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Bioactive silica-based nanoparticles stimulate bone-forming osteoblasts, suppress bone-resorbing osteoclasts, and enhance bone mineral density in vivo

  • George R. Beck Jr., PhD

      Affiliations

    • The Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, Georgia, USA
    • The Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    • Corresponding Author InformationCorresponding author: 101 Woodruff Circle, 1305 WMRB, Atlanta, Georgia 30322-0001.
    • These authors contributed equally to this work.
    • ,
  • Shin-Woo Ha, PhD

      Affiliations

    • The Department of Chemistry, Seoul National University, Seoul, Korea
    • These authors contributed equally to this work.
    • ,
  • Corinne E. Camalier, MS

      Affiliations

    • The Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, Georgia, USA
    • ,
  • Masayoshi Yamaguchi, PhD

      Affiliations

    • The Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, Georgia, USA
    • ,
  • Yan Li, MD

      Affiliations

    • The Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, Georgia, USA
    • ,
  • Jin-Kyu Lee, PhD

      Affiliations

    • The Department of Chemistry, Seoul National University, Seoul, Korea
    • ,
  • M. Neale Weitzmann, PhD

      Affiliations

    • The Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, Georgia, USA
    • The Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    • The Atlanta Department of Veterans Affairs Medical Center, Decatur, Georgia 30033, USA
    • Corresponding Author InformationCorresponding author: 101 Woodruff Circle, 1305 WMRB, Atlanta, Georgia 30322-0001.
    • These authors contributed equally to this work.

Received 8 March 2011 ,Accepted 3 November 2011. Published online 17 November 2011 Corrected Proof

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 This study was supported by a grant from NIAMS (AR056090) and by a Georgia Research Alliance grant (GRA.VL12.C2) to M.N. Weitzmann and G.R. Beck. M.N. Weitzmann is also supported in part by funding from the Biomedical Laboratory Research & Development Service of the VA Office of Research and Development (5I01BX000105) and by grants AR059364 and AR053607 from NIAMS and AG040013 from NIA. G.R. Beck is also supported in part by NCI grants (CA136059 and CA136716). J-K. Lee expresses his thanks for a fellowship from the SBS Foundation in Korea to initiate this research collaboration.

PII: S1549-9634(11)00523-5

doi: 10.1016/j.nano.2011.11.003

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