Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 5 , Pages 681-688 , October 2010

Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles

  • Fidel Martinez-Gutierrez, MSc

      Affiliations

    • Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México
  • ,
  • Peggy L. Olive, PhD

      Affiliations

    • British Columbia Research Centre, Vancouver, British Columbia, Canada
  • ,
  • Adriana Banuelos, PhD

      Affiliations

    • British Columbia Research Centre, Vancouver, British Columbia, Canada
  • ,
  • Erasmo Orrantia, PhD

      Affiliations

    • Centro de Investigaciones de Materiales Avanzados, Chihuahua, México
  • ,
  • Nereyda Nino, PhD

      Affiliations

    • Facultad de Ciencias, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México
  • ,
  • Elpidio Morales Sanchez, PhD

      Affiliations

    • Departamento de Fisico Matematicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México
  • ,
  • Facundo Ruiz, PhD

      Affiliations

    • Facultad de Ciencias, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México
  • ,
  • Horacio Bach, PhD

      Affiliations

    • Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia, Canada
    • Corresponding Author InformationCorresponding author: Department of Medicine, Division of Infectious Diseases, University of British Columbia, 2733 Heather Street, Vancouver, British Columbia, Canada V5Z 3J5.
  • ,
  • Yossef Av-Gay, PhD

      Affiliations

    • Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia, Canada

Received 28 October 2009 ,Accepted 2 February 2010.

References 

  1. Kim JS, Kuk E, Yu KN, Kim JH, Park SJ, Lee HJ, et al. Antimicrobial effects of silver nanoparticles. Nanomed Nanotechnol Biol Med. 2007;3:95–101
  2. Wang P. Nanoscale biocatalyst systems. Curr Opinion Biotechnol. 2006;17:574–579
  3. Zhang L, Gu FX, Chan JM, Wang AZ, Langer RS, Farokhzad OC. Nanoparticles in medicine: therapeutic applications and developments. Clin Pharmacol Ther. 2008;83:761–769
  4. Hong B, Kai J, Ren Y, Han J, Zou Z, Ahn CH, et al. Highly sensitive rapid, reliable, and automatic cardiovascular disease diagnosis with nanoparticle fluorescence enhancer and MEMS. Adv Exp Med Biol. 2008;614:265–273
  5. Chau CF, Wu SH, Yen GC. The development of regulations for food nanotechnology. Trends in Food Sci Technol. 2007;18:269–280
  6. Vigneshwaran N, Kathe AA, Varadarajan PV, Nachane RP, Balasubramanya RH. Functional finishing of cotton fabrics using silver nanoparticles. J Nanosci Nanotechnol. 2007;7:1893–1897
  7. Conlon JM, Kolodziejek J, Nowotny N. Antimicrobial peptides from ranid frogs: taxonomic and phylogenetic markers and a potential source of new therapeutic agents. Biochim Biophys Acta. 2004;1696:1–14
  8. Paddle-Ledinek JE, Nasa Z, Cleland HJ. Effect of different wound dressings on cell viability and proliferation. Plastic Reconstruct Surg. 2006;117:110S–118S
  9. Ulkur E, Oncul O, Karagoz H, Yeniz E, Celikoz B. Comparison of silver-coated dressing (Acticoat), chlorhexidine acetate 0.5% (Bactigrass), and fusidic acid 2% (Fucidin) for topical antibacterial effect in methicillin-resistant Staphylococci-contaminated, full-skin thickness rat burn wounds. Burns. 2005;31:874–877
  10. Samuel U, Guggenbichler JP. Prevention of catheter-related infections: the potential of a new nano-silver impregnated catheter. Int J Antimicrob Agents. 2004;23(Suppl 1):S75–S78
  11. Gosheger G, Hardes J, Ahrens H, Streitburger A, Buerger H, Erren M, et al. Silver-coated megaendoprostheses in a rabbit model—an analysis of the infection rate and toxicological side effects. Biomaterials. 2004;25:5547–5556
  12. Nomiya K, Yoshizawa A, Tsukagoshi K, Kasuga NC, Hirakawa S, Watanabe J. Synthesis and structural characterization of silver(I), aluminium(III) and cobalt(II) complexes with 4-isopropyltropolone (hinokitiol) showing noteworthy biological activities. Action of silver(I)-oxygen bonding complexes on the antimicrobial activities. J Inorg Biochem. 2004;98:46–60
  13. Gupta A, Silver S. Silver as a biocide: will resistance become a problem?. Nat Biotechnol. 1998;16:888
  14. Feng QL, Wu J, Chen GQ, Cui FZ, Kim TN, Kim JO. A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus. J Biomed Mater Res. 2000;52:662–668
  15. Matsumura Y, Yoshikata K, Kunisaki S, Tsuchido T. Mode of bactericidal action of silver zeolite and its comparison with that of silver nitrate. Appl Environ Microbiol. 2003;69:4278–4281
  16. Gupta A, Maynes M, Silver S. Effects of halides on plasmid-mediated silver resistance in Escherichia coli. Appl Environ Microbiol. 1998;64:5042–5045
  17. Hsin YH, Chen CF, Huang S, Shih TS, Lai PS, Chueh PJ. The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. Toxicol Lett. 2008;179:130–139
  18. Sondi I, Salopek-Sondi B. Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. J Colloid Interface Sci. 2004;275:177–182
  19. Yen HJ, Hsu SH, Tsai CL. Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. Small. 2009;5:1553–1561
  20. Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci. 2005;88:412–419
  21. Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol in Vitro. 2005;19:975–983
  22. Niño-Martínez N, Martínez-Castañón GA, Aragón-Piña A, Martínez-Gutierrez F, Martínez-Mendoza JR, Ruiz F. Characterization of silver nanoparticles synthesized on titanium dioxide fine particles. Nanotechnology. 2008;065711:19
  23. Clinical and Laboratory Standards Institute . Reference method for broth dilution antifungal susceptibility testing of yeasts; third informational supplement. In: Approved standard M27-A. Wayne (Penn): CLSI; 1997;
  24. Clinical and Laboratory Standards Institute . Susceptibility testing of mycobacteria, nocardia, and other aerobic actinomycetes. Wayne (Penn): CLSI; 2003;
  25. Pick N, Cameron S, Arad D, Av-Gay Y. Screening of compounds toxicity against human monocytic cell line-THP-1 by flow cytometry. Biol Proced Online. 2004;6:220–225
  26. Casarett L, Klaassen CD, Doull J. In:  Klaassen CD editors. Casarett and Doull's toxicology: the basic science of poisons. New York: McGraw-Hill; 2001;p. 23–24
  27. Olive PL, Banath JP, Durand RE. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. Radiat Res. 1990;122:86–94
  28. Lok CN, Ho CM, Chen R, He QY, Yu WY, Sun H, et al. Silver nanoparticles: partial oxidation and antibacterial activities. J Biol Inorg Chem. 2007;12:527–534
  29. Morones JR, Elechiguerra JL, Camacho A, Ramirez JT. The bactericidal effect of silver nanoparticles. Nanotechnology. 2005;16:2346–2353
  30. Martínez-Castañón GA, Niño-Martínez N, Martínez-Gutierrez F, Martínez-Mendoza JR, Ruiz F. Synthesis and antibacterial activity of silver nanoparticles with different sizes. J Nanoparticle Res. 2008;10:1343–1348
  31. Panacek A, Kvitek L, Prucek R, Kolar M, Vecerova R, Pizurova N, et al. Silver colloid nanoparticles: synthesis, characterization, and their antibacterial activity. J Phys Chem. 2006;110:16248–16253
  32. Thiel J, Pakstis L, Buzby S, Raffi M, Ni C, Pochan DJ, et al. Antibacterial properties of silver-doped titania. Small. 2007;3:799–803
  33. Zhang H, Chen G. Potent antibacterial activities of Ag/TiO2 nanocomposite powders synthesized by a one-pot sol-gel method. Environ Sci Technol. 2009;43:2905–2910

 Funding for this studies at Y.A.’s laboratory was provided by the TB Veterans Charitable Foundation and Enox Biopharma Inc. Comet experiments were supported by the Canadian Cancer Society (P.L.O.).

PII: S1549-9634(10)00095-X

doi: 10.1016/j.nano.2010.02.001

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 5 , Pages 681-688 , October 2010