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Volume 6, Issue 2 , Pages 201-209 , April 2010

Radioactive gold nanoparticles in cancer therapy: therapeutic efficacy studies of GA-¹⁹⁸AuNP nanoconstruct in prostate tumor–bearing mice

Nripen Chanda, PhD
- Department of Radiology, University of Missouri, Columbia, Missouri, USA
Para Kan, MS
- Department of Chemistry, University of Missouri, Columbia, Missouri, USA
Lisa D. Watkinson, MS
- Departments of Medical Pharmacology and Physiology, and of Veterinary Medicine, and Harry S. Truman Veterans Administration Medical Center, University of Missouri, Columbia, Missouri, USA
Ravi Shukla, PhD
- Department of Radiology, University of Missouri, Columbia, Missouri, USA
Ajit Zambre, PhD
- Department of Radiology, University of Missouri, Columbia, Missouri, USA
Terry L. Carmack, MS
- Departments of Medical Pharmacology and Physiology, and of Veterinary Medicine, and Harry S. Truman Veterans Administration Medical Center, University of Missouri, Columbia, Missouri, USA
Hendrik Engelbrecht, PhD
- Missouri University Research Reactor, University of Missouri, Columbia, Missouri, USA
John R. Lever, PhD
- Departments of Medical Pharmacology and Physiology, and of Veterinary Medicine, and Harry S. Truman Veterans Administration Medical Center, University of Missouri, Columbia, Missouri, USA
Kavita Katti, BS
- Department of Radiology, University of Missouri, Columbia, Missouri, USA
Genevieve M. Fent, DVM
- Departments of Medical Pharmacology and Physiology, and of Veterinary Medicine, and Harry S. Truman Veterans Administration Medical Center, University of Missouri, Columbia, Missouri, USA
Stan W. Casteel, DVM, PhD
- Departments of Medical Pharmacology and Physiology, and of Veterinary Medicine, and Harry S. Truman Veterans Administration Medical Center, University of Missouri, Columbia, Missouri, USA
C. Jeffrey Smith, PhD
- Department of Radiology, University of Missouri, Columbia, Missouri, USA
- Departments of Medical Pharmacology and Physiology, and of Veterinary Medicine, and Harry S. Truman Veterans Administration Medical Center, University of Missouri, Columbia, Missouri, USA
- Missouri University Research Reactor, University of Missouri, Columbia, Missouri, USA
William H. Miller, PhD
- Missouri University Research Reactor, University of Missouri, Columbia, Missouri, USA
Silvia Jurisson, PhD
- Department of Chemistry, University of Missouri, Columbia, Missouri, USA
- Nuclear Science and Engineering Institute, University of Missouri, Columbia, Missouri, USA
- Department of Nuclear Engineering, University of Missouri, Columbia, Missouri, USA
Evan Boote, PhD
- Department of Radiology, University of Missouri, Columbia, Missouri, USA
J. David Robertson, PhD
- Department of Chemistry, University of Missouri, Columbia, Missouri, USA
- Missouri University Research Reactor, University of Missouri, Columbia, Missouri, USA
- Nuclear Science and Engineering Institute, University of Missouri, Columbia, Missouri, USA
- Department of Nuclear Engineering, University of Missouri, Columbia, Missouri, USA
Cathy Cutler, PhD
- Department of Chemistry, University of Missouri, Columbia, Missouri, USA
- Missouri University Research Reactor, University of Missouri, Columbia, Missouri, USA
- Nuclear Science and Engineering Institute, University of Missouri, Columbia, Missouri, USA
- Department of Nuclear Engineering, University of Missouri, Columbia, Missouri, USA
Marina Dobrovolskaia, PhD
- Nanotechnology Characterization Laboratory, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, Maryland, USA
Raghuraman Kannan, PhD
- Department of Radiology, University of Missouri, Columbia, Missouri, USA
- Nanoparticle Biochem, Inc., Columbia, Missouri, USA
- Corresponding author: Department of Radiology, University of Missouri–Columbia, Columbia, MO 65211, USA.
Kattesh V. Katti, PhD, DSc, FRSC
- Department of Radiology, University of Missouri, Columbia, Missouri, USA
- Missouri University Research Reactor, University of Missouri, Columbia, Missouri, USA
- Nanoparticle Biochem, Inc., Columbia, Missouri, USA
- Corresponding author: Department of Radiology, University of Missouri–Columbia, Columbia, MO 65211, USA.

Received 9 September 2009 ,Accepted 3 November 2009.

Title	About	Type	File Size
Figure S1	Schematic protocol for biocompatibility studies of GA-AuNPs. (A) Hemolysis assay. (B) Platelet aggregation assay. Isoton II solvent was from Beckman Coulter (Brea, California). (c) Complement activation assay. CMH, cyanmethemoglobin; PRP, platelet-rich plasma; TBH, total blood hemoglobin.		0 MB

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This research was supported by grants from the National Institutes of Health–National Cancer Institute under the Cancer Nanotechnology Platform Program: 5R01CA119412-01, NIH-1R21CA128460-01, NIH-SBIR-Contract No. 241, and University of Missouri Research Board Program: C8761 RB 06-030.

PII: S1549-9634(09)00252-4

doi: 10.1016/j.nano.2009.11.001

« Previous Next » Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 2 , Pages 201-209 , April 2010