Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 3 , Pages 453-462, June 2010

Release dynamics of ciprofloxacin from swellable nanocarriers of poly(2-hydroxyethyl methacrylate): an in vitro study

  • Raje Chouhan, MSc
  • ,
  • Anil K. Bajpai, PhD

      Affiliations

    • Corresponding Author InformationCorresponding author: Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur (MP) 482001, India.

Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, India

Received 9 July 2009; accepted 18 November 2009. published online 30 December 2009.

Abstract 

Swellable polymeric nanosystems have emerged as promising materials in drug release technologies. Such systems have shown potential in releasing antibiotic drugs and to do so controllably. In the present investigation poly(2-hydroxyethyl methacrylate) nanoparticles were synthesized by suspension polymerization of 2-hydroxyethyl methacrylate and characterized by various techniques such as Fourier transform–infrared spectrometry, scanning electron microscopy, particle size analysis, and surface charge measurements. The synthesized nanoparticles were swellable in water and showed promise to function as a swelling controlled-release system. The release kinetics of drug-loaded particles was studied in phosphate-buffered saline (PBS) using ciprofloxacin as a model antibacterial drug. The chemical stability of the pure and released drug was also assessed in PBS (pH 7.4), acidic (pH 1.8), and alkaline (pH 8.6) solutions. The in vitro blood compatibility of nanoparticles was also investigated in terms of hemolysis tests. The drug-loaded nanoparticles were also examined for their antibacterial and blood-compatible behaviors.

From the Clinical Editor

Swellable polymeric nanosystems have emerged as promising materials in drug release technologies. In this paper, the release kinetics, antimicrobial properties and in vitro “blood compatibility” is reported for a specific swellable polymeric nanosystem.

Key words: Nanoparticles, Controlled release, Poly(2-hydroxyethyl methacrylate), Ciprofloxacin, Blood compatibility

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 No conflict of interest was reported by the authors of this article.

PII: S1549-9634(09)00259-7

doi:10.1016/j.nano.2009.11.006

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 3 , Pages 453-462, June 2010