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Lapatinib/Paclitaxel polyelectrolyte nanocapsules for overcoming multidrug resistance in ovarian cancer

  • Daniele Vergara, PhD

      Affiliations

    • Laboratory of General Physiology, Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy
    • Laboratory of Clinical Proteomic, “Giovanni Paolo II” Hospital, Lecce, Italy
  • ,
  • Claudia Bellomo, MS

      Affiliations

    • NNL–Istituto Nanoscienze, Italy
  • ,
  • Xingcai Zhang, MS

      Affiliations

    • Institute for Micromanufacturing, Louisiana Tech University, Ruston, Louisiana, USA
  • ,
  • Viviana Vergaro, MS

      Affiliations

    • NNL–Istituto Nanoscienze, Italy
  • ,
  • Andrea Tinelli, MD

      Affiliations

    • Department of Obstetrics and Gynaecology, Vito Fazzi Hospital, Lecce, Italy
  • ,
  • Vito Lorusso, MD

      Affiliations

    • Department of Medical Oncology, Vito Fazzi Hospital, Lecce, Italy
  • ,
  • Ross Rinaldi, PhD

      Affiliations

    • NNL-Istituto Nanoscienze, CNR University of Salento, Department of Innovation Engineering, Lecce, Italy
  • ,
  • Yuri M. Lvov, PhD

      Affiliations

    • Institute for Micromanufacturing, Louisiana Tech University, Ruston, Louisiana, USA
  • ,
  • Stefano Leporatti, PhD

      Affiliations

    • NNL–Istituto Nanoscienze, Italy
    • Corresponding Author InformationCorresponding author. NNL, Istituto Nanoscienze, CNR Via Arnesano 16Lecce 73100, Italy.
  • ,
  • Michele Maffia, PhD

      Affiliations

    • Laboratory of General Physiology, Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy
    • Laboratory of Clinical Proteomic, “Giovanni Paolo II” Hospital, Lecce, Italy

Received 20 May 2011 ,Accepted 30 October 2011. Published online 17 November 2011 Corrected Proof

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 No conflict of interest was reported by the authors of this article.

 This work was funded by the Italian Ministry of University and Research (MIUR) through the FIRB project no. RBLA03ER38, “Con il contributo del Ministero degli Affari Esteri (MAE), Direzione Generale per la promozione e la Cooperazione Sociale ” (Italy –USA Large Scale Bilateral Project “Nano-trasportatori per la terapia del cancro”). This work was also supported by the PS105 ARTI strategic project “Development and realization of bio-chip for molecular diagnostic and categorization of human pathogenic viruses (HPV, HCV)” of Apulia Region and by a contribution of “ANGELA SERRA” Foundation For Cancer Research, Parabita (Lecce, Italy). No support came from any commercial association.

PII: S1549-9634(11)00522-3

doi: 10.1016/j.nano.2011.10.014

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