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Volume 8, Issue 2 , Pages 136-146 , February 2012

Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells

Huan Meng, PhD
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
- These authors contributed equally to this work.
Gengmei Xing, PhD
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
- These authors contributed equally to this work.
Elvin Blanco, PhD
- Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, Texas, USA
Yan Song, BS
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
Lina Zhao, PhD
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
Baoyun Sun, PhD
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
Xiaoda Li, MS
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
Paul C. Wang, PhD
- Laboratory of Molecular Imaging, Department of Radiology, Howard University, Washington, DC, USA
Alexandru Korotcov, PhD
- Laboratory of Molecular Imaging, Department of Radiology, Howard University, Washington, DC, USA
Wei Li, PhD
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
Xing-Jie Liang, PhD
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
Chunying Chen, PhD
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
Hui Yuan, MS
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
Feng Zhao, MS
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
Zhen Chen, PhD
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
Tong Sun, MS
- Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, Texas, USA
Zhifang Chai, PhD
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
Mauro Ferrari, PhD
- Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, Texas, USA
Yuliang Zhao, PhD
- CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, and National Center for Nanosciences and Technology of China, Beijing China
- Research Center for Cancer Nanotechnology, Tianjin Cancer Hospital and Chinese Academy of Sciences, Tianjin, China
- Corresponding author: CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, and National Center for Nanosciences and Technology of China, Beijing, China.

Received 10 May 2011 ,Accepted 28 August 2011.

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The authors thank for the support of MOST 973 program (2009CB930204, 2011CB933403, 2010CB934000, 2012CB934000) and CAS Knowledge Innovation Program. This study was partly funded by National Natural Science Foundation of China (10875136), and U.S NIH/RCMI/NCRR (2G12RR003048) and DOD (W81XWH-10-1-0767). M.F., T.S., E.B., are grateful for the support of the U.S. DoD Innovator Award (W81XWH-09-1-0212), NIH U54CA143837 and U54CA151668, and the Ernest Cockrell Jr. Distinguished Endowed Chair.

PII: S1549-9634(11)00356-X

doi: 10.1016/j.nano.2011.08.019

« Previous Next » Nanomedicine: Nanotechnology, Biology and Medicine
Volume 8, Issue 2 , Pages 136-146 , February 2012