genova, Genova, Italy
    • ,
  • Massimiliano Rocchia, PhD

      Affiliations

    • Thermo Fisher Scientific, Rodano, Milano, Italy
    • ,
  • Enrico Francheschi, PhD

      Affiliations

    • Chemistry and Industrial Chemistry Department, University of Genova, Genova, Italy
    • ,
  • Ilaria Sogno, MS

      Affiliations

    • Polo Scientifico e Tecnologico, IRCCS Multimedica, Milano, Italy
    • ,
  • Rosaria Cammarota, MS

      Affiliations

    • Polo Scientifico e Tecnologico, IRCCS Multimedica, Milano, Italy
    • ,
  • Giovanna Finzi, MD, PhD

      Affiliations

    • Università degli Studi dell'Insubria, Varese, Italy
    • ,
  • Fausto Sessa, MD

      Affiliations

    • Polo Scientifico e Tecnologico, IRCCS Multimedica, Milano, Italy
    • Università degli Studi dell'Insubria, Varese, Italy
    • ,
  • Douglas McClain Noonan, PhD

      Affiliations

    • Polo Scientifico e Tecnologico, IRCCS Multimedica, Milano, Italy
    • Università degli Studi dell'Insubria, Varese, Italy
    • Corresponding Author InformationCorresponding author: Università degli Studi dell'Insubria, Facoltà di Medicina e Chirurgia, Dipartimento di Scienze Cliniche e Biologiche, 21100 Varese, Italy.
    • ,
  • Ugo Valbusa, PhD

      Affiliations

    • Nanomed Labs, CBA-Centro Biotecnologie Avanzate, Genova; and Physics Department, University of Genova, Genova, Italy

Received 23 March 2009 ,Accepted 2 August 2009.

References 

  1. Fraczek A, Menaszek E, Paluszkiewicz C, Blazewicz M. Comparative in vivo biocompatibility study of single- and multi-wall carbon nanotubes. Acta Biomater. 2008;4(6):1593–1602
  2. Dai H. Carbon nanotubes: synthesis, integration, and properties. Accounts Chem Res. 2002;35(12):1035–1044
  3. Tasis D, Tagmatarchis N, Bianco A, Prato M. Chemistry of carbon nanotubes. Chem Rev. 2006;106(3):1105–1136
  4. Bianco A, Kostarelos K, Partidos CD, Prato M. Biomedical applications of functionalised carbon nanotubes. Chem Commun (Cambridge. England). 2005;7(5):571–577
  5. Shin JY, Premkumar T, Geckeler KE. Dispersion of single-walled carbon nanotubes by using surfactants: are the type and concentration important?. Chemistry (Weinheim an der Bergstrasse, Germany). 2008;14(20):6044–6048
  6. Yehia HN, Draper RK, Mikoryak C, Walker EK, Bajaj P, Musselman IH, et al. Single-walled carbon nanotube interactions with HeLa cells. J Nanobiotechnol. 2007;5:8
  7. Raja PM, Connolley J, Ganesan GP, Ci L, Ajayan PM, Nalamasu O, et al. Impact of carbon nanotube exposure, dosage and aggregation on smooth muscle cells. Toxicol Lett. 2007;169(1):51–63
  8. Lam CW, James JT, McCluskey R, Hunter RL. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci. 2004;77(1):126–134
  9. Prato M, Kostarelos K, Bianco A. Functionalized carbon nanotubes in drug design and discovery. Accounts Chem Res. 2008;41(1):60–68
  10. McDevitt MR, Chattopadhyay D, Kappel BJ, Jaggi JS, Schiffman SR, Antczak C, et al. Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J Nucl Med. 2007;48(7):1180–1189
  11. Meng J, Song L, Xu H, Kong H, Wang C, Guo X, et al. Effects of single-walled carbon nanotubes on the functions of plasma proteins and potentials in vascular prostheses. Nanomedicine: NBM. 2005;1(2):136–142
  12. Hampel S, Kunze D, Haase D, Kramer K, Rauschenbach M, Ritschel M, et al. Carbon nanotubes filled with a chemotherapeutic agent: a nanocarrier mediates inhibition of tumor cell growth. Nanomedicine (London, England). 2008;3(2):175–182
  13. Ferrara N, Mass RD, Campa C, Kim R. Targeting VEGF-A to treat cancer and age-related macular degeneration. Annu Rev Med. 2007;58:491–504
  14. Liu Z, Davis C, Cai W, He L, Chen X, Dai H. Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc Natl Acad Sci U S A. 2008;105(5):1410–1415
  15. Singh R, Pantarotto D, Lacerda L, Pastorin G, Klumpp C, Prato M, et al. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci U S A. 2006;103(9):3357–3362
  16. Decuzzi P, Pasqualini R, Arap W, Ferrari M. Intravascular delivery of particulate systems: does geometry really matter?. Pharm Res. 2009;26(1):235–243
  17. Gentile F, Curcio A, Indolfi C, Ferrari M, Decuzzi P. The margination propensity of spherical particles for vascular targeting in the microcirculation. J Nanobiotechnol. 2008;6:9
  18. Tanaka T, Decuzzi P, Cristofanilli M, Sakamoto JH, Tasciotti E, Robertson FM, et al. Nanotechnology for breast cancer therapy. Biomed Microdevices. 2009;11(1):49–63
  19. Liu ZCW, He L, Nakayama N, Sun X, Chen X, Dai H. In vivo biodistrbution and higly efficient tumor targeting of carbon nanotubes in mice. Nat Nanotechnol. 2007;2(1):47–52
  20. Lacerda L, Bianco A, Prato M, Kostarelos K. Carbon nanotubes as nanomedicines: from toxicology to pharmacology. Adv Drug Delivery Rev. 2006;58(14):1460–1470
  21. Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol. 2008;3(7):423–428
  22. Helland A, Wick P, Koehler A, Schmid K, Som C. Reviewing the environmental and human health knowledge base of carbon nanotubes. Environ Health Perspectives. 2007;115(8):1125–1131
  23. Takagi A, Hirose A, Nishimura T, Fukumori N, Ogata A, Ohashi N, et al. Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci. 2008;33(1):105–116
  24. Osswald S, Havel M, Gogotsi Y. Monitoring oxidation of multiwalled carbon nanotubes by Raman spectroscopy. J Raman Spectrosc. 2007;38(6):728–736
  25. Chakraborty S, Chattopadhyay J, Peng H, Chen Z, Mukherjee A, Arvidson RS, et al. Surface area measurement of functionalized single-walled carbon nanotubes. J Phys Chem. 2006;110(49):24812–24815
  26. Tosetti F, Vene R, Arena G, Morini M, Minghelli S, Noonan DM, et al. N-(4-hydroxyphenyl)retinamide inhibits retinoblastoma growth through reactive oxygen species-mediated cell death. Mol Pharmacol. 2003;63(3):565–573
  27. Albini A, Benelli R. The chemoinvasion assay: a method to assess tumor and endothelial cell invasion and its modulation. Nat Protoc. 2007;2(3):504–511
  28. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65(1-2):55–63
  29. Borenfreund E, Puerner JA. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol Lett. 1985;24(2-3):119–124
  30. Riddell RJ, Clothier RH, Balls M. An evaluation of three in vitro cytotoxicity assays. Food Chem Toxicol. 1986;24(6-7):469–471
  31. Itkis ME, Perea DE, Niyogi S, Love J, Tang J, Yu A, et al Optimization of the Ni-Y catalyst composition in bulk electric arc synthesis of single-walled carbon nanotubes by use of near-infrared spectroscopy. J Phys Chem B. 2004;108(34):12770–12775
  32. Dillon ACGT, Parilla PA, Alleman JL, Jones KM, Heben MJ. Evaluating the purity of single-wall nanotube materials. J Mater Res Soc Symp Proc. 2001;633(A5):2.1–2.6
  33. Arepalli SNP, Gorelik O, Hadjiev VG, Holmes W, Files B, Yowell L. Protocol for the characterization of single-wall carbon nanotube material quality. Carbon. 2004;42(8-9):1783–1791
  34. Itkis ME, Perea DE, Jung R, Niyogi S, Haddon RC. Comparison of analytical techniques for purity evaluation of single-walled carbon nanotubes. J Am Chem Soc. 2005;127(10):3439–3448
  35. Moon JMAK, Soo Park YHLY, Su Park DJBG. High-yield purification process of singlewalled carbon nanotubes. J Phys Chem B. 2001;105(24):5677–5681
  36. Murugesan S, Mousa SA, O'Connor LJ, Lincoln DW, Linhardt RJ. Carbon inhibits vascular endothelial growth factor- and fibroblast growth factor-promoted angiogenesis. FEBS Lett. 2007;581(6):1157–1160
  37. Radomski A, Jurasz P, Alonso-Escolano D, Drews M, Morandi M, Malinski T, et al. Nanoparticle-induced platelet aggregation and vascular thrombosis. Br J Pharmacol. 2005;146(6):882–893
  38. Worle-Knirsch JM, Pulskamp K, Krug HF. Oops they did it again! Carbon nanotubes hoax scientists in viability assays. Nanoletters. 2006;6(6):1261–1268

 This study was supported by a grant from the Comitato Interministeriale per la Programmazione Economica (CIPE) and by funds from the Compagnia di San Paolo to CBA and the AIRC (Associazione Italiana per la Ricerca sul Cancro) to Multimedica Onlus.

PII: S1549-9634(09)00170-1

doi: 10.1016/j.nano.2009.08.001

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 2 , Pages 277-288 , April 2010

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