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Diagnostic applications of Raman spectroscopy

  • Qiang Tu, MS

      Affiliations

    • School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA
    • ,
  • Chang Chang, PhD

      Affiliations

    • School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA
    • Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    • Corresponding Author InformationCorresponding author: Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Received 31 March 2011; accepted 24 September 2011. published online 24 October 2011.
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Abstract 

Raman spectroscopy has been widely used in various fields of science. It has been successfully utilized to qualitatively and quantitatively determine the molecular compositions of solid, liquid, and gaseous samples. This review focuses on the diagnostic applications of Raman spectroscopy in the past 5 years, with specific emphasis on transplant allograft rejection and cancer detections. First we introduce the principle of Raman spectroscopy and associated surface enhancement techniques. Various recent biomedical and clinical applications of Raman spectroscopy are then reviewed in detail. Finally, we present the experimental and analytical techniques required to implement Raman spectroscopy in a laboratory.

Graphical Abstract 

Raman spectroscopy is a powerful tool that has been widely used in both biological and medical sciences. This review presents the fundamental principles, experimental apparatus, analysis methods, and diagnostic applications of Raman spectroscopy. Various surface enhancement techniques that further improve the sensitivity of Raman spectroscopy are also introduced. The figure illustrates the use of Raman spectroscopy for cardiac transplant rejection surveillance.

Key words: Raman spectroscopy, SERS, Cancer diagnosis, Transplant rejection

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 Sources of support: Wallace H. Coulter Foundation Translational Research Grant.

PII: S1549-9634(11)00370-4

doi:10.1016/j.nano.2011.09.013

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