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Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 5
, Pages 605-611
, October 2010
Caspase-9-dependent decrease of nuclear pore channel hydrophobicity is accompanied by nuclear envelope leakiness
References
- . The nuclear barrier is structurally and functionally highly responsive to glucocorticoids. BioEssays. 2006;28:935–942
- . The nuclear pore complex: nucleocytoplasmic transport and beyond. Nat Rev Mol Cell Biol. 2003;4:757–766
- . Dynamic nuclear pore complexes: life on the edge. Cell. 2006;125:1041–1053
- Nuclear pore complex structure and dynamics revealed by cryoelectron tomography. Science. 2004;306:1387–1390
- . Structure, dynamics and function of nuclear pore complexes. Trends Cell Biol. 2008;18:456–466
- . Yeast nuclear pore complexes have a cytoplasmic ring and internal filaments. J Struct Biol. 2004;145:272–288
- . Toward a molecular understanding of the structure and function of the nuclear pore complex. Int Rev Cytol. 1995;162B:225–255
- . Cell biology. Nuclear pore complex models gel. Science. 2006;314:766–767
- Lim RY, Fahrenkrog B, Koser J, Schwarz-Herion K, Deng J, Aebi U. Nanomechanical basis of selective gating by the nuclear pore complex. Science 2007;318:640-3.
- . Transport into and out of the nucleus. Microbiol Mol Biol Rev. 2001;65:570–594
- . Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex. Cell. 2007;129:83–96
- . Virtual gating and nuclear transport: the hole picture. Trends Cell Biol. 2003;13:622–628
- . The nuclear pore complex: oily spaghetti or gummy bear?. Cell. 2007;130:405–407
- The molecular architecture of the nuclear pore complex. Nature. 2007;450:695–701
- . Proteomic analysis of the mammalian nuclear pore complex. J Cell Biol. 2002;158:915–927
- . Peering through the pore: nuclear pore complex structure, assembly, and function. Dev Cell. 2003;4:775–789
- . Nuclear envelope permeability. Nature. 1975;254:109–114
- . FG/FxFG as well as GLFG repeats form a selective permeability barrier with self-healing properties. EMBO J. 2009;28:2554–2567
- . Characterisation of the passive permeability barrier of nuclear pore complexes. EMBO J. 2009;28:2541–2553
- . The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion. EMBO J. 2002;21:2664–2671
- Flexible phenylalanine-glycine nucleoporins as entropic barriers to nucleocytoplasmic transport. Proc Natl Acad Sci U S A. 2006;103:9512–9517
- . Cargo surface hydrophobicity is sufficient to overcome the nuclear pore complex selectivity barrier. EMBO J. 2009;28:2697–2705
- . Caspases disrupt the nuclear-cytoplasmic barrier. J Cell Biol. 2000;151:951–959
- . Caspases mediate nucleoporin cleavage, but not early redistribution of nuclear transport factors and modulation of nuclear permeability in apoptosis. Cell Death Differ. 2001;8:495–505
- . Nucleocytoplasmic transport in apoptosis. Cell Death Differ. 2005;12:1263–1276
- . Apoptosis leads to a degradation of vital components of active nuclear transport and a dissociation of the nuclear lamina. Proc Natl Acad Sci U S A. 2008;105:11236–11241
- . Resting membrane potential as a marker of apoptosis: studies on Xenopus oocytes microinjected with cytochrome c. Cell Death Differ. 2001;8:63–69
- . Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. EMBO J. 1997;16:1153–1163
- . Atomic force microscopy visualises a hydrophobic meshwork in the central channel of the nuclear pore. Pflugers Arch. 2008;456:155–162
- The genome of HSV-1 translocates through the nuclear pore as a condensed rod-like structure. J Cell Sci. 2006;119:23–30
- . Investigation of nuclear envelope structure and passive permeability. Methods Mol Biol. 2009;464:161–180
- Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997;91:479–489
- . Study of apoptosis in vitro using the Xenopus egg extract reconstitution system. Methods Mol Biol. 2006;322:379–393
- . The Drosophila RCC1 homolog, Bj1, regulates nucleocytoplasmic transport and neural differentiation during Drosophila development. Dev Biol. 2004;270:106–121
- . Essential role of active nuclear transport in apoptosis. Genes Cells. 1997;2:55–64
- . Multiple mechanisms promote the inhibition of classical nuclear import upon exposure to severe oxidative stress. Cell Death Differ. 2004;11:862–874
- . Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). J Biol Chem. 2005;280:857–860
- . Correlation between nucleocytoplasmic transport and caspase-3-dependent dismantling of nuclear pores during apoptosis. Exp Cell Res. 2004;293:346–356
- . Increased nuclear envelope permeability and Pep4p-dependent degradation of nucleoporins during hydrogen peroxide-induced cell death. FEMS Yeast Res. 2005;5:1237–1251
- . Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis. J Cell Sci. 2000;113:2941–2953
- . Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis. J Cell Sci. 1999;112:1743–1753
- . Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis. J Cell Biol. 1993;123:7–22
- . Cell death: the significance of apoptosis. Int Rev Cytol. 1980;68:251–306
- . Atomic force microscope. Phys Rev Lett. 1986;56:930–933
- Potassium softens vascular endothelium and increases nitric oxide release. Proc Natl Acad Sci U S A. 2009;106:2829–2834
- . Individual binding pockets of importin-beta for FG-nucleoporins have different binding properties and different sensitivities to RanGTP. Proc Natl Acad Sci U S A. 2008;105:16101–16106
- Aldosterone signaling pathway across the nuclear envelope. Proc Natl Acad Sci U S A. 2002;99:7154–7159
This study was supported by grants from the Innovative Medizinische Forschung (no. SH-110315, SH-520404, and SH-120613) and the Deutsche Forschungsgemeinschaft (Graduate School Molecular Basis of Dynamic Cellular Processes) of the SFB629, International Graduate School, Interaction of pathogens with biotic and abiotic surfaces GRK1409 and OB 63/16-1, and Interdisciplinary Center of Clinical Research (IZKF) Münster, project no. Küh3/064/04.
PII: S1549-9634(10)00154-1
doi: 10.1016/j.nano.2010.04.006
© 2010 Elsevier Inc. All rights reserved.
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Nanomedicine: Nanotechnology, Biology and Medicine
Volume 6, Issue 5
, Pages 605-611
, October 2010
