Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 2 , Pages 201-209 , April 2010

Radioactive gold nanoparticles in cancer therapy: therapeutic efficacy studies of GA-198AuNP nanoconstruct in prostate tumor–bearing mice

  • Nripen Chanda, PhD

      Affiliations

    • Department of Radiology, University of Missouri, Columbia, Missouri, USA
    • ,
  • Para Kan, MS

      Affiliations

    • Department of Chemistry, University of Missouri, Columbia, Missouri, USA
    • ,
  • Lisa D. Watkinson, MS

      Affiliations

    • Departments of Medical Pharmacology and Physiology, and of Veterinary Medicine, and Harry S. Truman Veterans Administration Medical Center, University of Missouri, Columbia, Missouri, USA
    • ,
  • Ravi Shukla, PhD

      Affiliations

    • Department of Radiology, University of Missouri, Columbia, Missouri, USA
    • ,
  • Ajit Zambre, PhD

      Affiliations

    • Department of Radiology, University of Missouri, Columbia, Missouri, USA
    • ,
  • Terry L. Carmack, MS

      Affiliations

    • Departments of Medical Pharmacology and Physiology, and of Veterinary Medicine, and Harry S. Truman Veterans Administration Medical Center, University of Missouri, Columbia, Missouri, USA
    • ,
  • Hendrik Engelbrecht, PhD

      Affiliations

    • Missouri University Research Reactor, University of Missouri, Columbia, Missouri, USA
    • ,
  • John R. Lever, PhD

      Affiliations

    • Departments of Medical Pharmacology and Physiology, and of Veterinary Medicine, and Harry S. Truman Veterans Administration Medical Center, University of Missouri, Columbia, Missouri, USA
    • ,
  • Kavita Katti, BS

      Affiliations

    • Department of Radiology, University of Missouri, Columbia, Missouri, USA
    • ,
  • Genevieve M. Fent, DVM

      Affiliations

    • Departments of Medical Pharmacology and Physiology, and of Veterinary Medicine, and Harry S. Truman Veterans Administration Medical Center, University of Missouri, Columbia, Missouri, USA
    • ,
  • Stan W. Casteel, DVM, PhD

      Affiliations

    • Departments of Medical Pharmacology and Physiology, and of Veterinary Medicine, and Harry S. Truman Veterans Administration Medical Center, University of Missouri, Columbia, Missouri, USA
    • ,
  • C. Jeffrey Smith, PhD

      Affiliations

    • Department of Radiology, University of Missouri, Columbia, Missouri, USA
    • Departments of Medical Pharmacology and Physiology, and of Veterinary Medicine, and Harry S. Truman Veterans Administration Medical Center, University of Missouri, Columbia, Missouri, USA
    • Missouri University Research Reactor, University of Missouri, Columbia, Missouri, USA
    • ,
  • William H. Miller, PhD

      Affiliations

    • Missouri University Research Reactor, University of Missouri, Columbia, Missouri, USA
    • ,
  • Silvia Jurisson, PhD

      Affiliations

    • Department of Chemistry, University of Missouri, Columbia, Missouri, USA
    • Nuclear Science and Engineering Institute, University of Missouri, Columbia, Missouri, USA
    • Department of Nuclear Engineering, University of Missouri, Columbia, Missouri, USA
    • ,
  • Evan Boote, PhD

      Affiliations

    • Department of Radiology, University of Missouri, Columbia, Missouri, USA
    • ,
  • J. David Robertson, PhD

      Affiliations

    • Department of Chemistry, University of Missouri, Columbia, Missouri, USA
    • Missouri University Research Reactor, University of Missouri, Columbia, Missouri, USA
    • Nuclear Science and Engineering Institute, University of Missouri, Columbia, Missouri, USA
    • Department of Nuclear Engineering, University of Missouri, Columbia, Missouri, USA
    • ,
  • Cathy Cutler, PhD

      Affiliations

    • Department of Chemistry, University of Missouri, Columbia, Missouri, USA
    • Missouri University Research Reactor, University of Missouri, Columbia, Missouri, USA
    • Nuclear Science and Engineering Institute, University of Missouri, Columbia, Missouri, USA
    • Department of Nuclear Engineering, University of Missouri, Columbia, Missouri, USA
    • ,
  • Marina Dobrovolskaia, PhD

      Affiliations

    • Nanotechnology Characterization Laboratory, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, Maryland, USA
    • ,
  • Raghuraman Kannan, PhD

      Affiliations

    • Department of Radiology, University of Missouri, Columbia, Missouri, USA
    • Nanoparticle Biochem, Inc., Columbia, Missouri, USA
    • Corresponding Author InformationCorresponding author: Department of Radiology, University of Missouri–Columbia, Columbia, MO 65211, USA.
    • ,
  • Kattesh V. Katti, PhD, DSc, FRSC

      Affiliations

    • Department of Radiology, University of Missouri, Columbia, Missouri, USA
    • Missouri University Research Reactor, University of Missouri, Columbia, Missouri, USA
    • Nanoparticle Biochem, Inc., Columbia, Missouri, USA
    • Corresponding Author InformationCorresponding author: Department of Radiology, University of Missouri–Columbia, Columbia, MO 65211, USA.

Received 9 September 2009 ,Accepted 3 November 2009.

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 This research was supported by grants from the National Institutes of Health–National Cancer Institute under the Cancer Nanotechnology Platform Program: 5R01CA119412-01, NIH-1R21CA128460-01, NIH-SBIR-Contract No. 241, and University of Missouri Research Board Program: C8761 RB 06-030.

PII: S1549-9634(09)00252-4

doi: 10.1016/j.nano.2009.11.001

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 2 , Pages 201-209 , April 2010

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