PerspectiveCaging cancer
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Cited by (14)
Therapeutic targets in the selective killing of cancer cells by nanomaterials
2017, Clinica Chimica ActaCitation Excerpt :NMs composed of cobalt oxide, on the other hand, induced greater toxicity in BEAS-2B cells that originated from normal tissue, but the toxicity was negligible in A549 cells that originated from cancerous tissue [161]. A deeper understanding of the exact relations between the physicochemical characteristics of the NMs and the biologic events may lead to a new class of effective anticancer pharmaceutics [162]. A better understanding of the biochemical features of cancer and our ability to predict NM-induced bio-responses would facilitate the engineering of NMs with desired bio-physicochemical properties that might be more efficient in achieving selectivity in the killing of cancer cells while not affecting normal cells.
Fullerenols: Physicochemical properties and applications
2016, Progress in Solid State ChemistryCitation Excerpt :However, further research on toxicity, biodistribution, and biodegradation of fullerenols is needed. In order to obtain mоre detailed information on biomedical applications of fullerenol and other water-soluble fullerene derivatives, the interested reader is referred to several in-depth studies [85,86,111–113]. The possible applications of fullerenols in bionanomedicine are summarized in Fig. 16.
Biological interactions of carbon-based nanomaterials: From coronation to degradation
2016, Nanomedicine: Nanotechnology, Biology, and MedicineCitation Excerpt :In particular, gadolinium (Gd) based metallofullerenes are developed as innovative contrast agents, and may also act as anti-cancer agents.46 For example, the multi-hydroxylated metallofullerenol Gd@C82(OH)22 was recently shown to inhibit tumor metastasis through MMP inhibition rather than through direct killing of the cancer cells,47 thus suggesting a new, nanomedicine-based approach in the management of tumor metastasis.48 In subsequent studies, based on computational and experimental approaches, the authors proposed that Gd@C82(OH)22 suppress pancreatic cancer metastasis by inhibiting the interaction of histone deacetylase 1 (HDAC1) and metastasis-associated protein 1 (MTA1), thus acting as a novel HDAC inhibitor.49
Effects of Endohedral Gd-Containing Fullerenols with a Different Number of Oxygen Substituents on Bacterial Bioluminescence
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