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Improved antibacterial and antibiofilm activity of magnesium fluoride nanoparticles obtained by water-based ultrasound chemistry

  • Jonathan Lellouche, MSc

      Affiliations

    • The Biofilm Research Laboratory, The Bar-Ilan Institute of Nanotechnology and Advanced Materials, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
    • Department of Chemistry, The Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel
    • ,
  • Alexandra Friedman, MSc

      Affiliations

    • Department of Chemistry, The Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel
    • ,
  • Jean-Paul Lellouche, PhD

      Affiliations

    • Department of Chemistry, The Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel
    • ,
  • Aharon Gedanken, PhD

      Affiliations

    • Department of Chemistry, The Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel
    • ,
  • Ehud Banin, PhD

      Affiliations

    • The Biofilm Research Laboratory, The Bar-Ilan Institute of Nanotechnology and Advanced Materials, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
    • Corresponding Author InformationCorresponding author:

Received 9 November 2010; accepted 6 September 2011. published online 22 September 2011.
Corrected Proof

Abstract 

Antibiotic resistance has prompted the search for new agents that can inhibit bacterial growth. We recently reported on the antimicrobial and antibiofilm activities of nanosized magnesium fluoride (MgF2) nanoparticles (NPs) synthesized in ionic liquid using microwave chemistry. In this article, we describe a novel water-based synthesis of MgF2 NPs using sonochemistry. The sonochemical irradiation of an aqueous solution of [Mg(OAc)2⋅(H2O)4] containing acidic HF as the fluorine ion source afforded crystalline well-shaped spherical MgF2 NPs that showed much improved antibacterial properties against two common bacterial pathogens (Escherichia coli and Staphylococcus aureus). We were also able to demonstrate that the antimicrobial activity was dependent on the size of the NPs. In addition, using the described sonochemical process, we coated glass surfaces and demonstrated inhibition of bacterial colonization for 7 days. Finally, the antimicrobial activity of MgF2 NPs against established biofilms was also examined. Taken together our results highlight the potential to further develop the concept of utilizing these metal fluoride NPs as novel antimicrobial and antibiofilm agents.

Graphical Abstract 

Antibiofilm activity of MgF2 NP coatings

Antibiofilm activity of MgF2 NP coatings. CLSM images of E. coli and S. aureus biofilm formation after 7 days on uncoated and MgF2 NP-coated glass surfaces. Green and red staining represents live and dead bacterial cells, respectively.

Key words: Magnesium fluoride nanoparticles, Sonochemistry, Antibacterial properties, Biofilms, Aggregation

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 The authors confirm that there are no known conflicts of interest associated with this publication, and there has been no significant financial support for this work that could have influenced its outcome (current and the past five years).

PII: S1549-9634(11)00359-5

doi:10.1016/j.nano.2011.09.002

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