Nanomedicine: Nanotechnology, Biology and Medicine
Volume 8, Issue 4 , Pages 415-418 , May 2012

Initial studies of mechanical compression on neurogenesis with neonatal neural stem cells

  • Leyla Esfandiari, MS

      Affiliations

    • Biomedical Engineering Interdepartmental Program, University of California, Los Angeles, California, USA
    • ,
  • Michelle Paff, MS

      Affiliations

    • Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA
    • ,
  • William C. Tang, PhD

      Affiliations

    • Department of Biomedical Engineering, University of California, Irvine, California, USA
    • Department of Electrical Engineering and Computer Science, University of California, Irvine, California, USA
    • Corresponding Author InformationCorresponding author: Henry Samueli School of Engineering, 5200 Engineering Hall, University of California, Irvine, California 92697-2700, USA.

Received 16 July 2011 ,Accepted 11 January 2012.

References 

  1. Valenzuela M, Sidhu K, Sachdev D. Neural stem cell therapy for neuropsychiatric disorders. Acta Neuropsychiatr. 2007;19:11–26
  2. Avino TA, Hutsler JJ. Abnormal cell patterning at the cortical gray-white matter boundary in autism spectrum disorders. Brain Res. 2010;1360:138–146
  3. Van Essen DC. A tension-based theory of morphogenesis and compact wiring in the central nervous system. Nature. 1997;385:313–318
  4. Teixeira AI, Ilkhanizadeh S, Wigenius JA, Duckworth JK, Inganäs O, Hermanson O. The promotion of neuronal maturation on soft substrates. Biomaterials. 2009;30:4567–4572
  5. Miyata T, Ogawa M. Twisting of neocortical progenitor cells underlies a spring-like mechanism for daughter-cell migration. Curr Biol. 2007;17:146–151
  6. Duffy DC, McDonald JC, Schueller OJA, Whitesides GM. Rapid prototyping of microfluidic systems in poly(dimethylsiloxane). Anal Chem. 1998;70:4974–4984
  7. Gregg C, Weiss S. Generation of functional radial glial cells by embryonic and adult forebrain neural stem cells. J Neurosci. 2003;23:11587–11601
  8. Ahmed S. The culture of neural stem cells. J Cell Biochem. 2009;106:1–6
  9. Lin G, Wu VI, Hainley RE, Flanagan LA, Monuki ES, Tang WC. Development of a MEMS microsystem to study the effect of mechanical tension on cerebral cortex neurogenesis. Conf Proc IEEE Eng Med Biol Soc. 2004;4:2607–2610

 The topic of this invited contribution has been presented at the 4th IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE-NANOMED 2010), December 5-9, 2010, Hong Kong SAR, China.

 Source of support: University of California, Irvine, Multi-Investigator Faculty Research Grant.

PII: S1549-9634(12)00008-1

doi: 10.1016/j.nano.2012.01.001

Nanomedicine: Nanotechnology, Biology and Medicine
Volume 8, Issue 4 , Pages 415-418 , May 2012

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